scholarly journals Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion

2021 ◽  
Vol 10 (11) ◽  
Author(s):  
Lei Xi ◽  
Meixi Peng ◽  
Shuiqing Liu ◽  
Yongcan Liu ◽  
Xueying Wan ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts

2015 ◽  
Vol 142 (2) ◽  
pp. 437-446 ◽  
Author(s):  
Shinya Neri ◽  
Hiroko Hashimoto ◽  
Hiroaki Kii ◽  
Hirotada Watanabe ◽  
Kenkichi Masutomi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

scholarly journals Cancer-Associated Fibroblasts Differentiated by Exosomes Isolated from Cancer Cells Promote Cancer Cell Invasion

2020 ◽  
Vol 21 (21) ◽  
pp. 8153
Author(s):  
Kimin Kim ◽  
Yeh Joo Sohn ◽  
Ruri Lee ◽  
Hye Ju Yoo ◽  
Ji Yoon Kang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cell Types ◽  
Cancer Drug ◽  
Cancer Microenvironment ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

Cancer-associated fibroblasts (CAFs) in the cancer microenvironment play an essential role in metastasis. Differentiation of endothelial cells into CAFs is induced by cancer cell-derived exosomes secreted from cancer cells that transfer molecular signals to surrounding cells. Differentiated CAFs facilitate migration of cancer cells to different regions through promoting extracellular matrix (ECM) modifications. However, in vitro models in which endothelial cells exposed to cancer cell-derived exosomes secreted from various cancer cell types differentiate into CAFs or a microenvironmentally controlled model for investigating cancer cell invasion by CAFs have not yet been studied. In this study, we propose a three-dimensional in vitro cancer cell invasion model for real-time monitoring of the process of forming a cancer invasion site through CAFs induced by exosomes isolated from three types of cancer cell lines. The invasiveness of cancer cells with CAFs induced by cancer cell-derived exosomes (eCAFs) was significantly higher than that of CAFs induced by cancer cells (cCAFs) through physiological and genetic manner. In addition, different genetic tendencies of the invasion process were observed in the process of invading cancer cells according to CAFs. Our 3D microfluidic platform helps to identify specific interactions among multiple factors within the cancer microenvironment and provides a model for cancer drug development.

scholarly journals IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling

2014 ◽  
Vol 111 (4) ◽  
pp. 763-771 ◽  
Author(s):  
H Fukui ◽  
X Zhang ◽  
C Sun ◽  
K Hara ◽  
S Kikuchi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Gastric Cancer Cell ◽  
Erk Signaling ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

scholarly journals Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Yinghui Ren ◽  
Limin Cao ◽  
Limin Wang ◽  
Sijia Zheng ◽  
Qicheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung

AbstractTumor progression requires the communication between tumor cells and tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are major components of stromal cells. CAFs contribute to metastasis process through direct or indirect interaction with tumor cells; however, the underlying mechanism is largely unknown. Here, we reported that autophagy was upregulated in lung cancer-associated CAFs compared to normal fibroblasts (NFs), and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer (NSCLC) cell migration and invasion. Inhibition of CAFs autophagy attenuated their regulation on epithelial–mesenchymal transition (EMT) and metastasis-related genes of NSCLC cells. High mobility group box 1 (HMGB1) secreted by CAFs mediated CAFs’ effect on lung cancer cell invasion, demonstrated by using recombinant HMGB1, HMGB1 neutralizing antibody, and HMGB1 inhibitor glycyrrhizin (GA). Importantly, the autophagy blockade of CAFs revealed that HMGB1 release was dependent on autophagy. We also found HMGB1 was responsible, at least in part, for autophagy activation of CAFs, suggesting CAFs remain active through an autocrine HMGB1 loop. Further study demonstrated that HMGB1 facilitated lung cancer cell invasion by activating the NFκB pathway. In a mouse xenograft model, the autophagy specific inhibitor chloroquine abolished the stimulating effect of CAFs on tumor growth. These results elucidated an oncogenic function for secretory autophagy in lung cancer-associated CAFs that promotes metastasis potential, and suggested HMGB1 as a novel therapeutic target.

Loss of exosomal miR‐148b from cancer‐associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis

2018 ◽  
Vol 234 (3) ◽  
pp. 2943-2953 ◽  
Author(s):  
Bi‐Lan Li ◽  
Wen Lu ◽  
Jun‐Jie Qu ◽  
Lei Ye ◽  
Gui‐Qiang Du ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Metastasis ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion ◽  
Endometrial Cancer Cell

Abstract 185: Cancer associated fibroblasts stimulates cancer cell invasion through CXCL12-CXCR4 signaling in gastric cancer

2014 ◽  
Author(s):  
Daisuke Izumi ◽  
Takatsugu Ishimoto ◽  
Hietaka Sugihara ◽  
Hiroshi Sawayama ◽  
Ryuichi Karashima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion ◽  
Cxcr4 Signaling

scholarly journals Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Alexandros Glentis ◽  
Philipp Oertle ◽  
Pascale Mariani ◽  
Aleksandra Chikina ◽  
Fatima El Marjou ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

scholarly journals P3.01-001 Cancer Cell Invasion Driven by Extracellular Matrix Remodeling is Dependent on the Properties of Cancer-Associated Fibroblasts

2017 ◽  
Vol 12 (1) ◽  
pp. S1119
Author(s):  
Shinya Neri ◽  
Hiroshi Date ◽  
Masahiro Tsuboi ◽  
Koichi Goto ◽  
Atsushi Ochiai ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion
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