Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

2018 ◽  
Vol 18 (6) ◽  
pp. 1800011 ◽  
Author(s):  
Johana Plch ◽  
Kristyna Venclikova ◽  
Olga Janouskova ◽  
Jan Hrabeta ◽  
Tomas Eckschlager ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Antitumor Activity ◽  
Drug Carrier ◽  
Potential Drug ◽  
Local Chemotherapy

scholarly journals Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 993
Author(s):  
Richa Chaturvedi ◽  
Yumin Kang ◽  
Yunji Eom ◽  
Sri Ramulu Torati ◽  
CheolGi Kim
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Carrier ◽  
Magnetotactic Bacteria ◽  
Biological Applications ◽  
Potential Drug ◽  
Time Saving ◽  
Area Of Interest ◽  
Cell Association

The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG–biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocytosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG–biotin to the MTB-through-NHS crosslinker to form a MTB/PEG–biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG–biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG–biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell’s surface, so as to make it a strong and reliable delivery agent.

Nanostructured Lipid Carriers (NLCs) for drug delivery: Role of Liquid lipid (oil)

2020 ◽  
Vol 17 ◽  
Author(s):  
Anisha D’Souza ◽  
Ranjita Shegokar
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Drug Carrier ◽  
Drug Loading ◽  
Performance Criteria ◽  
Long Term Stability ◽  
Natural Oils ◽  
Optimal Drug

: In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

scholarly journals Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Fiona C. Simpson ◽  
Christopher D. McTiernan ◽  
Mohammad Mirazul Islam ◽  
Oleksiy Buznyk ◽  
Philip N. Lewis ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Nerve Regeneration ◽  
Graft Failure ◽  
Corneal Stroma ◽  
Advanced Stage ◽  
Term Survival ◽  
Corneal Regeneration ◽  
Type V ◽  
Mini Pigs

AbstractThe long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The resulting CLP-PEG-MPC implants led to reduced corneal swelling, haze, and neovascularization in comparison to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. Implants incorporating MPC allowed for faster nerve regeneration and recovery of corneal sensation. CLP-PEG-MPC implants appear to be at a more advanced stage of regeneration than the CLP-PEG only implants, as evidenced by the presence of higher amounts of cornea-specific type V collagen, and a corresponding decrease in the presence of extracellular vesicles and exosomes in the corneal stroma, in keeping with the amounts present in healthy, unoperated corneas.

Hollow poly(MPC-g-PEG-b-PLA) graft copolymer microcapsule as a potential drug carrier

2012 ◽  
Vol 29 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Chaoyong Liu ◽  
Lixia Long ◽  
Zhi Li ◽  
Bin He ◽  
Liuheng Wang ◽  
...  
Keyword(s):  
Graft Copolymer ◽  
Drug Carrier ◽  
Potential Drug

Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38810-38817 ◽  
Author(s):  
Yeping Li ◽  
Jingbo Xu ◽  
Yun Xu ◽  
Liying Huang ◽  
Junli Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Zns Nanoparticles ◽  
New Approach ◽  
Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

PEG-PLA Block Copolymer as Potential Drug Carrier: Preparation and Characterization

2006 ◽  
Vol 6 (12) ◽  
pp. 1019-1025 ◽  
Author(s):  
Shimon Ben-Shabat ◽  
Neeraj Kumar ◽  
Abraham J. Domb
Keyword(s):  
Block Copolymer ◽  
Drug Carrier ◽  
Potential Drug

Mechanistic Approach for Long-Term Stability of a Polyethylene Glycol–Carbon Black Nanocomposite Sensor

ACS Sensors ◽  
2021 ◽  
Author(s):  
Wenjun Li ◽  
Kazuki Nagashima ◽  
Takuro Hosomi ◽  
Chen Wang ◽  
Yosuke Hanai ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Carbon Black ◽  
Term Stability ◽  
Long Term Stability ◽  
Mechanistic Approach ◽  
Nanocomposite Sensor

scholarly journals Preparation and comparison of bulk and membrane hydrogels based on Kraft- and ionic-liquid-isolated lignins

2016 ◽  
Vol 18 (20) ◽  
pp. 5607-5620 ◽  
Author(s):  
Xiaoping Shen ◽  
Paula Berton ◽  
Julia L. Shamshina ◽  
Robin D. Rogers
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Polyethylene Glycol ◽  
Alkaline Solution ◽  
Wound Dressing ◽  
Food Packaging ◽  
Potential Drug

Lignin-based hydrogels in both bulk and membrane forms for potential drug delivery, food packaging, and wound dressing applications have been designed by crosslinking ionic-liquid-isolated lignin with epoxide-terminated polyethylene glycol (ETPEG) in alkaline solution.

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