Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system

2017 ◽  
Vol 116 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Laura Lorenzon ◽  
Claudia Cippitelli ◽  
Riccardo Avantifiori ◽  
Stefania Uccini ◽  
Deborah French ◽  
...  
Keyword(s):  
Classification System ◽  
Gastric Cancers ◽  
Lauren's Classification ◽  
Lauren’S Classification

Effect of a mixed type Lauren's classification on agressiveness and lymph node metastasis in early gastric cancer.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 28-28
Author(s):  
Jeunghui Pyo ◽  
Hyuk Lee ◽  
In Seub Shin ◽  
Tae Jun Kim ◽  
Yang Won Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Mixed Type ◽  
Clinicopathological Features ◽  
Node Metastasis ◽  
Lauren's Classification ◽  
Lauren’S Classification

28 Background: The clinicopathological features of mixed type (MT) early gastric cancer (EGC) according to Lauren’s classification remain uninvestigated. This study aimed to clarify the clinicopathological features of MT EGC, particularly in relation to lymph node metastasis (LNM) and long-term survival. Methods: This study included 5,309 patients who underwent gastrectomy for EGC. The clinicopathological features, LNM, and long-term outcomes of patients with MT carcinomas were compared to those with intestinal type (IT) and diffuse type (DT) cancers. Furthermore, we evaluated the predictors of LNM in each Lauren classification subgroup. Results: Patients with MT carcinomas were more likely to have larger tumors, submucosal invasion, lymphovascular invasion (LVI), and LNM compared to those with IT or DT carcinomas. Multivariate logistic regression analysis revealed that Lauren’s classification was a significant predictor of LNM ( P < 0.001). The significant predictors of LNM in MT carcinomas were female sex, greater tumor size, presence of submucosal invasion, and LVI. However, the overall survival of patients with MT carcinoma was not significantly different from that of patients with IT or DT carcinomas ( P= 0.104). Conclusions: The presence of MT EGC carries a higher risk of LNM compared to IT or DT carcinomas. Therefore, MT carcinomas should be managed with gastrectomy that includes lymph node dissection instead of endoscopic resection.

Comparisons between intestinal and diffuse gastric cancer in response to apatinib: Data from post-marketing phase IV study.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 36-36
Author(s):  
Guifang Zhang ◽  
Shukui Qin ◽  
Jin Li ◽  
Wenying Deng ◽  
Lu Wen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Clinical Benefit ◽  
Small Sample ◽  
Histological Type ◽  
Diffuse Gastric Cancer ◽  
Lauren's Classification ◽  
Post Marketing ◽  
Lauren’S Classification ◽  
Phase Iv

36 Background: Intestinal and diffuse gastric cancer are main histological types of gastric cancer, based on Lauren’s classification, which account for 34–47% and 46–57%, respectively. Patients (pts) with intestinal gastric cancer have better prognosis. The present study aimed to compare the safety and efficacy of apatinib between the two intestinal gastric cancer, based on data from post-marketing Phase IV study (Ahead-G201). Methods: The single-arm, open-label, multi-center, Phase IV trial enrolled advanced or metastatic adenocarcinoma of stomach or gastroesophageal junction after failure of ≥2 lines of chemotherapy. Data of pts with intestinal and diffuse gastric cancer were collected and compared. Results: As of 2017/7/10, 96 intestinal and 104 diffuse pts were recruited. Differences in age (64 vs. 55 yrs), gender (male: 77.1% vs. 57.7%) and disease duration ( > 12 months: 71.3% vs. 56.7%) were detected. Between intestinal and diffuse gastric cancer, there was no discrepancy in incidences of adverse events (AEs) (78.1% vs. 73.1%) and Grade ≥3 AEs (41.7% vs. 38.5%). The incidences of typical AEs associated anti-angiogenesis drugs were also comparable (hypertension 26.0% vs. 16.4%; proteinuria 14.6% vs. 20.2%; hand-foot-skin reaction 16.7% vs. 9.6%). No statistical difference was observed in best overall response rate (12.8% vs. 14.3%) and disease control rate (76.0% vs. 64.3%). Survival benefit in pts with intestinal gastric cancer was detected (progression free survival: 5.52 vs. 2.76 months, p = 0.036; overall survival: 8.11 vs. 4.70 months, p = 0.047). However, the multivariable Cox regression model analysis showed that histological type was not independently prognostic factors for survival, indicating that clinical benefit of pts with intestinal gastric cancer was influenced by other factors. Conclusions: Compared with diffuse gastric cancer, pts intestinal gastric cancer have more clinical benefit after treated by apatinib. However, histological type based on the Lauren’s classification was not independently prognostic factors for survival, which needs to be further analyzed, considering the small sample size. Clinical trial information: NCT02426034.

Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren’s Classification

2016 ◽  
Vol 23 (S5) ◽  
pp. 784-791 ◽  
Author(s):  
Jeung Hui Pyo ◽  
Soomin Ahn ◽  
Hyuk Lee ◽  
Byung-Hoon Min ◽  
Jun Haeng Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mixed Type ◽  
Clinicopathological Features ◽  
Lauren's Classification ◽  
Lauren’S Classification

scholarly journals Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

2006 ◽  
Vol 43 (4) ◽  
pp. 288-292 ◽  
Author(s):  
Irami Araújo-Filho ◽  
José Brandão-Neto ◽  
Laíza Araújo Mohana Pinheiro ◽  
Ítalo Medeiros Azevedo ◽  
Flávio Henrique Miranda Araújo Freire ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Tumor Tissue ◽  
Intestinal Type ◽  
Gastric Carcinomas ◽  
Tumor Tissues ◽  
Lauren's Classification ◽  
Lauren’S Classification ◽  
H Pylori

BACKGROUD: There is substantial evidence that infection with Helicobacter pylori plays a role in the development of gastric cancer and that it is rarely found in gastric biopsy of atrophic gastritis and gastric cancer. On advanced gastric tumors, the bacteria can be lost from the stomach. AIMS: To analyze the hypothesis that the prevalence of H.pylori in operated advanced gastric carcinomas and adjacent non-tumor tissues is high, comparing intestinal and diffuse tumors according to Lauren's classification METHODS: A prospective controlled study enrolled 56 patients from "Hospital Universitário", Federal University of Rio Grande do Norte, Natal, RN, Brazil, with advanced gastric cancer, treated from February 2000 to March 2003. Immediately after partial gastrectomy, the resected stomach was opened and several mucosal biopsy samples were taken from the gastric tumor and from the adjacent mucosa within 4 cm distance from the tumor margin. Tissue sections were stained with hematoxylin and eosin. Lauren's classification for gastric cancer was used, to analyse the prevalence of H. pylori in intestinal or diffuse carcinomas assessed by the urease rapid test, IgG by ELISA and Giemsa staining. H. pylori infected patients were treated with omeprazole, clarithromycin and amoxicillin for 7 days. Follow-up endoscopy and serology were performed 6 months after treatment to determine successful eradication of H. pylori in non-tumor tissue. Thereafter, follow-up endoscopies were scheduled annually. Chi-square and MacNemar tests with 0.05 significance were used. RESULTS: Thirty-four tumors (60.7%) were intestinal-type and 22 (39.3%) diffuse type carcinomas. In adjacent non-tumor gastric mucosa, chronic gastritis were found in 53 cases (94.6%) and atrophic mucosa in 36 patients (64.3%). All the patients with atrophic mucosa were H. pylori positive. When examined by Giemsa and urease test, H. pylori positive rate in tumor tissue of intestinal type carcinomas was higher than that in diffuse carcinomas. In tumor tissues, 34 (60.7%) H. pylori-positive in gastric carcinomas were detected by Giemsa method. H. pylori was observed in 30 of 56 cases (53.5%) in tissues 4 cm adjacent to tumors. This difference was not significant. Eradication of H. pylori in non-tumor tissue of gastric remnant led to a complete negativity on the 12th postoperative month CONCLUSIONS: The data confirmed the hypothesis of a high prevalence of H. pylori in tumor tissue of gastric advanced carcinomas and in adjacent non-tumor mucosa of operated stomachs. The presence of H. pylori was predominant in the intestinal-type carcinoma.

Evaluation of the feasibility of expression microarray analysis in endoscopically obtained biopsies of gastric carcinoma and their clinical applicability

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21164-21164
Author(s):  
M. P. Jhawer ◽  
L. Qin ◽  
H. Gerdes ◽  
D. Klimstra ◽  
M. Schattner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Microarray Analysis ◽  
Expression Analysis ◽  
Expression Profiles ◽  
Endoscopic Biopsy ◽  
Expression Microarray ◽  
Lauren's Classification ◽  
Lauren’S Classification

21164 Background: The feasibility of extracting high quality RNA for expression microarray analysis from endoscopic biopsy in gastric carcinoma has not been previously established. Methods: Patients with histologically confirmed locally advanced gastric or gastroesophageal junction adenocarcinoma were screened for enrollment in an NCI-sponsored trial of neoadjuvant irinotecan and cisplatin chemotherapy (NC1–5917). All patients underwent a repeat endoscopic biopsy for the procurement of fresh tumor tissue. Gross microdissection was performed to enrich the sample to at least 80% malignancy. RNA was isolated from the tumor specimens using RNeasy columns (Qiagen) and its quality verified by RNA 6000 NanoAssay and Bioanalyzer 2100 (Agilent). Gene expression profiling was performed on Human Genome U133A GeneChip (Affymetrix) which contained 22,215 oligonucleotide-base probe-sets. Differential gene expression profiles for Lauren's classification were assessed using empirical Bayes t test, a threshold p < 0.001 was considered statistically significant. Results: Of 36 patients with previous biopsy confirmed gastric cancer, repeat endoscopic biopsy identified carcinoma in 28 patients (78%, 95%CI 61–90%). Adequate RNA for microarray analysis was obtained from 21 patients-representing 58% of those who presented for the procedure and 75% in whom endoscopic biopsies confirmed malignancy. This yield improved with increasing number of samples taken. Lauren's classification was available on 26 patients who underwent resection. From the total 54,613 gene probe-sets on the arrays, comparison of the expression profiles of diffuse-type and intestinal-type identified 167 genes that were differentially expressed. Diffuse gastric cancer demonstrated altered expression of genes related to cell-matrix interaction whereas intestinal gastric cancer expression analysis showed enhancement of cell growth. Conclusions: Endoscopic biopsy for expression analysis of gastric cancer is feasible with increasing yield with each core taken. Expression analysis at the time of endoscopic biopsy can differentiate Lauren's histology, a characteristic not routinely evaluable by pathologic review. No significant financial relationships to disclose.

scholarly journals Significance of Lauren's Classification in Chemotherapy of Gastric Carcinoma

1976 ◽  
Vol 119 (1) ◽  
pp. 41-49 ◽  
Author(s):  
GORO KAKIZAKI ◽  
YOSHIYUKI FUJIWARA ◽  
EIICHI KATO ◽  
TAKAYUKI SAITO ◽  
TOYOKICHI MAETA ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Lauren's Classification ◽  
Lauren’S Classification

Gastric cancer in a high-risk area in italy: Histopathologic patterns according to Lauren's classification

Cancer ◽  
1988 ◽  
Vol 62 (10) ◽  
pp. 2191-2196 ◽  
Author(s):  
Andrea Amorosi ◽  
Simonetta Bianchi ◽  
Eva Bulatti ◽  
Francesco Cipriani ◽  
Domenico Palli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Risk Area ◽  
High Risk Area ◽  
Lauren's Classification ◽  
Lauren’S Classification

International Research and Variation in Views of Ethnicity

2012 ◽  
Vol 2 (2) ◽  
pp. 66-72
Author(s):  
Ella Inglebret ◽  
Amy Skinder-Meredith ◽  
Shana Bailey ◽  
Carla Jones ◽  
Ashley France
Keyword(s):  
United States ◽  
Classification System ◽  
International Research ◽  
The United States ◽  
Research Articles ◽  
Journal Articles ◽  
Research Participants ◽  
The Past ◽  
International Scale ◽  
Publication Patterns

The authors in this article first identify the extent to which research articles published in three American Speech-Language-Hearing Association (ASHA) journals included participants, age birth to 18 years, from international backgrounds (i.e., residence outside of the United States), and go on to describe associated publication patterns over the past 12 years. These patterns then provide a context for examining variation in the conceptualization of ethnicity on an international scale. Further, the authors examine terminology and categories used by 11 countries where research participants resided. Each country uses a unique classification system. Thus, it can be expected that descriptions of the ethnic characteristics of international participants involved in research published in ASHA journal articles will widely vary.

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