Customizable and regioselective one‐pot N–H functionalization of DNA nucleobases to create a library of nucleobase derivatives for biomedical applications

2021 ◽  
Author(s):  
Djenisa H. A. Rocha ◽  
Carmen M. Machado ◽  
Vera Sousa ◽  
Cristiana F. V. Sousa ◽  
Vera L. M. Silva ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
One Pot ◽  
Dna Nucleobases

One-Pot Synthesis of Iron Oxide Nanoparticles with Functional Silane Shells: A Versatile General Precursor for Conjugations and Biomedical Applications

Langmuir ◽  
2013 ◽  
Vol 29 (34) ◽  
pp. 10850-10858 ◽  
Author(s):  
Vinith Yathindranath ◽  
Zhizhi Sun ◽  
Matthew Worden ◽  
Lynda J. Donald ◽  
James A. Thliveris ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals Ultrabright bimetallic AuAg complex: From luminescence mechanism to biological application

2020 ◽  
Vol 13 (05) ◽  
pp. 2041001 ◽  
Author(s):  
Junchi Chen ◽  
Lingfang Liu ◽  
Haile Liu ◽  
Yonghui Li ◽  
Junying Wang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Biomedical Applications ◽  
Density Functional ◽  
Metal Clusters ◽  
One Pot ◽  
Functional Theory ◽  
Two Photon ◽  
Photon Excitation ◽  
Lowest Unoccupied Molecular Orbital ◽  
Good Biocompatibility

Metal clusters have attracted wide interests due to their unique electronic and optical properties, but the low luminescence quantum yield (QY) prevents them from potential biomedical applications. In this work, silver-doped Au nanoclusters (NCs) are shown to be able to improve the QY of metal clusters. We succeeded in synthesizing ultrabright glutathione (GSH) protected AuAg clusters with 10.8% QY by a one-pot route. Their florescence is about 7.5 times brighter than pure Au NCs, with super photostability and good biocompatibility in physiological environment. Based on density functional theory (DFT) calculations, we investigated the electronic structures and optical properties of the AuAg NCs. The results show that the increase of the density of states of the lowest unoccupied molecular orbital (LUMO) leads to the fluorescence enhancement. In addition, two-photon excitation fluorescence imaging has been performed to show their great potential for biomedicine.

One-pot exfoliation, functionalization, and size manipulation of graphene sheets: efficient system for biomedical applications

2017 ◽  
Vol 33 (4) ◽  
pp. 795-802 ◽  
Author(s):  
Farhad Bani ◽  
Ali Bodaghi ◽  
Abbas Dadkhah ◽  
Soodabeh Movahedi ◽  
Narges Bodaghabadi ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Graphene Sheets ◽  
One Pot ◽  
Efficient System

scholarly journals Red-Emitting SBBF (Single-Benzene-Based Fluorophore)-Silica Hybrid Material: One-Pot Synthesis, Characterization, and Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2036
Author(s):  
Jaehoon Kim ◽  
Jong Min An ◽  
Yuna Jung ◽  
Na Hee Kim ◽  
Youngwoong Kim ◽  
...  
Keyword(s):  
Hybrid Materials ◽  
Hybrid Material ◽  
Biomedical Applications ◽  
Antibacterial Effect ◽  
One Pot ◽  
Bio Imaging ◽  
High Scalability ◽  
Robust Formulation ◽  
First Time ◽  
Further Development

We report, for the first time, a new red-emitting hybrid material based on a single-benzene-based fluorophore (SBBF) and silica. This robust formulation shows several features, including bright emissions at a red wavelength (>600 nm), high scalability (>gram-scale), facile synthesis (one-pot reaction; SBBF formation, hydrolytic condensation, propagation), high stability (under different humidity, pH, light), bio-imaging applicability with low cellular toxicity, and an antibacterial effect within Gram-negative/Gram-positive strains. Based on our findings, we believe that these hybrid materials can pave the way for the further development of dye-hybrid materials and applications in various fields.

scholarly journals One-pot synthesis of oxidation-sensitive supramolecular gels and vesicles

2021 ◽  
Author(s):  
Aroa Duro-Castano ◽  
Laura Rodriguez-Arco ◽  
Lorena Ruiz-Perez ◽  
Cesare De Pace ◽  
Gabriele Marchello ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Sustained Drug Release ◽  
One Pot ◽  
Physiological Conditions ◽  
One Pot Synthesis ◽  
Wide Range ◽  
Spherical Micelles ◽  
The One

Polypeptide-based nanoparticles offer unique advantages from a nanomedicine perspective such as biocompatibility, biodegradability and stimuli-responsive properties to (patho)physiological conditions. Conventionally, self-assembled polypeptide nanostructures are prepared by first synthesizing their constituent amphiphilic polypeptides followed by post-polymerization self-assembly. Herein, we describe the one-pot synthesis of oxidation-sensitive supramolecular micelles and vesicles. This was achieved by polymerization-induced self-assembly (PISA) of the N-carboxyanhydride (NCA) precursor of methionine using polyethylene oxide as stabilizing and hydrophilic block in dimethyl sulfoxide (DMSO). By adjusting the hydrophobic block length and concentration we obtained a range of morphologies from spherical to worm-like micelles, to vesicles. Remarkably, the secondary structure of polypeptides greatly influenced the final morphology of the assemblies. Surprisingly, worm-like micellar morphologies were obtained for a wide range of methionine block lengths and solid contents, with spherical micelles restricted to very short hydrophobic lengths. Worm-like micelles further assembled into oxidation-sensitive, self-standing gels in the reaction pot. Both vesicles and worm-like micelles obtained using this method demonstrated to degrade under controlled oxidant conditions which would expand their biomedical applications such as in sustained drug release or as cellular scaffolds in tissue engineering.

Various Techniques for one pot synthesis of 1,3,5-triazine (s-triazine) derivatives: A Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Sukhbeer Kumari ◽  
Anupama Singh
Keyword(s):  
Biomedical Applications ◽  
Environmentally Benign ◽  
Design And Development ◽  
One Pot ◽  
One Pot Synthesis ◽  
Wide Range ◽  
Triazine Derivatives ◽  
Pharmaceutical Molecules

: Recent studies have shown that one-pot synthesis is a boon for triazines synthesis. One-pot processes had significant success in carrying out complex reactions under mild and eco-friendly conditions. One-pot synthesis is environmentally benign and more economical than other processes in triazines synthesis. The triazine scaffold has provided the starting key point for the design and development of pharmaceutical molecules with wide range of biomedical applications. This review highlights the various methodologies involved for one-pot synthesis of 1,3,5-triazine scaffolds.

scholarly journals The Aquilegia pubiflora (Himalayan columbine) mediated synthesis of nanoceria for diverse biomedical applications

RSC Advances ◽  
2020 ◽  
Vol 10 (33) ◽  
pp. 19219-19231 ◽  
Author(s):  
Hasnain Jan ◽  
Muhammad Aslam Khan ◽  
Hazrat Usman ◽  
Muzamil Shah ◽  
Rotaba Ansir ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Biomedical Applications ◽  
One Pot ◽  
Graphical Illustration

Graphical illustration of eco-friendly, facile, one-pot, green synthesis of nanoceria for multiple biomedical applications.

Thermal Decomposition Synthesis and Assessment of Effects on Blood Cells and In Vivo Damages of Cobalt Ferrite Nanoparticles

2014 ◽  
Vol 28 ◽  
pp. 131-140 ◽  
Author(s):  
Luiz F. Cotica ◽  
Valdirlei F. Freitas ◽  
Daniel M. Silva ◽  
Karina Honjoya ◽  
Karen Honjoya ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Cobalt Ferrite ◽  
Magnetic Measurements ◽  
Drug Carrier ◽  
Current Approach ◽  
Ferrite Nanoparticles ◽  
One Pot ◽  
Synthesis Routes ◽  
Model Drug

In the search to reduce the side effects, toxicity and assuring the desired effectiveness of the drugs, many efforts has been made to improve specific drugs’ delivery characteristics. Several carrier nanoparticles have been used to assist the drugs incorporation, absorption and transport through the bloodstream. However, most chemical synthesis routes are multistep and time-consuming treatments and, also, many carrier nanoparticles have toxic effects. In this work, we report a simple one-pot approach for the synthesis of CoFe2O4 nanoparticles (20 to 100 nm). The magnetic measurements revealed nanoparticles with a magnetic saturation nearly one third of that for bulk CoFe2O4. In vitro assays showed no hemolytic potential and negligible toxicity. By in vivo experiments using adult male mice we found no potential risk alterations by the nanoparticles administration. Therefore, the CoFe2O4 nanoparticles, synthesized by the current approach, can be a model drug-carrier, which makes them useful for the biomedical applications.

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