The stimulation of tumor cell growth by a substance produced by normal and tumor cells

1969 ◽  
Vol 73 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Yasuo Ichikawa ◽  
Michael Paran ◽  
Leo Sachs
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Tumor Cell Growth ◽  
Stimulation Of

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth

2014 ◽  
Vol 29 (1) ◽  
pp. 274-285 ◽  
Author(s):  
Jess Morhayim ◽  
Jeroen Peppel ◽  
Jeroen A. A. Demmers ◽  
Gulistan Kocer ◽  
Alex L. Nigg ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Extracellular Vesicles ◽  
Tumor Cell Growth ◽  
Human Osteoblasts ◽  
Stimulation Of

scholarly journals Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways

Cancers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 229
Author(s):  
Xue Zhao ◽  
Shinichi Sakamoto ◽  
Maihulan Maimaiti ◽  
Naohiko Anzai ◽  
Tomohiko Ichikawa
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Essential Amino Acids ◽  
Amino Acid Transporter ◽  
Tumor Cell Growth ◽  
Transporter Protein ◽  
Urological Cancers

Tumor cells are known for their ability to proliferate. Nutrients are essential for rapidly growing tumor cells. In particular, essential amino acids are essential for tumor cell growth. Tumor cell growth nutrition requires the regulation of membrane transport proteins. Nutritional processes require amino acid uptake across the cell membrane. Leucine, one of the essential amino acids, has recently been found to be closely associated with cancer, which activate mTOR signaling pathway. The transport of leucine into cells requires an L-type amino acid transporter protein 1, LAT1 (SLC7A5), which requires the 4F2 cell surface antigen heavy chain (4F2hc, SLC3A2) to form a heterodimeric amino acid transporter protein complex. Recent evidence identified 4F2hc as a specific downstream target of the androgen receptor splice variant 7 (AR-V7). We stressed the importance of the LAT1-4F2hc complex as a diagnostic and therapeutic target in urological cancers in this review, which covered the recent achievements in research on the involvement of the LAT1-4F2hc complex in urinary system tumors. In addition, JPH203, which is a selective LAT1 inhibitor, has shown excellent inhibitory effects on the proliferation in a variety of tumor cells. The current phase I clinical trials of JPH203 in patients with biliary tract cancer have also achieved good results, which is the future research direction for LAT1 targeted therapy drugs.

scholarly journals Mathematical Modelling of the Dynamics of Tumor Growth and its Optimal Control

2020 ◽  
Author(s):  
Jannatun Irana Ira ◽  
Md. Shahidul Islam ◽  
Jagadish Chandra Misra
Keyword(s):  
Optimal Control ◽  
Cell Growth ◽  
Tumor Growth ◽  
Mathematical Modelling ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Treatment Process ◽  
Tumor Cell Growth ◽  
Growth Of Tumor ◽  
Over Time

The dynamics of tumor cell growth and its treatment process is discussed in this paper. We analyze some simple mathematical models and generalized models to understand the growth of tumor cells. A couple of diffusion models are discussed to explain how the tumor cells spread and become more dangerous as well as the treatment process of cancer and how cancer cell behaves in the presence of different therapy and drugs. The optimal control of chemotherapy has been discussed. It has also been explained how much the model is effective in reducing tumor cells over time.

Lung Laminin-332 Deficiency Enhances Engraftment of Tumor Cells into the Lung but Retards Tumor Cell Growth

2012 ◽  
Vol 9 (2) ◽  
pp. 83-83
Author(s):  
Tracy L. Adair-Kirk ◽  
Michelle J. Meyer ◽  
Haris G. Vikas ◽  
Jay W. Tichelaar ◽  
Erin N. Jackson ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Tumor Cell Growth ◽  
Laminin 332
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