Is race important in genomic classification of hematological neoplasms?

2021 ◽  
Author(s):  
Huijun Huang ◽  
Junying Wu ◽  
Tiejun Qin ◽  
Zefeng Xu ◽  
Shiqiang Qu ◽  
...  
Keyword(s):  
Hematological Neoplasms

scholarly journals Refractory Anaemia with Ringed Sideroblasts associated with Marked Thrombocytosis – A Study of Four Cases

2008 ◽  
Vol 14 (S3) ◽  
pp. 121-123
Author(s):  
R. Barreira ◽  
R. Ferreira ◽  
J. Cortez ◽  
P. Gameiro ◽  
I. Salazar ◽  
...  
Keyword(s):  
Who Classification ◽  
Myeloproliferative Disorders ◽  
World Health ◽  
Refractory Anaemia ◽  
Diagnostic Features ◽  
Ringed Sideroblasts ◽  
Hematological Neoplasms ◽  
Sideroblastic Anaemia ◽  
Health Organization

Some hematological neoplasms share features of myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD), the World Health Organization (WHO) classification of hematopoietic neoplasms introduced a new separate category: myelodysplastic/myeloproliferative diseases (MDS/MPD). Some patients may present diagnostic features of refractory anaemia with ringed sideroblasts (RARS) together with a markedly elevated platelet count (>600x109/L). Provided that these patients do not have del(5q) nor abnormalities of chromosome 3 (3q21q26) and because features of both myelodysplastic and myeloproliferative processes are present, the WHO classification considers this a provisional entity belonging to the MDS/MPD, unclassifiable category. The so-called provisional entity acquired sideroblastic anaemia associated with thrombocytosis/refractory anaemia with ringed sideroblasts (figure 1) associated with marked thrombocytosis (RARS-T) represents a heterogeneous disease, not only in terms of clinical and morphologic features, but also in terms of cytogenetic and molecular findings.

scholarly journals Cumulative incidence of hematological neoplasms and dynamic of this in different regions of the Cherkasy oblast in 1980, 1989, 2001 and 2014 years

2019 ◽  
Vol 2 (8) ◽  
pp. 69-76
Author(s):  
V.V. Paramonov ◽  
I.S. Diagil
Keyword(s):  
Relative Risk ◽  
Cumulative Incidence ◽  
Nuclear Power ◽  
Chemical Contamination ◽  
Hematological Neoplasms ◽  
Diagnostic Potential ◽  
Ionization Radiation ◽  
Hematologic Neoplasia

The purpose of the study was to analyze the cumulative incidence of hematological neoplasia and evaluate the dynamics of this in different regions of Cherkasy oblast in 1980, 1989, 2001, 2014 yy. Materials and methods. The epidemiological parameters of hematological neoplasms in the radiation-contaminated (RC), chemically contaminated (CC), radiation and chemically contaminated (RCC), conditionally clean (CNC) regions of Cherkassy oblast (CO) in 1980, 1989, 2001, 2014 yy. were analyzed. Classification of CO territories to the RC, CC, RCC, CNC regions was conducted based on reports of the dosimetry certification of all settlements of Ukraine after the Chernobyl accident and the results of determination of the level of chemical contamination by the sanitary and epidemiological service during 1980-2014 yy. Results. It was determined, that, at the limit of statistical significant (p = 0.057), on the RC territory of CO in 2001 year the relative risk for the cumulative incidence of hematologic neoplasia was on 1.41 times higher (18,682 (95 % confidence interval (CI) = 14,426 – 16,879) against 13,187 (95 % CI = 9,495 – 16,879)), compared with CNC region. In addition, in the RC territory from 1989 to 2001 year the increasing at 9,342 times (1,999 (95% CI = 0.69–3.305) versus 18,682 (95% CI = 14.426 – 16.879)) of cumulative incidence of the hematopoietic and lymphoid systems neoplasm was detected. It is proved, that in the CNC region from 2001 to 2014 year at 1,791 times (13,187 (95% CI = 9.495 – 16.879) versus 23,619 (95% CI = 18.412 – 28.826)) higher level of the cumulative incidence of hematologic neoplasia was observed. Conclusions. In the CO, which was polluted by the radiation factor because of the Chernobyl nuclear power plant accident, 5 years after that, in 2001 was detected the increasing of the relative risk of hematologic neoplasia, compared to that on the CNC region. In addition, on the RC territory from 1989 to 2001 year the increasing at 9,342 times of the incidence of hematopoietic and lymphoid system tumors was observed. This is evidence of pro-leukemic effects of ionization radiation and, probably, the increase in the diagnostic potential of the hematological service of the CO.

Acute Biphenotypic Leukemia: Single Center Experience of Laboratory Presentation and Review of the Diagnostic Criteria.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4404-4404
Author(s):  
Tarek M. Owaidah ◽  
Amal Al Behani ◽  
Mohammed Anwar Iqbal ◽  
Nasser El Kum ◽  
George T. Roberts
Keyword(s):  
Philadelphia Chromosome ◽  
Pediatric Leukemia ◽  
Cell Markers ◽  
Single Center Experience ◽  
Hematological Neoplasms ◽  
Alive With Disease ◽  
Immunological Classification ◽  
The Mean ◽  
Normal Cytogenetics

Abstract Biphenotypic Acute Leukemia (BAL) is a rare, newly defined disease in the WHO classification of hematological neoplasms. There is little information about the laboratory presentation, and considerable difficulties exist in reaching a definite diagnosis. In this study, designed to examine the laboratory presentation of BAL, we report a total of 23 (3.4%) out of 676 adult and pediatric leukemia cases referred to our center during the last 4 years. The mean age at presentation was (21.57 ± 15.59 years; range 1 year – 66 years). There were 14 males. The mean hematological and biochemical parameters were as follows: WBC 68.76 ± 65.18 x 10 9/L, Hemoglobin 94.13 ± 15.13 g/L, Platelets 105.7 ± 104.23 x 10 9/L, and LDH 1351.44 ± 1118.29 u/L. Fourteen patients (60.8%) had mixed morphology of small and large blast cells and seven were M1 and M2 according to FAB criteria. Using the European Group for Immunological Classification of Leukemia (EGIL) scoring system, all patients had positive Myeloid markers with EGIL scores that ranged from 2.0 – 5.5. Eighteen patients were positive for B-cell markers with scores ranging from 2.0 – 8.5 but only 8 patients were positive for T-cell markers with scores of 0.5 – 4.0. Three patients were positive for markers of the three cell lines. In 7 patients myeloid lineage commitment was also demonstrable by ultrastructural myeloperoxidase. Five patients (22%) had normal cytogenetics. Philadelphia chromosome was positive by karyotype in 3 patients (13%) and MLL gene in 2 (8.7%). Three patients (13%) demonstrated trisomies involving chromosomes 19, 22 and 4, respectively. Out of the 23 patients, 11 (48%) are alive without disease, 4 had died with leukemia, 3 are alive with disease and 5 had lost follow up.

Note on the spectral classification of carbon stars in the photographic infrared region

1966 ◽  
Vol 24 ◽  
pp. 21-23
Author(s):  
Y. Fujita
Keyword(s):  
Infrared Region ◽  
Spectral Classification ◽  
Carbon Stars

We have investigated the spectrograms (dispersion: 8Å/mm) in the photographic infrared region fromλ7500 toλ9000 of some carbon stars obtained by the coudé spectrograph of the 74-inch reflector attached to the Okayama Astrophysical Observatory. The names of the stars investigated are listed in Table 1.

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

Ultrastructure of mesotheliomas

1984 ◽  
Vol 42 ◽  
pp. 98-101
Author(s):  
Irving Dardick
Keyword(s):  
Electron Microscopy ◽  
Latent Period ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
Metastatic Adenocarcinoma ◽  
Cell Sarcoma ◽  
Cytological Features ◽  
Industrial Use ◽  
Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

Interpreting HVEM of muscle-cell impulse networks

1992 ◽  
Vol 50 (1) ◽  
pp. 126-127
Author(s):  
Paul DeCosta ◽  
Kyugon Cho ◽  
Stephen Shemlon ◽  
Heesung Jun ◽  
Stanley M. Dunn
Keyword(s):  
Structural Analysis ◽  
Muscle Cell ◽  
Electron Micrographs ◽  
Relative Size ◽  
Automatic Classification ◽  
Nerve Fibers ◽  
Analysis Algorithm ◽  
Structural Networks

Introduction: The analysis and interpretation of electron micrographs of cells and tissues, often requires the accurate extraction of structural networks, which either provide immediate 2D or 3D information, or from which the desired information can be inferred. The images of these structures contain lines and/or curves whose orientation, lengths, and intersections characterize the overall network.Some examples exist of studies that have been done in the analysis of networks of natural structures. In, Sebok and Roemer determine the complexity of nerve structures in an EM formed slide. Here the number of nodes that exist in the image describes how dense nerve fibers are in a particular region of the skin. Hildith proposes a network structural analysis algorithm for the automatic classification of chromosome spreads (type, relative size and orientation).

Dual stain kit for the microscopic gram classification of ocular infection bacteria

1993 ◽  
Vol 51 ◽  
pp. 248-249
Author(s):  
Jacob S. Hanker ◽  
Dale N. Holdren ◽  
Kenneth L. Cohen ◽  
Beverly L. Giammara
Keyword(s):  
Contact Lenses ◽  
Ocular Infection ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Gram Staining ◽  
Ocular Infections ◽  
Different Types ◽  
Culture Positive ◽  
Increased Susceptibility

Keratitis and conjunctivitis (infections of the cornea or conjunctiva) are ocular infections caused by various bacteria, fungi, viruses or parasites; bacteria, however, are usually prominent. Systemic conditions such as alcoholism, diabetes, debilitating disease, AIDS and immunosuppressive therapy can lead to increased susceptibility but trauma and contact lens use are very important factors. Gram-negative bacteria are most frequently cultured in these situations and Pseudomonas aeruginosa is most usually isolated from culture-positive ulcers of patients using contact lenses. Smears for staining can be obtained with a special swab or spatula and Gram staining frequently guides choice of a therapeutic rinse prior to the report of the culture results upon which specific antibiotic therapy is based. In some cases staining of the direct smear may be diagnostic in situations where the culture will not grow. In these cases different types of stains occasionally assist in guiding therapy.

Ultrastructural Classification of Pituary Adenomas

1990 ◽  
Vol 48 (3) ◽  
pp. 258-258
Author(s):  
S. Arumugam ◽  
Sarasa Bharati Arumugam
Keyword(s):  
Cytoplasmic Organelle ◽  
Null Cell ◽  
Cell Adenoma ◽  
Mixed Cell ◽  
Light Microscope Level ◽  
Null Cell Adenoma ◽  
Growth Hormone Cell ◽  
Ultrastructural Characteristics ◽  
Organelle Morphology

Adenoaas of the pituitary are no longer classified based on their tinctorial affinity to dyes. With the advent of the newer methods of sophisticated technology, it is now possible to classify. These depending upon the type of hormone secreted based either on histochemical techniques or on ultrastructural characteristics. The latter provides an insight into the cytoplasmic organelle morphology which offers a delightful feast to the eye as well.This paper presents the ultrastructural characters of the pituitary adenoma as seen in Madras. 171 adenomas (124 males and 47 females) were seen during 1972-1989, classified at the light microscope level as 159 chromophobe, 2 basophilic, 4 eosinophilic and 6 mixed adenomas.Ultrastructural examination showed that the sparsely granular prolactin cell adenoma is the commonest adenoma to be encountered closely followed by the growth hormone cell adenoma, null cell adenoma, the mixed cell adenoma and others.

Consistency in Latency Measurements and Interpretation of ABR Tracings

1997 ◽  
Vol 6 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Wayne O. Olsen ◽  
Terri L. Pratt ◽  
Christopher D. Bauch
Keyword(s):  
The Other

Multichannel ABR recordings for 30 otoneurologic patients were reviewed independently by three audiologists to assess interjudge consistency in determining absolute latencies and overall interpretation of ABR results. Four months later, the tracings were reviewed a second time to evaluate intrajudge consistency in interpretation of ABR waveforms. Interjudge agreement in marking latencies for waves I, III, and V within 0.2 ms was on the order of 90% or better. Intrajudge consistency was slightly higher. Only rarely did inter- or intrajudge differences in latency measurements exceed 0.3 ms. Agreement in overall interpretation of ABR results as "normal" or "abnormal" was unanimous for 90% of the patients. Across pairs of judges, the agreement for "normal" and "abnormal" classification of the ABR tracings was 97%. Intrajudge consistency for "normal" and "abnormal" categorization of the ABR results was 100% for one judge, 97% for the other two judges.

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