scholarly journals Computed tomography‐defined body composition as prognostic markers for unfavourable outcomes and in‐hospital mortality in coronavirus disease 2019

Author(s):  
Hans‐Jonas Meyer ◽  
Andreas Wienke ◽  
Alexey Surov
2021 ◽  
Vol 1 ◽  
pp. 100115
Author(s):  
Olivier Groot ◽  
Neal Kapoor ◽  
Colleen Buckless ◽  
peter Twining ◽  
Michiel Bongers ◽  
...  

2021 ◽  
Author(s):  
Ludmila Koch ◽  
Andrea Z Pereira ◽  
Nelson Hamerschlak ◽  
Adham do Amaral e Castro ◽  
Adriano Tachibana ◽  
...  

Abstract Aim: The incidence of most hematologic malignancies increases with age. Hematopoietic stem cell transplantation (HSCT) provides a potentially life-prolonging or curative option for many patients in this scenario. Limited data is available on muscle mass and density assessed from CT-images on outcomes after HSCT. We aimed to evaluate the influence of body composition on morbidity and mortality in older adults undergoing (HSCT). Methods: Retrospective longitudinal study conducted with 50 patients ≥ 60 years undergoing HSCT at Hospital Israelita Albert Einstein, São Paulo. Body composition was assessed by chest computed tomography and treatment related mortality, graft versus host disease, neutrophil grafting, and overall survival were analyzed.Results: 148 HSCT patients were evaluated, 50 patients were eligible: 60% with autologous and 40% with allogeneic transplantation. Body mass index in patients was (female: 26.9 ± 4.7 kg/m2; 30.1± 4.9 kg/m2) - autologous and (female: 24.3 ± 5.15 kg/m2; male: 26.4 ± 2.0 kg/m2) - allogeneic. In autologous transplant group, we found a positive association between age and death risk with an increase of 63.5% in this risk (p=0.006) and also Karnofsky performance scale with decrease of 11.9% in death risk (p<0.001). A negative association between muscle radiodensity and death risk was observed in allogeneic transplantation patients with risk decrease of 20.1% (p = 0.032). We found a positive association between T4 muscle area and radiodensity with risk of acute graft versus host disease (p= 0.028). Conclusion: In population studied, body composition assessed by chest tomography showed the importance of radiodensity for better prognosis.


2016 ◽  
Vol 35 ◽  
pp. S16
Author(s):  
K.E. Rollins ◽  
H. Javanmard-Emamghissi ◽  
A. Awwad ◽  
I.A. Macdonald ◽  
K.C. Fearon ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Young Seo Cho ◽  
Ha Young Lee ◽  
Jae Yoon Jeong ◽  
Jae Gon Lee ◽  
Tae Yeob Kim ◽  
...  

2019 ◽  
Vol 61 (1) ◽  
pp. 136-144
Author(s):  
Tetsuhiro Otsuka ◽  
Eijun Sueyoshi ◽  
Yutaro Tasaki ◽  
Masataka Uetani

Background The relationships between the computed tomography (CT) findings and outcomes of patients with ruptured type B aortic dissection have not been clarified. Purpose To evaluate the initial CT findings of patients with ruptured type B aortic dissection and investigate the relationships between the initial CT findings and in-hospital mortality. Material and Methods This study was approved by the institutional review board. Thirty-three patients were diagnosed with ruptured Stanford type B aortic dissection at our hospital between 2007 and 2016 (21 men, 12 women; mean age = 76.1±10.7 years). We retrospectively evaluated the initial CT findings of ruptured type B aortic dissection and the relationships between clinical factors and in-hospital mortality using logistic regression analysis. Results Type B aortic dissections ruptured in the acute and chronic phases in 23 and 10 patients, respectively. The initial CT images showed various findings, including an open false lumen (58%), arch involvement (88%), hematomas in the pleural space (55%), hematomas in the pericardial space (18%), and the extravasation of vascular contrast material (12%). The mean maximum diameter of the affected aorta was 49.5 ± 16.1 mm. Among the 33 patients, 14 died at hospital. Female gender (hazard ratio = 10.284; 95% confidence interval [CI] = 1.61–65.54; P = 0.0136) and the presence of a hematoma in the pleural space (hazard ratio = 6.803; 95% CI = 1.07–43.24; P = 0.0421) were found to be predictors of in-hospital mortality. Conclusion Female gender and the presence of a hematoma in the pleural space are significant predictors of in-hospital mortality in patients with ruptured type B aortic dissection.


Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1864
Author(s):  
Jongsoo Lee ◽  
Jee Soo Park ◽  
Ji Eun Heo ◽  
Hyun Kyu Ahn ◽  
Won Sik Jang ◽  
...  

Limited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on castration-resistant prostate cancer (CRPC) outcomes. Skeletal muscle index (SMI) and skeletal muscle attenuation (SMA) were measured for 411 patients at the L3 vertebral level using computed tomography at CRPC diagnosis and were dived to low and high groups at the value of median. Analysis of the skeletal phenotypes and age (<70 and >70 years) was performed to evaluate the effect of SMI and SMA. The median survival rates for patients with low and high SMI were 19 and 24 months (p = 0.015), and those with low and high SMAs were 15 and 26 months (p < 0.001), respectively. In the subgroup analysis by age, SMA was a significant prognosticator in both groups, while SMI was a significant prognosticator only in patients aged >70 years. Patients with low SMA + low SMI had the worst prognosis. Muscle characteristics seems to be a prognosticator in survival of CRPC patients and may be considered in treatment planning.


2020 ◽  
Vol 33 (12) ◽  
pp. 1610-1625
Author(s):  
Dmitry Rozenberg ◽  
Camila E. Orsso ◽  
Karan Chohan ◽  
Ani Orchanian‐Cheff ◽  
Sahar Nourouzpour ◽  
...  

2018 ◽  
Vol 97 (11) ◽  
pp. 4093-4106 ◽  
Author(s):  
Marine F Dewez ◽  
Patrice Etourneau ◽  
François Lecompte ◽  
Sylvain Briere ◽  
Pascal Froment

Nutrition ◽  
2019 ◽  
Vol 59 ◽  
pp. 50-55 ◽  
Author(s):  
Fabian Morsbach ◽  
Yi-Hua Zhang ◽  
Lena Martin ◽  
Catarina Lindqvist ◽  
Torkel Brismar

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