Interfacial activity and micellar morphology of an imidazolium ring containing zwitterionic surfactants

2022 ◽  
Author(s):  
Hazrat Ali ◽  
Azim Khan ◽  
Tauqeer Ahmad ◽  
Athanasia Dervisi ◽  
Ian Fallis ◽  
...  
Keyword(s):  
Interfacial Activity ◽  
Zwitterionic Surfactants ◽  
Imidazolium Ring ◽  
Micellar Morphology

The Impact of Bioconjugation on the Interfacial Activity of a Protein Biosurfactant

2018 ◽  
Author(s):  
Hossam H Tayeb ◽  
Marina Stienecker ◽  
Anton Middelberg ◽  
Frank Sainsbury
Keyword(s):  
Polyethylene Glycol ◽  
Colloidal Stability ◽  
Point Mutations ◽  
Pharmaceutical Formulations ◽  
Industrial Processes ◽  
Parent Molecule ◽  
Site Specific ◽  
Interfacial Activity ◽  
Surface Active ◽  
The Impact

Biosurfactants, are surface active molecules that can be produced by renewable, industrially scalable biologic processes. DAMP4, a designer biosurfactant, enables the modification of interfaces via genetic or chemical fusion to functional moieties. However, bioconjugation of addressable amines introduces heterogeneity that limits the precision of functionalization as well as the resolution of interfacial characterization. Here we designed DAMP4 variants with cysteine point mutations to allow for site-specific bioconjugation. The DAMP4 variants were shown to retain the structural stability and interfacial activity characteristic of the parent molecule, while permitting efficient and specific conjugation of polyethylene glycol (PEG). PEGylation results in a considerable reduction on the interfacial activity of both single and double mutants. Comparison of conjugates with one or two conjugation sites shows that both the number of conjugates as well as the mass of conjugated material impacts the interfacial activity of DAMP4. As a result, the ability of DAMP4 variants with multiple PEG conjugates to impart colloidal stability on peptide-stabilized emulsions is reduced. We suggest that this is due to constraints on the structure of amphiphilic helices at the interface. Specific and efficient bioconjugation permits the exploration and investigation of the interfacial properties of designer protein biosurfactants with molecular precision. Our findings should therefore inform the design and modification of biosurfactants for their increasing use in industrial processes, and nutritional and pharmaceutical formulations.

Effect of Molecular Structure on Interfacial Activity and Emulsification Property

2012 ◽  
Vol 49 (5) ◽  
pp. 394-397 ◽  
Author(s):  
Lifeng Chen ◽  
Xiutai Zhao ◽  
Zengbao Wang ◽  
Yingrui Bai
Keyword(s):  
Molecular Structure ◽  
Interfacial Activity ◽  
Emulsification Property

Kinetics of the Imidazolium Ring-Opening of mRNA 5'-cap Analogs in Aqueous Alkali

2006 ◽  
Vol 71 (4) ◽  
pp. 567-578 ◽  
Author(s):  
Alicja Stachelska ◽  
Zbigniew J. Wieczorek ◽  
Janusz Stępiński ◽  
Marzena Jankowska-Anyszka ◽  
Harri Lönnberg ◽  
...  
Keyword(s):  
Electrostatic Interaction ◽  
Ring Opening ◽  
Nucleophilic Attack ◽  
Amino Groups ◽  
Hydroxide Ion ◽  
Methyl Group ◽  
Structural Modifications ◽  
Alkyl Groups ◽  
Imidazolium Ring ◽  
Kinetics Of

Second-order rate constants for the hydroxide-ion-catalyzed imidazolium ring-opening of several mono- and dinucleosidic analogs of mRNA 5'-cap have been determined. Intramolecular stacking of the two nucleobases in the dinucleosidic analogs, m7GpppN (m7G = 7-methylguanosine, N = 5'-linked nucleoside), and electrostatic interaction between the N-alkylated imidazolium ring and phosphate moiety have been shown to shield the m7G moiety against the nucleophilic attack of hydroxide ion. In addition, the effect of methylation of the nucleobase amino groups and replacement of the 7-methyl group with other alkyl groups have been studied. The influence of all the structural modifications studied turned out to be modest, the cleavage rates of the most and least reactive analogs (with the exception of non-phosphorylated nucleosides) differing only by a factor of 5.

Microfabrication Enables Quantification of Interfacial Activity in Thermal Catalysis

Small Methods ◽  
2021 ◽  
pp. 2001231
Author(s):  
Matthias S. Frei ◽  
Florentine L. P. Veenstra ◽  
David Capeder ◽  
Joseph A. Stewart ◽  
Daniel Curulla‐Ferré ◽  
...  
Keyword(s):  
Interfacial Activity

Cyclization of PEG and Pluronic Surfactants and the Effects of the Topology on Their Interfacial Activity

Langmuir ◽  
2021 ◽  
Author(s):  
Tomohisa Watanabe ◽  
Satoru Chimura ◽  
Yubo Wang ◽  
Tomoko Ono ◽  
Takuya Isono ◽  
...  
Keyword(s):  
Interfacial Activity

Synthesis and Interfacial Activity of Alkyl Polyoxypropylene Sulfonate for Chemical Combination Flooding

2012 ◽  
Vol 550-553 ◽  
pp. 3-9
Author(s):  
You Yi Zhu ◽  
Zhang Lei Ning ◽  
Qing Feng Hou ◽  
Ming Lei ◽  
Guo Qing Jian
Keyword(s):  
Salt Tolerance ◽  
Interfacial Tension ◽  
Divalent Cation ◽  
Carbon Chain ◽  
Carbon Chain Length ◽  
Formation Water ◽  
Interfacial Activity ◽  
Chemical Combination ◽  
Ultralow Interfacial Tension ◽  
Oil Formation

A serious of alkyl polyoxypropylene sulfonate surfactant was synthesized. The O/W interfacial activity of alkyl polyoxypropylene sulfonate surfactant was investigated. The results showed that the interfacial tension of Indonesia crude oil/formation water could reach ultralow level (10-3mN/m order of the magnitude) under weak alkali (Na2CO3) concentration from 0.4wt% to 1.0wt% with C16PO8S, C16PO10S, C18PO8S and C18PO10S alkyl polyoxypropylene sulfonate respectively. These surfactants showed good interface activity and salt and divalent cation tolerance ability. Combinations of alkyl polyoxypropylene sulfanate homologies with different carbon chain length could significantly improve the interface activity. The IFT of Indonesia oil/formation water could reach ultralow interfacial tension under alkali free conditions. The combination of alkyl polyoxypropylene sulfonate surfactant with petroleum sulfonate could improve the salt tolerance ability of formula.

scholarly journals Controlling the micellar morphology of binary PEO–PCL block copolymers in water–THF through controlled blending

Soft Matter ◽  
2011 ◽  
Vol 7 (2) ◽  
pp. 749-759 ◽  
Author(s):  
Peter Schuetz ◽  
Martin J. Greenall ◽  
Julian Bent ◽  
Steve Furzeland ◽  
Derek Atkins ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Micellar Morphology
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