ChemInform Abstract: Natural Organic Compounds that Affect to Microtubule Functions: Syntheses and Structure-Activity Relationships of Combretastatins, Curacin A and Their Analogues as the Colchicine-Site Ligands on Tubulin

ChemInform ◽  
2001 ◽  
Vol 32 (6) ◽  
pp. no-no
Author(s):  
Shigeo Iwasaki ◽  
Ryuichi Shirai
Keyword(s):  
Organic Compounds ◽  
Structure Activity Relationships ◽  
Curacin A ◽  
Structure Activity ◽  
Natural Organic Compounds

scholarly journals Diversified Carbohydrate-Binding Lectins from Marine Resources

2011 ◽  
Vol 2011 ◽  
pp. 1-20 ◽  
Author(s):  
Tomohisa Ogawa ◽  
Mizuki Watanabe ◽  
Takako Naganuma ◽  
Koji Muramoto
Keyword(s):  
Fatty Acids ◽  
Molecular Evolution ◽  
Organic Compounds ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Marine Resources ◽  
Carbohydrate Binding ◽  
Structure Activity ◽  
Natural Organic Compounds ◽  
Binding Lectin

Marine bioresources produce a great variety of specific and potent bioactive molecules including natural organic compounds such as fatty acids, polysaccharides, polyether, peptides, proteins, and enzymes. Lectins are also one of the promising candidates for useful therapeutic agents because they can recognize the specific carbohydrate structures such as proteoglycans, glycoproteins, and glycolipids, resulting in the regulation of various cells via glycoconjugates and their physiological and pathological phenomenon through the host-pathogen interactions and cell-cell communications. Here, we review the multiple lectins from marine resources including fishes and sea invertebrate in terms of their structure-activity relationships and molecular evolution. Especially, we focus on the unique structural properties and molecular evolution of C-type lectins, galectin, F-type lectin, and rhamnose-binding lectin families.

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