Low Plasma Level of Leucine-Rich Repeat-Containing 17 (LRRc17) Is an Independent and Additive Risk Factor for Osteoporotic Fractures in Postmenopausal Women

Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk factor for NASH progression, is often observed after menopause. This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high-fat and high-cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 wk. Next, to investigate the effects of exogenous estrogen replenishment, OVX mice fed with HFHC diet were treated with implanted hormone release pellets (containing 17β-estradiol or placebo vehicle) for 6 wk. OVX mice on the HFHC diet showed enhanced liver injury with increased liver macrophage infiltration and elevated serum cholesterol levels compared with SO-HFHC mice. Hepatocyte monocyte chemoattractant protein-1 (MCP1) protein expression in OVX-HFHC mice was also enhanced compared with SO-HFHC mice. In addition, hepatic inflammatory gene expressions, including monocytes chemokine (C-C motif) receptor 2 (CCR2), were significantly elevated in OVX-HFHC mice. Estrogen treatment improved serum cholesterol levels, liver injury, macrophage infiltration, and inflammatory gene expressions in OVX-HFHC mice. Moreover, the elevated expression of liver CCR2 and MCP1 were decreased by estrogen treatment in OVX-HFHC mice, whereas low-density lipoprotein dose dependently enhanced CCR2 expression in THP1 monocytes. Our study demonstrated that estrogen deficiency accelerated NASH progression in OVX mice fed HFHC diet and that this effect was improved by estrogen therapy. Hypercholesterolemia in postmenopausal women would be a potential risk factor for NASH progression.

Download Full-text

The anti-osteoporosis effects of Vitamin K in postmenopausal women

Current Stem Cell Research & Therapy ◽

10.2174/1574888x16666210512020103 ◽

2021 ◽

Vol 16 ◽

Author(s):

Yuan Liu ◽

Yuan He ◽

Baorong He ◽

Lingbo Kong

Keyword(s):

Postmenopausal Women ◽

Vitamin K ◽

Relevant Literature ◽

Osteoporotic Fractures ◽

Mortality And Morbidity ◽

Standard Guideline ◽

Set Up ◽

Meta Analyses ◽

Aging People ◽

Analytical Approaches

Abstract: As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Therefore, the present review aimed to systematically reviewed published literature on the role of vitamin K in the treatment of osteoporosis. We currently, via multiple queries strategy, searched the relevant literature in Cochrane and PubMed from January 2010 to December 2019. Subsequently, we conducteda systematic review according to the standard guideline of Preferred Reporting Item for Systematic Reviews and Meta-Analyses [PRISMA]. Finally, ten relevant works of literature met our current criteria for inclusion, and then we followed the PRISMA guideline and systematically reviewed each study by the categorized data sources and analytical approaches in each study, meanwhile set up variables and defined each study outcomes.

Download Full-text

THE UTILITY OF TBS-ADJUSTED BMD T-SCORE IN THE DISCRIMINATION OF THE MAJOR OSTEOPOROTIC FRACTURES IN THE POSTMENOPAUSAL WOMEN OF THE ROTTERDAM AND THE OSTEOLAUS STUDIES

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2018.05.034 ◽

2018 ◽

Vol 21 (4) ◽

pp. 610

Author(s):

Enisa Shevroja ◽

Fjorda Koromani ◽

William D. Leslie ◽

Olivier Lamy ◽

Fernando Rivadeneira ◽

...

Keyword(s):

Postmenopausal Women ◽

Osteoporotic Fractures ◽

T Score ◽

Major Osteoporotic Fractures

Download Full-text

Does Bone Mineral Apparent Density Predict Osteoporotic Fractures in Lebanese Postmenopausal Women?

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2014.04.088 ◽

2014 ◽

Vol 17 (3) ◽

pp. 423

Author(s):

R. El Hage ◽

A. Sebaaly ◽

M. Issa ◽

F. Bachour ◽

E. Zakhem ◽

...

Keyword(s):

Postmenopausal Women ◽

Bone Mineral ◽

Apparent Density ◽

Osteoporotic Fractures ◽

Bone Mineral Apparent Density

Download Full-text

Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

Biology ◽

10.3390/biology10111139 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1139

Author(s):

Ewelina Anna Dziedzic ◽

Wiktor Smyk ◽

Izabela Sowińska ◽

Marek Dąbrowski ◽

Piotr Jankowski

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Risk Factor ◽

Coronary Artery ◽

Serum Level ◽

Postmenopausal Women ◽

Coronary Atherosclerosis ◽

History Of ◽

Artery Disease ◽

The Impact

Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.

Download Full-text

Association Between moleculars and Osteoporotic Fracture Risk:A systematical review

10.1101/2020.03.31.20049429 ◽

2020 ◽

Author(s):

Jie-Yu Liu ◽

Jia-Xiang Wang ◽

Li Xu ◽

Shu-Feng Lei ◽

Fei-Yan Deng

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Elderly Population ◽

Early Recognition ◽

Osteoporotic Fractures ◽

Middle Aged ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Increased Risk

AbstractOsteoporosis is a systemic chronic skeletal disease, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs). OFs are associated with high mortality and morbidity, and seriously affect the life quality of patients. Osteoporosis is prevalent in the middle-aged and elderly population, especially the postmenopausal women. With population aging, osteoporosis becomes a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing OFs. In light of the high heritability and complex pathogenesis of OP, comprehensive consideration of significant biological/biochemical factors is necessary for accurate risk evaluation. For this purpose, we reviewed recent research progress on moleculars which are diagnostic and/or predictive of OFs risk. Future integrative analyses and systematic evaluation of these moleculars may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence to contribute to preventing OFs in the world.Graphical AbstractOsteoporosis, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs), is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. We focused on several types of important molecules, including proteins/peptides, RNAs, lipids, to gain comprehensive understanding and to generate novel perspectives in predicting and diagnosing OFs.

Download Full-text