scholarly journals Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma

2021 ◽  
Author(s):  
Hui‐Ting Liu ◽  
Tian Xia ◽  
Yi‐Wen You ◽  
Qi‐Cheng Zhang ◽  
Hao‐sheng Ni ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Clinical Significance ◽  
Laryngeal Carcinoma ◽  
Polyploid Giant Cancer Cells

Tu1920 Distinct Subcellular Localization of Phosphorylated ErbB2, ErbB3 and ErbB4 in Colorectal Cancer Cells and Their Relevance to Clinical Significance

2013 ◽  
Vol 144 (5) ◽  
pp. S-881
Author(s):  
Atsushi Tatsuguchi ◽  
Keigo Mitsui ◽  
Masaoki Yonezawa ◽  
Shu Tanaka ◽  
Shunji Fujimori ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Subcellular Localization ◽  
Cancer Cells ◽  
Clinical Significance ◽  
Colorectal Cancer Cells

scholarly journals PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Hongmin Gao ◽  
Juan Zhang ◽  
Xiaohong Ren
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
Cancer Cells ◽  
Clinical Significance ◽  
Tumour Cell ◽  
Normal Tissue ◽  
Ovarian Tumour ◽  
Ovarian Cancer Cells ◽  
Adjacent Normal Tissue ◽  
Novel Strategy

Abstract PD-L1 is a well-known immune co-stimulatory molecule that regulates tumour cell escape from immunity by suppressing the immune response. However, the clinical significance of PD-L1 in the progression of ovarian cancer is unclear. Our study demonstrated that PD-L1 is up-regulated in ovarian tumour tissue compared with its expression level in adjacent normal tissue. Furthermore, we confirmed that PD-L1 increases the proliferation of cancer cells by activating the AKT-mTORC signalling pathway, which is also enhanced by the expression of S6K, the substrate of mTORC. In addition, PD-L1 promotes the autophagy of ovarian cancer cells by up-regulating the expression of BECN1, a crucial molecule involved in the regulation of autophagy. In conclusion, PD-L1 may provide a target for the development of a novel strategy for the treatment of ovarian cancer.

Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance

2017 ◽  
pp. 45-59 ◽  
Author(s):  
Takahiko Kawate ◽  
Benio Tsuchiya ◽  
Keiichi Iwaya
Keyword(s):  
Cancer Cells ◽  
Clinical Significance

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance

2020 ◽  
Vol 52 ◽  
pp. 68-75 ◽  
Author(s):  
Deblina Bharadwaj ◽  
Mahitosh Mandal
Keyword(s):  
Cancer Cells ◽  
Polyploid Giant Cancer Cells

The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance

2019 ◽  
Vol 146 (8) ◽  
pp. 2078-2088 ◽  
Author(s):  
Jiahao Shi ◽  
Yongyun Li ◽  
Renbing Jia ◽  
Xianqun Fan
Keyword(s):  
Cancer Cells ◽  
Clinical Significance ◽  
Pdx Models

scholarly journals Asymmetric Cell Division in Polyploid Giant Cancer Cells and Low Eukaryotic Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dan Zhang ◽  
Yijia Wang ◽  
Shiwu Zhang
Keyword(s):  
Cell Division ◽  
Cancer Cells ◽  
Cobalt Chloride ◽  
Asymmetric Cell Division ◽  
Cell Polarization ◽  
Daughter Cells ◽  
Evolutionarily Conserved ◽  
Polyploid Giant Cancer Cells ◽  
Cell Diversity ◽  
Eukaryotic Organisms

Asymmetric cell division is critical for generating cell diversity in low eukaryotic organisms. We previously have reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride demonstrate the ability to use an evolutionarily conserved process for renewal and fast reproduction, which is normally confined to simpler organisms. The budding yeast,Saccharomyces cerevisiae, which reproduces by asymmetric cell division, has long been a model for asymmetric cell division studies. PGCCs produce daughter cells asymmetrically in a manner similar to yeast, in that both use budding for cell polarization and cytokinesis. Here, we review the results of recent studies and discuss the similarities in the budding process between yeast and PGCCs.

Clinical significance of quantitative analysis of carcinoembryonic antigen assessed by flow cytometry in fresh human gastric cancer cells

1995 ◽  
Vol 90 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Mikiko Tamai ◽  
Hiroshi Tanimura ◽  
Hiroki Yamaue ◽  
Makoto Iwahashi ◽  
Takuya Tsunoda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Flow Cytometry ◽  
Quantitative Analysis ◽  
Carcinoembryonic Antigen ◽  
Cancer Cells ◽  
Clinical Significance ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

Abstract 1917: Re-thinking the concept of cancer stem cells: Polyploid giant cancer cells as mother cancer stem cells

2014 ◽  
Author(s):  
Jinsong Liu ◽  
Imelda Mercado-Uribe ◽  
Na Niu ◽  
Baocun Sun ◽  
Jian Kuang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Polyploid Giant Cancer Cells
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