scholarly journals Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor‐infiltrating cells

2020 ◽  
Vol 9 (10) ◽  
Author(s):  
Yasuyoshi Sato ◽  
Ikuo Wada ◽  
Kosuke Odaira ◽  
Akihiro Hosoi ◽  
Yukari Kobayashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Functional Status ◽  
Infiltrating Cells ◽  
Immunological Classification

Associations between skeletal muscle mass index, nutritional and functional status of patients with oesophago-gastric cancer

2019 ◽  
Vol 34 ◽  
pp. 61-67 ◽  
Author(s):  
Irene Lidoriki ◽  
Dimitrios Schizas ◽  
Eustratia Mpaili ◽  
Michail Vailas ◽  
Maria Sotiropoulou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Skeletal Muscle ◽  
Functional Status ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Skeletal Muscle Mass Index

Gastric cancer: nutritional and functional status & survival time/mortality

2021 ◽  
Vol 46 ◽  
pp. S720-S721
Author(s):  
C.A. Santos ◽  
I.M. Santos ◽  
L. Mendes ◽  
H. Mansinho
Keyword(s):  
Gastric Cancer ◽  
Functional Status ◽  
Survival Time

Reply to comment on “Are body mass index and performance status enough to assess the nutritional and functional status of elderly patients undergoing gastric cancer surgery?”

Surgery Today ◽  
2018 ◽  
Vol 48 (12) ◽  
pp. 1102-1103 ◽  
Author(s):  
Makoto Hikage ◽  
Masanori Tokunaga ◽  
Rie Makuuchi ◽  
Tomoyuki Irino ◽  
Yutaka Tanizawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Elderly Patients ◽  
Functional Status ◽  
Body Mass ◽  
Performance Status ◽  
Cancer Surgery ◽  
Gastric Cancer Surgery ◽  
And Performance

Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer

2020 ◽  
Vol 69 (7) ◽  
pp. 1327-1336 ◽  
Author(s):  
Ruochen Li ◽  
Heng Zhang ◽  
Yifan Cao ◽  
Xin Liu ◽  
Yifan Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Functional Status ◽  
Cd8 T Cells ◽  
Prognostic Value ◽  
Lauren Classification ◽  
Laurén Classification

scholarly journals Prognostic values of signal transducers activators of transcription in gastric cancer

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Yujie Zhang ◽  
Chaoran Yu
Keyword(s):  
Gastric Cancer ◽  
Cd8 T Cells ◽  
Prognostic Markers ◽  
Risk Group ◽  
Her2 Status ◽  
Signal Transducers ◽  
Kaplan Meier ◽  
Infiltrating Cells ◽  
Kaplan Meier Plotter

AbstractThe signal transducers and activators of transcription genes family (STATs) have been well studied as prognostic predictors for various solid tumors, but their prognostic values in gastric cancer (GC) patients have not been fully elucidated. The ‘Kaplan–Meier plotter’ and multiple public available databases were used for the characterization of the prognostic roles of STATs family in GC. The results indicated that high mRNA expression of all individual STATs, except STAT3 and STAT6, were significantly associated with favorable overall survival (OS) in GC. Moreover, the prognostic values of STATs were further characterized in subtypes, including HER2 status, Lauren’s classification, differentiation, and clinical stages. Moreover, the prognostic value of STATs signature was also characterized. Low risk group displayed a significantly favorable OS than high risk (HR: 1.71; 95% CI: 1.09–2.66, P=0.0184). In addition, STATs showed distinct expression between GC and normal groups. Meanwhile, comparable high correlation between STATs and tumor immune infiltrating cells (TIICs) was also observed. STAT4 displayed highest correlation with dendritic cells (correlation = 0.716, P=1.63e-59) and CD8+ T cells (correlation = 0.697, P=5.02e-55). In conclusion, our results suggest that all individual STATs, except STAT3 and STAT6, may act as prognostic markers in GC.

scholarly journals Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tenghui Han ◽  
Dong Xu ◽  
Jun Zhu ◽  
Jipeng Li ◽  
Lei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Group ◽  
Noncoding Rnas ◽  
High Risk Group ◽  
Long Noncoding Rnas ◽  
Immune Checkpoints ◽  
Clinical Samples ◽  
Clinical Factor ◽  
Infiltrating Cells

Abstract Background Gastric cancer (GC) is a globally prevalent cancer, ranking fifth for incidence and fourth for mortality worldwide. The N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) were widely investigated in recent studies. Nevertheless, the underlying prognostic implication and tumor immune mechanism of m6A-related lncRNA in GC remain unknown. Methods We systematically assessed the m6A modification expression of 407 GC clinical samples based on 23 m6A regulators and comprehensively associated these genes with lncRNAs. Then, we constructed a m6A-related lncRNA prognostic signature (m6A-LPS) to evaluate both status and prognosis of the disease. Immune-related mechanisms were explored via dissecting tumor-infiltrating cells as well as applying tumor immune dysfunction and the exclusion algorithm. Furthermore, we validated the latent regulative mechanism of m6A-related lncRNA in GC cell lines. Results The m6A-LPS containing nine hub lncRNAs was built, which possessed a superior capability to predict the outcomes of GC patients. Meanwhile, we found an intimate correlation between the m6A-LPS and tumor infiltrating cells, and that the low-risk group had a higher expression of immune checkpoints and responsed more to immunotherapy than the high-risk group. Clinically, these crucial lncRNAs expression levels were verified in ten pairs of GC samples. In in vitro experiments, the abilities of migration and proliferation were significantly enhanced via downregulating the lncRNA AC026691.1. Both migrative and proliferative capabilities of tumor cells were significantly enhanced via downregulating the lncRNA AC026691.1. in vitro. Conclusions Collectively, the m6A-LPS could provide a novel prediction insight into the prognosis of GC patients and serve as an independent clinical factor for GC. These m6A-related lncRNAs might remodel the tumor microenvironment and affect the anti-cancer ability of immune checkpoint blockers. Importantly, lncRNA AC026691.1 could inhibit both migration and proliferation of GC by means of FTO regulation.

scholarly journals Factors affecting the quality of life of gastric cancer survivors

2022 ◽  
Author(s):  
Jahyun Choi ◽  
Sanghee Kim ◽  
Mona Choi ◽  
Woo Jin Hyung
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Social Support ◽  
Cancer Survivors ◽  
Functional Status ◽  
Self Efficacy ◽  
Well Being ◽  
Factors Affecting ◽  
Specific Symptoms

Abstract Background The number of gastric cancer survivors has been increasing, and such survivors experience various changes in their lives post-recovery. Adapting to these changes requires appropriate interventions that can improve their quality of life (QoL). This study was conducted to investigate the factors affecting the QoL of gastric cancer survivors and provide basic data for effective intervention. Methods Data were collected between September 8 and September 29, 2017, from the Gastric Cancer Center at a tertiary hospital. Questionnaire surveys were conducted using the EORTC QLQ-C30/STO22, Self-Efficacy-Scale, Multidimensional Scale of Perceived Social Support, and Quality of Life-Cancer Survivors Questionnaire on gastric cancer survivors who were followed up for 3 years after gastrectomy. Data were analyzed using descriptive statistics, t test, ANOVA, Pearson’s correlation coefficient, and multiple regression analysis. Results A total of 136 gastric cancer survivors completed the questionnaire survey. There were significant positive correlations of QoL with self-efficacy, functional status, and social support (r = .35, p < .001; r = .53, p < .001; r = .26, p < .001, respectively). There were significant negative correlations of QoL with general symptoms (r =  − .39, p < .001) and gastric cancer-specific symptoms (r =  − .51, p < .001). The regression model explained 48.3% of the QoL, and the affecting factors were gastric cancer-specific symptoms (β =  − .397, p < .001), religious belief (β = .299, p < .001), functional status (β = .251, p = .003), and self-efficacy (β = .191, p = .004). Conclusion This study confirmed that gastric cancer-specific symptoms, spiritual well-being, self-efficacy, and functional status affect the QoL of gastric cancer survivors. Hence, these factors should be considered in the interventions to improve the QoL of gastric cancer survivors.

Abstract 2050: Novel immunological classification of gastric cancer by integrative analysis

2020 ◽  
Author(s):  
Yasuyoshi Sato ◽  
Ikuo Wada ◽  
Akihiro Hosoi ◽  
Yukari Kobayashi ◽  
Koji Nagaoka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Integrative Analysis ◽  
Immunological Classification
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