Risk of bladder cancer by source and type of tobacco exposure: A case-control study

Abstract Introduction: Trichomonas vaginalis infection is one of the most widespread sexually transmitted infections in the world. There are approximately 276 million cases worldwide. Most men remain undiagnosed and untreated because they are asymptomatic. The chronic inflammation induced by persistent infection may increase the risk of developing genitourinary cancers. In this study, we aimed to investigate the association between trichomoniasis and benign prostate hyperplasia (BPH), prostate cancer (PCa), and bladder cancer (BC) in Taiwan.Material and method: We designed a case-control study by using the database of the National Health Insurance program in Taiwan. We used the International Classification of Diseases, 9th Revision classifications to classify all the medical conditions in the case and control groups. All odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed using multivariable logistic regression to adjust for all comorbidities and variables.Result: From 2000 to 2015, we enrolled a total of 62,544 individuals as the case group and 187,632 as the control group. Trichomoniasis exposure had a significant association with BPH and PCa (adjusted OR: BPH = 2.685, 95% CI = 1.233–4.286, P = 0.013; PCa = 5.801, 95% CI = 1.296–26.035, P = 0.016). The relative risk was much higher if patients had both trichomoniasis and depression (adjusted OR = 7.682, 95% CI = 5.730–9.451, P < 0.001).Conclusion: Men with trichomoniasis had a significantly higher risk of developing BPH and PCa than those without. Healthcare professionals should not only pay more attention to disease treatment, but also to public health education.

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Occupation, smoking, opium, and bladder cancer: A case–control study

South Asian Journal of Cancer ◽

10.4103/2278-330x.173174 ◽

2015 ◽

Vol 04 (03) ◽

pp. 111-114 ◽

Cited By ~ 3

Author(s):

Tayeb Ghadimi ◽

Bahman Gheitasi ◽

Sayran Nili ◽

Mohammad Karimi ◽

Ebrahim Ghaderi

Keyword(s):

Bladder Cancer ◽

Risk Factor ◽

Cigarette Smoking ◽

Case Control Study ◽

Case Control ◽

Cancer Drug ◽

Control Group ◽

Occupational Risk Factors ◽

Opium Abuse ◽

Control Study

Abstract Purpose: The aim of this study was to investigate occupational risk factors associated with bladder cancer. Materials and Methods: In this case–control study, control group included patients who referred to a specialized clinic in the same city and hospitals where patients had been registered. Data were entered into SPSS software. Odds ratios (OR) were calculated for occupational variables and other characteristics. Then, using logistic regression, the association between cancer and drugs was studied while smoking was controlled. Results: Cigarette smoking, even after quitting, was also associated with bladder cancer (OR = 2.549). Considering the classification of occupations, the OR of working in metal industry in patients was 10.629. Multivariate analysis showed that use of the drug by itself can be a risk factor for bladder cancer. Drug abuse together with the control of smoking increased the risk of bladder cancer by 4.959. Conclusion: According to the findings of this study, contact with metal industries such as welding, and working with tin was found as a risk factor for bladder cancer. In addition, cigarette smoking and opium abuse individually were associated with bladder cancer.

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Identification of Occupational Cancer Risks In British Columbia: A Population-Based Case–Control Study of 1129 Cases of Bladder Cancer

Journal of Occupational and Environmental Medicine ◽

10.1097/01.jom.0000169094.77036.1d ◽

2005 ◽

Vol 47 (8) ◽

pp. 854-858 ◽

Cited By ~ 26

Author(s):

Pierre R. Band ◽

Nhu D. Le ◽

Amy C. MacArthur ◽

Raymond Fang ◽

Richard P. Gallagher

Keyword(s):

British Columbia ◽

Bladder Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Occupational Cancer ◽

Cancer Risks ◽

Control Study

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Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2013.11.014 ◽

2014 ◽

Vol 274 (2) ◽

pp. 225-231 ◽

Cited By ~ 63

Author(s):

Dawit Melak ◽

Catterina Ferreccio ◽

David Kalman ◽

Roxana Parra ◽

Johanna Acevedo ◽

...

Keyword(s):

Bladder Cancer ◽

Case Control Study ◽

Case Control ◽

Northern Chile ◽

Arsenic Methylation ◽

Control Study

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Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

Occupational and Environmental Medicine ◽

10.1136/oemed-2017-104666 ◽

2018 ◽

Vol 75 (5) ◽

pp. 328-336 ◽

Cited By ~ 5

Author(s):

Régis Colin ◽

Michel Grzebyk ◽

Pascal Wild ◽

Guy Hédelin ◽

Ève Bourgkard

Keyword(s):

Bladder Cancer ◽

Occupational Exposure ◽

Case Control Study ◽

Occupational Exposures ◽

Case Control ◽

Metalworking Fluids ◽

Cumulative Exposure ◽

Cancer Case ◽

Increased Risk ◽

Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

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Association of MTHFD Gene Polymorphisms and Maternal Smoking With Risk of Congenital Heart Disease: A Hospital-Based Case-Control Study

10.21203/rs.3.rs-650881/v1 ◽

2021 ◽

Author(s):

Xinli Song ◽

Qiongxuan Li ◽

Jingyi Diao ◽

Jinqi Li ◽

Yihuan Li ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Maternal Smoking ◽

Congenital Heart ◽

Case Control Study ◽

Interaction Effects ◽

Case Control ◽

Tobacco Exposure ◽

Maternal Tobacco Exposure ◽

Control Study

Abstract Background: MTHFD may affect the embryonic development by elevated homocysteine levels, DNA synthesis and DNA methylation, but limited number of genetic variants of MTHFD was focused on the association with congenital heart disease (CHD). This study examined the role of MTHFD and maternal smoking in CHD risk, and investigated their interaction effects in Chinese populations. Methods: A case-control study of 464 mothers of CHD infants and 504 mothers of health controls was performed. The exposures of interest were maternal tobacco exposure, single nucleotide polymorphisms (SNPs) of maternal MTHFD gene. The logistic regression model was used for accessing the strength of association.Results: Mothers exposed to secondhand smoke during three months before pregnancy (adjusted odds ratio [aOR] = 1.56; 95% confidence interval [CI]: 1.13-2.15) and in the first trimester of pregnancy (aOR = 2.24; 95%CI: 1.57-3.20) were observed an increased risk of CHD. Our study also found that polymorphisms of maternal MTHFD gene at rs1950902 (AA vs. GG: aOR = 1.73, 95% CI: 1.01-2.97), rs2236222 (GG vs. AA: aOR = 2.38, 95% CI: 1.38-4.12), rs1256142 (GA vs.GG: aOR = 1.57, 95% CI: 1.01-2.45) and rs11849530 (GG vs. AA: aOR = 1.68, 95% CI: 1.02-2.77) were significantly associated with higher risk of CHD. Furthermore, we found the different degrees of interaction effects between polymorphisms of the MTHFD gene including rs1950902, rs2236222, rs1256142, rs11849530 and rs2236225, and maternal tobacco exposure.Conclusions: Maternal polymorphisms of MTHFD gene at rs1950902, rs2236222, rs1256142 and rs11849530, maternal tobacco exposure and their interactions are significantly increased the risk of CHD in offspring. However, more studies in different ethnic populations with a larger sample and prospective designs are required to confirm our findings.Trial registration: Registration number: ChiCTR1800016635; http://www.chictr.org.cn/edit.aspx?pid=28300&htm=4

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