scholarly journals Predictors of Positive Treatment Outcome in People With Anorexia Nervosa Treated in a Specialized Inpatient Unit: The Role of Early Response to Treatment

2016 ◽  
Vol 24 (5) ◽  
pp. 417-424 ◽  
Author(s):  
Jackie Wales ◽  
Nicola Brewin ◽  
Rebecca Cashmore ◽  
Emma Haycraft ◽  
Jonathan Baggott ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Early Response ◽  
Inpatient Unit ◽  
Response To Treatment ◽  
Positive Treatment

scholarly journals FDG-PET/CT for the Management of Post-Chemotherapy Residual Mass in Hodgkin lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3952
Author(s):  
Andrea Gallamini ◽  
Michał Kurlapski ◽  
Jan Maciej Zaucha
Keyword(s):  
Treatment Outcome ◽  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Quantitative Methods ◽  
Present Review ◽  
Response To Treatment ◽  
Published Evidence ◽  
Pet Ct ◽  
Fdg Pet Ct

In the present review, the authors report the published evidence on the use of functional imaging with FDG-PET/CT in assessing the final response to treatment in Hodgkin lymphoma. Despite a very high overall Negative Predictive Value of post-chemotherapy PET on treatment outcome ranging from 94% to 86%, according to different treatment intensity, the Positive Predicting Value proved much lower (40–25%). In the present review the Authors discuss the role of PET to guide consolidation RT over a RM after different chemotherapy regimens, both in early and in advanced-stage disease. A particular emphasis is dedicated to the peculiar issue of the qualitative versus semi-quantitative methods for End-of Therapy PET scan interpretation. A short hint will be given on the role of FDG-PET to assess the treatment outcome after immune checkpoint inhibitors.

scholarly journals Lifetime Weight Characteristics of Adult Inpatients With Severe Anorexia Nervosa: Maximal Lifetime BMI Predicts Treatment Outcome

2021 ◽  
Vol 12 ◽  
Author(s):  
Lisa-Katrin Kaufmann ◽  
Hanspeter Moergeli ◽  
Gabriella Franca Milos
Keyword(s):  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Strong Predictor ◽  
Negative Influence ◽  
Positive Influence ◽  
The Body ◽  
Linear Regression Models ◽  
Weight Suppression ◽  
Positive Treatment

Background: The body mass index is a key predictor of treatment outcome in patients with anorexia nervosa. In adolescents, higher premorbid BMI is a strong predictor of a favorable treatment outcome. It is unclear whether this relationship holds true for adults with anorexia nervosa. Here, we examine adult patients with AN and investigate the lowest and highest lifetime BMI and weight suppression as predisposing factors for treatment outcome.Methods: We included 107 patients aged 17–56 with anorexia nervosa and tracked their BMI from admission to inpatient treatment, through discharge, to follow-up at 1–6 years. Illness history, including lowest and highest lifetime BMI were assessed prior to admission. We used multiple linear regression models with minimal or maximal lifetime BMI or weight suppression at admission as independent variables to predict BMI at admission, discharge and follow-up, while controlling for patients' age, sex, and duration of illness.Results: Low minimal BMI had a negative influence on the weight at admission, which in turn resulted in a lower BMI at discharge. Higher maximal BMI had a substantial positive influence on BMI at discharge and follow-up. Weight suppression was highly correlated with maximal BMI and showed similar effects to maximal BMI.Conclusion: Our findings strongly support a relationship between low minimal lifetime BMI and lower BMI at admission, and between higher maximal lifetime BMI or weight suppression and a positive treatment outcome, even years after discharge. Overall, maximal BMI emerged as the most important factor in predicting the weight course in adults with AN.

An examination of the role of autonomous versus controlled motivation in predicting inpatient treatment outcome for anorexia nervosa

2016 ◽  
Vol 49 (6) ◽  
pp. 626-629 ◽  
Author(s):  
Lea Thaler ◽  
Mimi Israel ◽  
Juliana Mazanek Antunes ◽  
Sabina Sarin ◽  
David C. Zuroff ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Inpatient Treatment ◽  
Controlled Motivation

Correlation between expression of MCM6, a new proliferative marker, and treatment outcome in patients with Hodgkin's disease

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e19547-e19547
Author(s):  
K. Khodadad ◽  
S. Karimi ◽  
Z. Esfahani Monfared
Keyword(s):  
Treatment Outcome ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Univariate Analysis ◽  
Response To Treatment ◽  
G1 Arrest ◽  
Number Of Patients ◽  
Significant Difference ◽  
Proliferative Marker

e19547 Background: MCM6 is a proliferative marker, which in contrary to Ki67, is involved in all cell cycle phases, including early G1. We evaluated MCM6 expression in Hodgkin's disease (HD) patients in order to find any correlation between MCM6 expression and treatment outcome. Methods: Formalin-fixed paraffin-embedded lymph node specimens of 55 patients with HD treated with ABVD regimen (± radiotherapy) were assessed for MCM6 expression by IHC. The percentage of nuclear positivity in RS and mononuclear Hodgkin cells was evaluated in each case. Clinical data, response to treatment and relapse rates were obtained from patients’ medical records. These data were analyzed by SPSS software. Results: Mean MCM6 expression was 80.7% (ranging 35%-99%) with no significant difference between histology subtypes. In univariate analysis, MCM6 expression was not statistically significant for B-symptoms (P=0.27), sex (P=0.91), stage (P=0.18) and response to treatment (P=0.53), but was significant for age (P=0.008) (≤23 vs >23 yrs old). The MCM6 mean expression between relapsed and non-relapsed groups was marginally significant (21% vs 29.4%, P=0.057). In multivariate analysis, we evaluated MCM6 expression, B-symptoms, stage, response rate and age for relapse. None of risk factors were statistically significant predictor for relapse, including MCM6 expression (P=0.238), however, were significant regarding to response (P<0.001) and stage (P=0.048). We divided patients in 4 quartiles based on their MCM6 expression (Q1<74.25%, N=13, Q2=74.26–85.5%, N=14, Q3=85.6–91.75%, N=13, Q4>91.75%, N=12). Relapse and PFS were not significantly different between these quartiles (P=0.27 and P=0.83, respectively). Conclusions: Our study on a limited number of patients revealed MCM6 is not a strong predictor for treatment outcome in patients with HD. Our findings can be possibly explained by early G1 arrest of tumor cells and the role of cytokine production in pathogenesis of HD. We believe determining the accurate predictive role of proliferative markers needs to be focused on the markers which are exclusively involved in S phase. No significant financial relationships to disclose.

scholarly journals manuscript

2021 ◽  
Author(s):  
Lisa-Katrin Kaufmann
Keyword(s):  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Strong Predictor ◽  
Negative Influence ◽  
Positive Influence ◽  
The Body ◽  
Linear Regression Models ◽  
Weight Suppression ◽  
Positive Treatment

Background: The body mass index is a key predictor of treatment outcome in patients with anorexia nervosa. In adolescents, higher premorbid BMI is a strong predictor of a favourable treatment outcome. It is unclear whether this relationship holds true for adults with anorexia nervosa. Here, we examine adult patients with AN and investigate the lowest and highest lifetime BMI and weight suppression as predisposing factors for treatment outcome.Methods: We included 107 patients aged 17-56 with anorexia nervosa and tracked their BMI from admission to inpatient treatment, through discharge, to follow-up at 1-6 years. Illness history, including lowest and highest lifetime BMI were assessed prior to admission. We used multiple linear regression models with minimal or maximal lifetime BMI or weight suppression at admission as independent variables to predict BMI at admission, discharge and follow-up, while controlling for patients’ age, sex, and duration of illness. Results: Low minimal BMI had a negative influence on the weight at admission, which in turn resulted in a lower BMI at discharge. Higher maximal BMI had a substantial positive influence on BMI at discharge and follow-up. Weight suppression was highly correlated with maximal BMI and showed similar effects to maximal BMI.Conclusion: Our findings strongly support a relationship between low minimal lifetime BMI and lower BMI at admission, and between higher maximal lifetime BMI or weight suppression and a positive treatment outcome, even years after discharge. Overall, maximal BMI emerged as the most important factor in predicting the weight course in adults with AN.

Treatment in Anorexia Nervosa: The Role of Neuropsychological Features in Predicting Response

2017 ◽  
Vol 41 (S1) ◽  
pp. S286-S287
Author(s):  
P. Meneguzzo ◽  
E. Collantoni ◽  
E. Tenconi ◽  
E. Bonello ◽  
G. Croatto ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Behavioral Therapy ◽  
Cognitive Remediation ◽  
Response To Treatment ◽  
Central Coherence ◽  
Clinical Test ◽  
Prediction Ability ◽  
Full Remission ◽  
Neuropsychological Variables

IntroductionNeuropsychological impairments in anorexia nervosa (AN) have been considered both as putative risk factors and as a target for treatment. However, the role of neuropsychological variables as predictors of outcome is not clear.AimsOur aim is to investigate the role of neuropsychological variables as predictors of response to treatment in a group of individuals affected by AN.MethodsThe study sample consisted of 144 patients diagnosed with acute AN, according to the DSM-5 criteria, referred to the Eating Unit of the Hospital of Padova, Italy. All participants were assessed by means of a neuropsychological and clinical test battery at intake and followed during outpatient treatment for an average of 531 days. Eighty-three percent of the patients underwent cognitive behavioral therapy, the families of 75% of the patients were included in the treatment and 48% of the patients took antidepressants (SSRI).ResultsBoth body mass index at assessment and illness duration appeared to be independent factors significantly affecting the outcome. The role of neuropsychological variables was explored including cognitive performance in a multivariate analysis including BMI at intake, duration of illness and diagnostic subtype. The inclusion in the model of the Wisconsin Sorting Card Task performance and the central coherence index (calculated by the Rey Figure Test) significantly increased the prediction ability of the model for full remission at the end of treatment.ConclusionsThis is the first study to show that neuropsychological characteristics may predict treatment response in AN. These data support the implementation of cognitive remediation techniques in the treatment of AN.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Psychological Interventions for Anorexia: Current Challenges

2021 ◽  
Vol 29 (1) ◽  
pp. 184-191
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Outcome Assessment ◽  
Psychological Aspects ◽  
Psychological Interventions ◽  
Psychological Variables ◽  
Novel Methods ◽  
The Impact

The current digest focuses on the psychological aspects of therapy in anorexia nervosa. It reviews publications considering both recognized and novel methods of psychotherapy for anorexia, the role of psychological variables in treatment outcome assessment, the issue of exhausting physical exercising in eating disorders, and the impact of COVID-19 on vulnerable individuals. (Translated by Elena Mozhaeva)

scholarly journals Attachment and mentalization as predictors of outcome in family therapy for adolescent anorexia nervosa

2020 ◽  
Author(s):  
Tom Jewell ◽  
Moritz Herle ◽  
Lucy Serpell ◽  
Alison Eivors ◽  
Mima Simic ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Family Therapy ◽  
Mental States ◽  
Self Report ◽  
Mediating Role ◽  
Poor Outcome ◽  
Positive Treatment ◽  
Adolescent Anorexia Nervosa

Objective: Anorexia nervosa focussed family therapy (FT-AN) is the first-line treatment for adolescent anorexia nervosa (AN), but the predictors of poor treatment response are not well-understood. The main aim of this study was to investigate the role of attachment and mentalization in predicting treatment outcome at nine months. Therapeutic alliance at one month was tested as a potential mediator of the effect of attachment and mentalization at baseline on outcome at nine months.Method: 192 adolescents with AN and their parents were recruited as they began family therapy in out-patient specialist eating disorder services. Self-report measures of attachment, mentalization and emotion regulation were completed at the start of treatment by adolescent patients and one of their parents. Self-reported alliance scores were collected at one month. Results: Higher scores on the Certainty Scale of the Reflective Functioning Questionnaire, completed by parents, which indicate over-certainty about mental states, were the strongest predictor of poor outcome (Odds Ratio: .42, CI: .20 to .87). Similarly, for adolescents, higher Lack of Clarity scores on the Difficulties in Emotion Regulation Scale, representing being unclear about one’s feelings, were predictive of positive treatment outcome (OR: 1.10, CI: 1.00 - 1.21). Alliance scores at one month were predictive of success but did not play a mediating role in relation to baseline predictors.Conclusion: These novel findings suggest that, particularly in parents, a tendency towards inappropriate certainty about mental states in others may predict poor outcome in family therapy for adolescent AN. Further research is warranted to replicate the finding and characterise families at risk of poor outcome.

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