Human papillomavirus prevalence in oral potentially malignant disorders: systematic review and meta‐analysis

Oral Diseases ◽  
2020 ◽  
Author(s):  
Cecilie D. de la Cour ◽  
Cecilie D. Sperling ◽  
Federica Belmonte ◽  
Stina Syrjänen ◽  
Susanne K. Kjaer
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Meta Analysis ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (22) ◽  
pp. 11775
Author(s):  
Marta Mazur ◽  
Artnora Ndokaj ◽  
Divyambika Catakapatri Venugopal ◽  
Michela Roberto ◽  
Cristina Albu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Early Diagnosis ◽  
Search Strategy ◽  
Meta Analysis ◽  
Screening Method ◽  
Cochrane Library ◽  
Free Text ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta‐analysis

Oral Diseases ◽  
2020 ◽  
Author(s):  
Pablo Ramos‐Garcia ◽  
Maria del Mar Roca‐Rodriguez ◽  
Manuel Aguilar‐Diosdado ◽  
Miguel Angel Gonzalez‐Moles
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Oral Cancer ◽  
Meta Analysis ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis

2018 ◽  
Vol 47 (7) ◽  
pp. 633-640 ◽  
Author(s):  
Fernanda Weber Mello ◽  
Andressa Fernanda Paza Miguel ◽  
Kamile Leonardi Dutra ◽  
André Luís Porporatti ◽  
Saman Warnakulasuriya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1937 ◽  
Author(s):  
Omar Kujan ◽  
Bede van Schaijik ◽  
Camile S. Farah
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Rates ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). The emerging treatment modality of immunotherapy targets immune checkpoint molecules including PD-1 and its ligand PD-L1, CTLA-4, LAG-3, and TIM-3 to enhance the host immune response against tumours, and to limit the growth and progression of cancer cells. In this systematic review, we searched five databases for keywords pertaining to oral cancers and OPMDs, along with immune checkpoint inhibitors, in order to summarize the current status of their use and efficacy in these diseases. A total of 644 different articles were identified between 2004 and 2019, with 76 deemed suitable for inclusion in the study, providing a total of 8826 samples. Combined results show expression of PD-1 and PD-L1 in the majority of OPMD and OSCC samples, with expression correlating with increased progression and decreased survival rates. Immunotherapy agents pembrolizumab and nivolumab target PD-1 and have been shown to prolong survival rates and improve disease outcomes, especially in combination with chemotherapy or radiotherapy. Despite the equivocal nature of current evidence, there is support for the prognostic and predictive value of immune checkpoint molecules, especially PD-L1, and many studies provide support for the effective use of immune checkpoint inhibitors in the management of OSCC. Limited data is available for OPMD, therefore this should be the focus of future research.

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