scholarly journals Multicellular mechanochemical hybrid cellular Potts model of tissue formation during epithelial‐mesenchymal transition

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Shreyas U. Hirway ◽  
Christopher A. Lemmon ◽  
Seth H. Weinberg
Keyword(s):  
Potts Model ◽  
Epithelial Mesenchymal Transition ◽  
Tissue Formation ◽  
Cellular Potts Model ◽  
Mesenchymal Transition

scholarly journals A Multiscale computational model of YAP signaling in epithelial fingering behaviour

2021 ◽  
Author(s):  
Naba Mukhtar ◽  
Leah Edelstein-Keshet ◽  
Eric N Cytrynbaum
Keyword(s):  
Wound Healing ◽  
Intracellular Signaling ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Model Simulation ◽  
Multiscale Model ◽  
Cellular Potts Model ◽  
Mesenchymal Transition ◽  
E Cadherin

In epithelial-mesenchymal transition (EMT), cells organized into sheets break away and become motile mesenchymal cells. EMT plays a crucial role in wound healing, embryonic development, and cancer metastasis. Intracellular signaling in response to mechanical, topographic, or chemical stimuli can promote EMT. We present a multiscale model for EMT downstream of the protein YAP, which suppresses the cell-cell adhesion protein E-cadherin and activates the GTPase Rac1 that enhances cell migration. We first propose an ODE model for YAP/Rac1/E-cadherin interactions. The model dynamics are bistable, accounting for motile loose cells as for adherent slower cells. We implement this model in a cellular Potts model simulation of 2D wound-healing using the open source platform Morpheus. We show that, under suitable stimuli (depicting topographic cues) the sheet exhibits finger-like projections and EMT. Morphological, as well as quantitative differences in YAP levels as well as cell speed across the sheet are consistent with preexisting experimental observations of epithelial sheets grown on topographic features in vitro. The simulation is also consistent with experiments that knockdown or over-express YAP, inhibit Rac1, or block E-cadherin.

Epithelial-Mesenchymal Transition Delayed by E-cad to Promote Tissue Formation in Hepatic Differentiation of Mouse Embryonic Stem Cells In Vitro

2014 ◽  
Vol 23 (8) ◽  
pp. 877-887 ◽  
Author(s):  
Anbin Hu ◽  
Changzhen Shang ◽  
Qiang Li ◽  
Nianfeng Sun ◽  
Linwei Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Epithelial Mesenchymal Transition ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Tissue Formation ◽  
Hepatic Differentiation ◽  
Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) in vulvar cancer with and without inguinal lymph node metastases

2014 ◽  
Vol 74 (05) ◽  
Author(s):  
C Eckey ◽  
AK Höhn ◽  
M Höckel ◽  
R Scherling ◽  
B Hentschel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Vulvar Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Inguinal Lymph Node ◽  
Mesenchymal Transition ◽  
Node Metastases

Epithelial-mesenchymal transition of biliary epithelial cells during cholestatic fibrosis

2007 ◽  
Vol 45 (01) ◽  
Author(s):  
F Schulze ◽  
E Konze ◽  
K Petmecky ◽  
K Schardt ◽  
O Dirsch ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Biliary Epithelial Cells

Sparsely granulated somatotroph adenomas display aspects of epithelial-mesenchymal transition

2016 ◽  
Author(s):  
Kathryn Dix ◽  
Ashley Grossman ◽  
Olaf Ansorge ◽  
Sarah Larkin
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

2019 ◽  
Author(s):  
Andrew Redfern ◽  
Veenoo Agarwal ◽  
Lisa Spalding ◽  
Tony Blick ◽  
Alexander Dobrovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition
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