scholarly journals Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: Association with head and neck squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 270-279 ◽  
Author(s):  
Ann Marie Egloff ◽  
Xuwan Liu ◽  
Autumn L. Gaither Davis ◽  
Brian K. Trevelline ◽  
Marike Vuga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Neck Squamous Cell Carcinoma ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Receptor Mrna

scholarly journals Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma

2021 ◽  
Author(s):  
Su Il Kim ◽  
Seon Rang Woo ◽  
Joo Kyung Noh ◽  
Min Kyeong Lee ◽  
Young Chan Lee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mrna Expression ◽  
Gene Mutation ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Possible role for chemokine receptor CCR7 mRNA expression in lymph node metastasis in head and neck squamous cell carcinoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9677-9677
Author(s):  
C. M. Campofiorito ◽  
F. R. R. Mangone ◽  
F. S. Pasini ◽  
S. Maistro ◽  
I. Snitcovsky ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Chemokine Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Node Metastasis

scholarly journals Comprehensive Analysis of Mutation-Based and Expressed Genes-Based Pathways in Head and Neck Squamous Cell Carcinoma

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 792
Author(s):  
Bhumsuk Keam ◽  
Jin Young Park ◽  
Jinpyo Kim ◽  
Gun Do Kim ◽  
Yunsuk Yu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mrna Expression ◽  
Signaling Pathways ◽  
Squamous Cell ◽  
Checkpoint Inhibitors ◽  
Single Gene ◽  
Genetic Alterations ◽  
Neck Squamous Cell Carcinoma

Over- or under-expression of mRNA results from genetic alterations. Comprehensive pathway analyses based on mRNA expression are as important as single gene level mutations. This study aimed to compare the mutation- and mRNA expression-based signaling pathways in head and neck squamous cell carcinoma (HNSCC) and to match these with potential drug or druggable pathways. Altogether, 93 recurrent/metastatic HNSCC patients were enrolled. We performed targeted gene sequencing using Illumina HiSeq-2500 for NGS, and nanostring nCounter® for mRNA expression; mRNA expression was classified into over- or under-expression groups based on the expression. We investigated mutational and nanostring data using the CBSJukebox® system, which is a big-data driven platform to analyze druggable pathways, genes, and protein-protein interaction. We calculated a Treatment Benefit Prediction Score (TBPS) to identify suitable drugs. By mapping the high score interaction genes to identify druggable pathways, we found highly related signaling pathways with mutations. Based on the mRNA expression and interaction gene scoring model, several pathways were found to be associated with over- and under-expression. Mutation-based pathways were associated with mRNA under-expressed genes-based pathways. These results suggest that HNSCCs are mainly caused by the loss-of-function mutations. TBPS found several matching drugs such as immune checkpoint inhibitors, EGFR inhibitors, and FGFR inhibitors.

Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma

2020 ◽  
Vol 19 (17) ◽  
pp. 2072-2078 ◽  
Author(s):  
Nooshin Mohtasham ◽  
Hossein Ayatollahi ◽  
Nasrollah Saghravanian ◽  
Reza Zare ◽  
Mohammad-Taghi Shakeri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mrna Expression ◽  
Sensitivity And Specificity ◽  
Squamous Cell ◽  
Healthy Tissue ◽  
Neck Squamous Cell Carcinoma ◽  
Healthy Individuals ◽  
Expression Levels

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is a common malignancy that is associated with high morbidity and mortality all over the world. We explored the role of mRNA expression of both subunits of LDH in the early diagnosis of HNSCC. Materials and Methods: This was a case-control study on 62 healthy individuals and 62 patients with HNSCC. The expression of LDH in tumors and healthy tissue margins, and in the serum of both HNSCC patients and healthy individuals was evaluated using a quantitative real-time PCR method. Analysis of LDH-A and LDH-B expression and sensitivity-specificity analysis were carried out using SPSS software. Results: mRNA expression levels of LDH-A (4.18±1.29) and LDH-B (2.85±1.07) isoenzymes in tumor tissues were significantly higher than the expressions in the corresponding healthy tissue margins (1.85±0.56 and 1.61±0.56 for LDH-A and LDH-B, respectively). A comparison of LDH-B expression between histological grade I tumor tissue (2.74±0.19) and marginal tissue (1.62±0.90) showed a significant difference (P=0.016). Patients with a positive history of alcohol consumption and cigarette smoking had significantly higher mRNA expression of LDH-A (P=0.024) and LDH-B (P=0.03) in the marginal tissue and blood, respectively. The highest sensitivity and specificity values pertained to the mRNA expression of LDH-A (90.9%) and LDH-B (85.5%) in the blood. Conclusion: This is the first study reporting LDH gene expression as a biomarker in blood and tumoral tissue of HNSCC patients. Given the highest sensitivity and specificity values for LDH-A and LDH-B in blood, we recommend the simultaneous evaluation of both LDH isoenzymes in blood samples as a potential diagnostic method.

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