Risk factors for endometrial cancer: An umbrella review of the literature

Abstract Background The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

Download Full-text

Systemic recurrence of endometrial cancer more than 10 years after hysterectomy: a report of two cases and a brief review of the literature

Journal of the Egyptian National Cancer Institute ◽

10.1186/s43046-020-00052-2 ◽

2020 ◽

Vol 32 (1) ◽

Author(s):

Leonardo Muratori ◽

Paola Sperone ◽

Gabriella Gorzegno ◽

Anna La Salvia ◽

Giorgio Vittorio Scagliotti

Keyword(s):

Endometrial Cancer ◽

Case Report ◽

Endometrial Carcinoma ◽

Developed Countries ◽

Disease Stage ◽

Prior History ◽

Disease Relapse ◽

Review Of The Literature ◽

Radical Treatment ◽

Risk Of Disease

Abstract Background Endometrial carcinoma is one of the most common female cancers in developed countries. Disease stage is associated with the risk of disease relapse after radical treatment. Typically, the risk of disease relapse peaks at 3 years from local radical treatment and then diminishes over time, so that late relapses (i.e., from year 5 afterward) are extremely infrequent. Here, we report two cases of women with endometrial cancer who developed a disease relapse more than 15 years after radical treatment. A review of the literature revealed other seven reports of women with relapse from endometrial cancer occurring more than 10 years after radical treatment. Case presentation Case report 1 is a 56-year-old woman with an endometrioid cancer who underwent a hysterectomy with bilateral salpingo-oophorectomy in 1998. She relapsed in the lung in 2014, 16 years from radical surgery. Case report 2, a 75-year-old woman, with an endometrioid cancer, was treated by hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy. The disease relapse in the lung was detected in 2019, 22 years from radical treatment. Conclusion Although guidelines do not support oncological follow-up beyond 5 years from surgery, oncologists should consider late recurrence of endometrial carcinoma in the differential diagnosis of women presenting with metastases of uncertain origin and prior history of this disease.

Download Full-text

Risk Factors for Young Premenopausal Women With Endometrial Cancer

Obstetrics and Gynecology ◽

10.1097/01.aog.0000154151.14516.f7 ◽

2005 ◽

Vol 105 (3) ◽

pp. 575-580 ◽

Cited By ~ 181

Author(s):

Pamela T. Soliman ◽

Jonathan C. Oh ◽

Kathleen M. Schmeler ◽

Charlotte C. Sun ◽

Brian M. Slomovitz ◽

...

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Premenopausal Women

Download Full-text

TRANSIENT ISCHEMIC ATTACKS: ETIOPATHOGENESIS, CLINIC. (Literature review)

Vestnik ◽

10.53065/kaznmu.2021.32.28.017 ◽

2021 ◽

pp. 91-96

Author(s):

Г.Ж. Жакенова ◽

Р.Б. Нуржанова ◽

К.Б. Сраилова ◽

Ж.С. Шерияздан ◽

А.Б. Ташманова ◽

...

Keyword(s):

Risk Factors ◽

Differential Diagnosis ◽

Literature Review ◽

Clinical Manifestations ◽

Transient Ischemic Attacks ◽

Review Of The Literature ◽

Imaging Signs

В данной статье представлен обзор литературы по транзиторным ишемическим атакам: эпидемиология, этиология, патогенез, классификация, основные характеристики с учетом факторов риска, визуализационных признаков МРТ и КТ, клинических проявлений и дифференциальной диагностики данного заболевания на основе современных исследований. This article presents a review of the literature on transient ischemic attacks: epidemiology, etiology, pathogenesis, classification, main characteristics taking into account risk factors, imaging signs of MRI and CT, clinical manifestations and differential diagnosis of this disease based on modern research.

Download Full-text