Vitamin D insufficiency is associated with metabolic syndrome independent of insulin resistance and obesity in young, but not in old adults – Results from The Berlin Aging Study II

AbstractObjectiveThe present study aimed to evaluate the frequency of deficiency/insufficiency of vitamin D in adolescents and its relationship to overweight and metabolic disorders.DesignCross-sectional study. Nutritional status was assessed by BMI according to WHO recommendations. Dietary intake was evaluated using a 3 d dietary record. The biochemical evaluation comprised measurements of serum lipids, lipoproteins, glucose, insulin, calcidiol (25(OH)D) and parathyroid hormone. Insulin resistance was calculated using the homeostasis model assessment. Body composition and blood pressure were assessed.SettingFifteen schools (eight public and seven private) in the central city of Juiz de Fora, Brazil.SubjectsThe analysis included a study population of 160 adolescents (seventy-seven eutrophic and eighty-three overweight) aged 15 to 17 years.ResultsVitamin D deficiency and insufficiency was observed in 1·25 and 70·6 % of adolescents, respectively. Serum 25(OH)D levels were statistically lower in adolescents with weight excess, abdominal obesity, hypercholesterolaemia, higher levels of parathyroid hormone, insulin resistance, hyperinsulinaemia and hypertension (P < 0·05). Lower BMI and waist circumference were observed in the third (highest) tertile of vitamin D intake for all adolescents. The high prevalence of vitamin D insufficiency is primarily nutritional and reflects a low vitamin D intake.ConclusionsOur results support the negative association among serum 25(OH)D levels and vitamin D intake with non-skeletal outcomes in Brazilian adolescents. Vitamin D fortification of foods and/or the use of vitamin D supplements need to be considered to raise vitamin D intake in the adolescent population, even in a sunny country like Brazil.

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Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

Galician Medical Journal ◽

10.21802/gmj.2021.1.3 ◽

2021 ◽

Vol 28 (1) ◽

pp. E202113

Author(s):

Sevil Karahan Yılmaz ◽

Cuma Mertoğlu ◽

Aylin Ayaz

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Vitamin D Insufficiency ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

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Plasma vitamin D levels and risk of metabolic syndrome in Canadians

Clinical & Investigative Medicine ◽

10.25011/cim.v34i6.15899 ◽

2011 ◽

Vol 34 (6) ◽

pp. 377 ◽

Cited By ~ 46

Author(s):

Darren R Brenner ◽

Paul Arora ◽

Bibiana Garcia-Bailo ◽

Thomas MS Wolever ◽

Howard Morrison ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Plasma Level ◽

Linear Models ◽

Smoking Status ◽

Plasma Vitamin ◽

Model Assessment ◽

Vitamin D Levels ◽

Metabolic Syndrome Components

Purpose: Vitamin D deficiency has been implicated in susceptibility to the development of metabolic syndrome, obesity and type 2 diabetes mellitus. The present study aimed to quantify the association between vitamin D plasma level, the number of metabolic syndrome components and insulin resistance in Canadians. Methods: Vitamin D plasma level and clinical data were determined from 1,818 subjects from the Canadian Health Measures Survey; a representative health survey of the general population of Canada conducted from 2007 to 2009. The definition of metabolic syndrome was based on the National Cholesterol Education Program, Adult Treatment Panel III criteria. Adjusted general linear models were used to estimate the association between vitamin D level and probability of having metabolic syndrome, as well as the association between plasma vitamin D and insulin resistance (homeostasis model assessment for insulin resistance, or HOMA-IR). Results: The prevalence of metabolic syndrome in the study population was 8.9%. The number of metabolic syndrome components was inversely correlated with plasma vitamin D level (ρ= -0.1, p < 0.0001). Subjects in the highest vitamin D quartile had lower odds ratio of metabolic syndrome compared with their counterparts in the lowest vitamin D quartile (0.50, 95% CI= 0.24-1.06). Increasing plasma vitamin D level (by 10 nmol/L) was inversely associated with HOMA-IR score (β= -0.08, p=0.006) in a model adjusted for physical activity, smoking status, month of interview, age, sex and ethnicity. Conclusion: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.

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World endocrinology news

Obesity and metabolism ◽

10.14341/omet2008245-54 ◽

2008 ◽

Vol 5 (2) ◽

pp. 45-54

Author(s):

M A Berkovskaya

Keyword(s):

Insulin Resistance ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Vitamin D ◽

Glucose Metabolism ◽

Oral Cancer ◽

Fat Distribution ◽

Lower Prevalence ◽

The Metabolic Syndrome

The role of interleukin-6 in insulin resistance, body fat distribution and energy balance Disorders of glucose metabolism and risk of oral cancer. Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife--SWAN, the study of women's health across the nation. Vitamin D deficiency and risk of cardiovascular disease. Adypocyte prolactin: regulation of release and putative functions.

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Insulin Resistance and Vitamin D Deficiency in Patients With Chronic Kidney Disease Stage 2-3

Physiological Research ◽

10.33549/physiolres.931814 ◽

2011 ◽

pp. 149-155 ◽

Cited By ~ 13

Author(s):

K. ŠTEFÍKOVÁ ◽

V. SPUSTOVÁ ◽

Z. KRIVOŠÍKOVÁ ◽

A. OKŠA ◽

K. GAZDÍKOVÁ ◽

...

Keyword(s):

Insulin Resistance ◽

Chronic Kidney Disease ◽

Vitamin D ◽

Insulin Sensitivity ◽

Kidney Disease ◽

Vitamin D Deficiency ◽

Chronic Kidney Disease Stage ◽

Vitamin D Insufficiency ◽

Disease Stage ◽

25 Oh Vitamin D

Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (≥30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)2D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.

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Role of Vitamin D in Prevention of Metabolic Syndrome and Cardiovascular Diseases

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v20i2.51561 ◽

2021 ◽

Vol 20 (2) ◽

pp. 431-438

Author(s):

Raisa Aringazina ◽

Gulnara Kurmanalina ◽

Bakhtiyar Kurmanalin ◽

Tatyana Degtyarevskaya

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Cardiovascular Diseases ◽

Vitamin D3 ◽

Cardiovascular Events ◽

Medical Science ◽

Resistance Index ◽

Duration Of Treatment

Objective: About 90% of cardiovascular diseases can be prevented. In recent years, the role of vitamin D in the prevention of cardiovascular disease and components of metabolic syndrome has been actively discussed. The study aimed to investigate the possible influence of vitamin D3 on the emergence risk of metabolic syndrome and adverse cardiovascular events. Materials and methods: The study enrolled a total of 336 people (170 males and 166 females) aged 50-60 years. For comparative analysis, two groups were formed: Group 1 group involved 150 people treated with placebo, and Group 2 group included 186 people who received vitamin D3 orally in a dose of 2000 IU/day. The duration of treatment and observation was four years. Participants in the study completed a questionnaire developed by the authors of this paper, in which they answered questions about the presence of factors contributing to the development of cardiovascular pathology. Results and Discussion: Daily oral intake of vitamin D3 in a dose of 2000 IU/day for four years did not improve laboratory indicators, which are components of MS, namely, the content in the blood of TC, TG, LDL, HDL, AI, fasting and postprandial glycemia, insulin, and insulin resistance index HOMA2-IR (p>0.05). Prolonged use of vitamin D3 did not reduce the risk of cardiovascular diseases (myocardial infarcts (RR=0.93, 95% CI [0.21-4.09], p=0.92), strokes (RR=1.24, 95% CI [0.18-8.70], p=0.83), stenting (RR=1,23, 95% CI [0.32-4.88], p=0.76), arterial hypertension (RR=1.12, 95% CI [0.47-2.68], p=0.81), as well as cardiovascular death rates (RR=0.83, 95% CI [0.14-4.88], p=0.83) and death from any other causes (RR=0.93, 95% CI [0.21- 4.09], p=0.92). Conclusion: Thus, daily prolonged oral administration of vitamin D3 in a dose of 2000 IU/day does not contribute to the improvement of blood lipid spectrum, glycemia, and insulin resistance in metabolic syndrome and does not reduce the risk of adverse (fatal and non-fatal) cardiovascular events. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.431-438

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