Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

Head & Neck ◽  
2019 ◽  
Vol 42 (3) ◽  
pp. 539-555 ◽  
Author(s):  
Oreste Iocca ◽  
Thomas P. Sollecito ◽  
Faizan Alawi ◽  
Gregory S. Weinstein ◽  
Jason G. Newman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Transformation Rate ◽  
Oral Dysplasia ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

Human papillomavirus prevalence in oral potentially malignant disorders: systematic review and meta‐analysis

Oral Diseases ◽  
2020 ◽  
Author(s):  
Cecilie D. de la Cour ◽  
Cecilie D. Sperling ◽  
Federica Belmonte ◽  
Stina Syrjänen ◽  
Susanne K. Kjaer
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Meta Analysis ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Predictive value of CCND1 /cyclin D1 alterations in the malignant transformation of potentially malignant head and neck disorders: Systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Potentially Malignant ◽  
Neck Disorders

scholarly journals Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1937 ◽  
Author(s):  
Omar Kujan ◽  
Bede van Schaijik ◽  
Camile S. Farah
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Rates ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). The emerging treatment modality of immunotherapy targets immune checkpoint molecules including PD-1 and its ligand PD-L1, CTLA-4, LAG-3, and TIM-3 to enhance the host immune response against tumours, and to limit the growth and progression of cancer cells. In this systematic review, we searched five databases for keywords pertaining to oral cancers and OPMDs, along with immune checkpoint inhibitors, in order to summarize the current status of their use and efficacy in these diseases. A total of 644 different articles were identified between 2004 and 2019, with 76 deemed suitable for inclusion in the study, providing a total of 8826 samples. Combined results show expression of PD-1 and PD-L1 in the majority of OPMD and OSCC samples, with expression correlating with increased progression and decreased survival rates. Immunotherapy agents pembrolizumab and nivolumab target PD-1 and have been shown to prolong survival rates and improve disease outcomes, especially in combination with chemotherapy or radiotherapy. Despite the equivocal nature of current evidence, there is support for the prognostic and predictive value of immune checkpoint molecules, especially PD-L1, and many studies provide support for the effective use of immune checkpoint inhibitors in the management of OSCC. Limited data is available for OPMD, therefore this should be the focus of future research.

scholarly journals In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (22) ◽  
pp. 11775
Author(s):  
Marta Mazur ◽  
Artnora Ndokaj ◽  
Divyambika Catakapatri Venugopal ◽  
Michela Roberto ◽  
Cristina Albu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Early Diagnosis ◽  
Search Strategy ◽  
Meta Analysis ◽  
Screening Method ◽  
Cochrane Library ◽  
Free Text ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

scholarly journals Malignant transformation rate based stratification model for oral potentially malignant disorders: A potential idea

2020 ◽  
Vol 10 (4) ◽  
pp. 490-491
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Nikunj Maniyar ◽  
Roney Sam Regi ◽  
Aakriti Aruna ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Transformation Rate ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant
Sign in / Sign up

Export Citation Format

Share Document