Triptolide inhibits CD133 + /CD44 + colon cancer stem cell growth and migration through triggering apoptosis and represses epithelial‐mesenchymal transition via downregulating expressions of snail, slug, and twist

2020 ◽  
Vol 121 (5-6) ◽  
pp. 3313-3324 ◽  
Author(s):  
Eda Acikgoz ◽  
Cansu Tatar ◽  
Gulperi Oktem
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cell Growth ◽  
Cancer Stem Cell ◽  
Epithelial Mesenchymal Transition ◽  
Cell Growth And Migration ◽  
Mesenchymal Transition ◽  
Colon Cancer Stem Cell ◽  
And Migration

Abstract 1007: Honokiol inhibits colon cancer stem cell growth and mechanism mediated through Notch signaling pathway

2012 ◽  
Author(s):  
Dharmalingam Subramaniam ◽  
Sivapriya Ponnurangam ◽  
Satish Ramalingam ◽  
Zhiyun He ◽  
Youcheng Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cell Growth ◽  
Cancer Stem Cell ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
Colon Cancer Stem Cell

scholarly journals Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts

2013 ◽  
Vol 30 (4) ◽  
pp. 1782-1792 ◽  
Author(s):  
YINGYING ZHAO ◽  
WENJING ZHANG ◽  
ZHENG GUO ◽  
FENG MA ◽  
YAO WU ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Transcription Factor ◽  
Stem Cell ◽  
Cell Growth ◽  
Cancer Stem Cell ◽  
Nude Mouse ◽  
Colon Cancer Stem Cell ◽  
Transcription Factor Sp1

Enhanced LINC01061 Levels as a Serum Biomarker in Gastric Cancer and Promotion of Malignant Transformation

2021 ◽  
Vol 44 (5) ◽  
pp. 242-251
Author(s):  
Wei Liang ◽  
Bin Xia ◽  
Meina Yan ◽  
Guanghua Zhai ◽  
Meifen Li
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Epithelial Mesenchymal Transition ◽  
Growth Curves ◽  
Functional Study ◽  
Cell Growth And Migration ◽  
Mesenchymal Transition ◽  
Qrt Pcr ◽  
And Migration

<b><i>Background:</i></b> The genomic copy number of LINC01061 is amplified in papillary thyroid cancer. However, its role in gastric cancer is not clear. <b><i>Materials and Methods:</i></b> Tissues and serum of GC patients were collected to detect the expression of LINC01061 by quantitative real-time polymerase chain reaction (qRT-PCR). ShRNA were applied to knock down the expression of LINC01061. Growth curves and colony formation experiments were applied to evaluate cell growth. Cell migration was assessed by transwell migration experiments. Cell cycle and apoptosis were analyzed by flow cytometry. Epithelial-mesenchymal transition (EMT) was examined by qRT-PCR and Western blot. <b><i>Results:</i></b> The expression of LINC01061 was upregulated in tissues and serum of GC patients and it was associated with the clinicopathological features and survival time. Functional study indicated that cell growth and migration were suppressed after LINC01061 knockdown. Cell cycle arrest and increased apoptosis occurred when LINC01061 expression was inhibited. EMT was also impaired combined with a decrease in β-catenin expression after LINC01061 knockdown. <b><i>Conclusions:</i></b> Our data indicate that LINC01061 is a novel biomarker for diagnosis and prognosis of GC. LINC01061 promoted progression of GC through cell cycle regulation and EMT.

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