scholarly journals Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

2018 ◽  
Vol 75 (5) ◽  
pp. 328-336 ◽  
Author(s):  
Régis Colin ◽  
Michel Grzebyk ◽  
Pascal Wild ◽  
Guy Hédelin ◽  
Ève Bourgkard
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Metalworking Fluids ◽  
Cumulative Exposure ◽  
Cancer Case ◽  
Increased Risk ◽  
Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

scholarly journals A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men

2014 ◽  
Vol 71 (10) ◽  
pp. 667-674 ◽  
Author(s):  
Joanne S Colt ◽  
Melissa C Friesen ◽  
Patricia A Stewart ◽  
Park Donguk ◽  
Alison Johnson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Metalworking Fluids ◽  
Bladder Cancer Risk ◽  
Control Study

scholarly journals 0084 A Case-Control Study of Occupational Exposure to Metalworking Fluids and Bladder Cancer Risk among Men

2014 ◽  
Vol 71 (Suppl 1) ◽  
pp. A71.1-A71
Author(s):  
Joanne Colt ◽  
Melissa Friesen ◽  
Patricia Stewart ◽  
Park Donguk ◽  
Alison Johnson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Metalworking Fluids ◽  
Bladder Cancer Risk ◽  
Control Study

scholarly journals Occupational and Environmental Risk Factors for Idiopathic Pulmonary Fibrosis: A Multicenter Case-Control Study

2000 ◽  
Vol 152 (4) ◽  
pp. 307-315 ◽  
Author(s):  
Kathy B. Baumgartner ◽  
Jonathan M. Samet ◽  
David B. Coultas ◽  
Christine A. Stidley ◽  
William C. Hunt ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Geographic Region ◽  
Unknown Etiology ◽  
Occupational Factors ◽  
Increased Risk ◽  
Control Study

Abstract Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20–75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3); metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments. Am J Epidemiol 2000;152:307–15.

scholarly journals Risk of Alcohol Consumption in Bladder Cancer: Case-Control Study from a Nationwide Inpatient Database in Japan

2016 ◽  
Vol 239 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Masayoshi Zaitsu ◽  
Fumiaki Nakamura ◽  
Satoshi Toyokawa ◽  
Akiko Tonooka ◽  
Takumi Takeuchi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Alcohol Consumption ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Case ◽  
Bladder Cancer Case ◽  
Inpatient Database ◽  
Control Study

Asbetos Exposure, Physical Activity and Colon Cancer: A Case-Control Study

1993 ◽  
Vol 79 (5) ◽  
pp. 301-303 ◽  
Author(s):  
Paolo Vineis ◽  
Giovannino Ciccone ◽  
Assunta Magnino
Keyword(s):  
Physical Activity ◽  
Colon Cancer ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Northern Italy ◽  
Car Industry ◽  
Job Titles ◽  
Control Study

Aims and Background An association between colon cancer and the occupation of model or pattern maker in the car industry has been repeatedly suggested. The aim of our study was to investigate colon cancer and occupational exposures (in particular in the car industry) in an industrialized area of northern Italy. Methods We conducted a hospital-based case-referent study on colon cancer (n = 131; hospital controls, n = 463). All subjects were interviewed, and jobs in the car industry were investigated. Occupational exposure to asbestos and the level of physical activity were blindly assessed. All the jobs were classified according to energy expenditure (less than 8, 8-12 and more than 12 kJ/min). Results We found no association between colon cancer and any job in the car industry. No subject had worked as a model or pattern maker. Sedentary work was associated with colon cancer in men but not in women. An excess risk was demonstrated among males for job titles involving putative exposure to asbestos (4 cases and 3 controls; OR = 4.8, 95 % c.i. 1.05-21.5), in particular pipe fitters and boilermakers (3 cases and 1 control; OR = 10.7; 1.07-103).

scholarly journals Sarcoidosis and silica dust exposure among men in Sweden: a case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038926
Author(s):  
Pål Graff ◽  
Johanna Larsson ◽  
Ing-Liss Bryngelsson ◽  
Pernilla Wiebert ◽  
Per Vihlborg
Keyword(s):  
Occupational Exposure ◽  
Case Control Study ◽  
Older Men ◽  
Case Control ◽  
Dust Exposure ◽  
Control Analysis ◽  
Silica Exposure ◽  
Silica Dust ◽  
Increased Risk ◽  
Control Study

ObjectiveTo determine whether occupational exposure to silica dust is associated with an increased risk of developing sarcoidosis.DesignCase–control study of all individuals between 20 and 65 years of age diagnosed with sarcoidosis (D86) in Sweden between 2007 and 2016. Controls were matched to cases (2:1) based on age, sex and county at the time of diagnosis. A Job Exposure Matrix was used to estimate the occupational silica exposure of all cases and controls.SettingMedical and occupational data from the National Outpatient Register were used to implement a case–control analysis, while the two controls used for each case were selected from the National Register of the Total Population. Information about occupation and time of employment were collected from the Swedish Occupational Register.ParticipantsAll men and women aged 20–65 years old who were diagnosed sarcoidosis (D86) from 2007 to 2016 were included and assigned two controls.Main outcomesSilica dust exposure correlates with an increased risk of developing sarcoidosis in men.ResultsThe prevalence of silica exposure at work was statistically significantly higher among male cases than controls (OR 1.27, 95% CI 1.13 to 1.43). For men of an age of 35 years or younger the correlation seems to be stronger (OR 1.48, 95% CI 1.1 to 1.87) than in older men (OR 1.21, 95% CI 1.05 to 1.39). For men older than 35 with exposure to silica the prevalence of sarcoidosis increased with the exposure time, with an OR of 1.44 (95% CI 1.04 to 2.00) for exposure of more than 10 years.ConclusionsOccupational exposure to silica dust seems to increase the risk of sarcoidosis among men between 20 and 65 years of age. The risk is higher among exposed men 35 years or younger and older men with longer exposure (>6 years).

Occupational Exposure to Glyphosate and Risk of Lymphoma: Results of an Italian Multicenter Case-Control Study

2020 ◽  
Author(s):  
Federico Meloni ◽  
Giannina Satta ◽  
Marina Padoan ◽  
Andrea Montagna ◽  
Ilaria Pilia ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Case Control Study ◽  
B Cell Lymphoma ◽  
Case Control ◽  
Cumulative Exposure ◽  
International Agency ◽  
Exposure Level ◽  
High Exposure ◽  
Human Carcinogen ◽  
Control Study

Abstract BackgroundThe International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy. MethodsThe Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011-17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre. ResultsVery few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 x 10-4. There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL. ConclusionsOur findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen.

Case–control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix

2017 ◽  
Vol 75 (4) ◽  
pp. 290-295 ◽  
Author(s):  
Sonia El-Zaemey ◽  
TN Anand ◽  
Jane Shirley Heyworth ◽  
Terry Boyle ◽  
Martie van Tongeren ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Case Control ◽  
Cumulative Exposure ◽  
Job Exposure Matrix ◽  
Occupational History ◽  
Occupational Risk Factors ◽  
Western Australian ◽  
Control Study

BackgroundColorectal cancer is the third most prevalent cancer in the world and is twice as common in developed countries when compared with low-income and middle-income countries. Few occupational risk factors for colorectal cancer have been identified. This case–control study aimed to assess the association between colorectal cancer and occupational exposure to selected solvents, combustion products, metals, dusts and other agents.MethodsCases (n=918) were enrolled from the Western Australian Cancer Registry from June 2005 to August 2007. Controls (n=1021) were randomly selected from the Western Australian electoral roll. We collected lifetime occupational history from cases and controls, in addition to their demographic and lifestyle characteristics. We applied the INTEROCC job exposure matrix to convert the occupational history to occupational exposure for 18 selected agents. Three exposure indices were developed: (1) exposed versus non-exposed; (2) lifetime cumulative exposure; and (3) total duration of exposure. The associations between colorectal cancer and the selected agents were estimated using logistic regression models adjusting for sex and age.ResultsNone of the 18 selected agents showed an association with colorectal cancer. No dose–response relationships with lifetime cumulative exposure or duration of exposure were observed.ConclusionThere was no evidence to suggest that occupational exposure to 18 selected agents increased the risk of colorectal cancer.

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