scholarly journals Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 993
Author(s):  
Richa Chaturvedi ◽  
Yumin Kang ◽  
Yunji Eom ◽  
Sri Ramulu Torati ◽  
CheolGi Kim
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Carrier ◽  
Magnetotactic Bacteria ◽  
Biological Applications ◽  
Potential Drug ◽  
Time Saving ◽  
Area Of Interest ◽  
Cell Association

The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG–biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocytosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG–biotin to the MTB-through-NHS crosslinker to form a MTB/PEG–biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG–biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG–biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell’s surface, so as to make it a strong and reliable delivery agent.

scholarly journals Preparation and comparison of bulk and membrane hydrogels based on Kraft- and ionic-liquid-isolated lignins

2016 ◽  
Vol 18 (20) ◽  
pp. 5607-5620 ◽  
Author(s):  
Xiaoping Shen ◽  
Paula Berton ◽  
Julia L. Shamshina ◽  
Robin D. Rogers
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Polyethylene Glycol ◽  
Alkaline Solution ◽  
Wound Dressing ◽  
Food Packaging ◽  
Potential Drug

Lignin-based hydrogels in both bulk and membrane forms for potential drug delivery, food packaging, and wound dressing applications have been designed by crosslinking ionic-liquid-isolated lignin with epoxide-terminated polyethylene glycol (ETPEG) in alkaline solution.

Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

2018 ◽  
Vol 18 (6) ◽  
pp. 1800011 ◽  
Author(s):  
Johana Plch ◽  
Kristyna Venclikova ◽  
Olga Janouskova ◽  
Jan Hrabeta ◽  
Tomas Eckschlager ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Antitumor Activity ◽  
Drug Carrier ◽  
Potential Drug ◽  
Local Chemotherapy

scholarly journals Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release

2018 ◽  
Vol 2018 ◽  
pp. 1-14
Author(s):  
Rui Zhang ◽  
Benjamin Fellows ◽  
Nikorn Pothayee ◽  
Nan Hu ◽  
Nipon Pothayee ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Aqueous Media ◽  
Potential Drug ◽  
Resonance Imaging ◽  
Temperature Dependent ◽  
Hyperthermia Treatment

Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.

In vitro evaluation of mucoadhesive and self-disinfection efficiency of (acrylic acid/polyethylene glycol)-silver nanocomposites for buccal drug delivery

2017 ◽  
Vol 33 (1) ◽  
pp. 95-115 ◽  
Author(s):  
Amany I Raafat ◽  
Ghada A Mahmoud ◽  
Amr El-Hag Ali ◽  
Nagwa A Badawy ◽  
Mai F Elshahawy
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Drug Carrier ◽  
Copolymer Composition ◽  
Bacterial Strains ◽  
Γ Irradiation ◽  
X Ray ◽  
Propranolol Hcl ◽  
Buccal Drug Delivery

A mucoadhesive drug delivery system can improve the effectiveness of a drug, allowing targeting and localization at a specific site. According to this assumption, γ-irradiation as eco-friendly technique was employed to synthesize (acrylic acid/polyethylene glycol) copolymer hydrogel of different compositions. Silver nanoparticles were prepared within (acrylic acid/polyethylene glycol) hydrogel network by means of in situ reduction of silver nitrate using sodium borohydride as a reducing agent. Swelling characteristics in distilled water and simulated saliva solution were studied as a function of copolymer composition and preparation irradiation dose. (Acrylic acid/polyethylene glycol) hydrogels and their developed Agº nanocomposites have been characterized using scanning electron microscope, thermogravimetric analysis, transmission electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Mucoadhesive strength as well as self-disinfection efficiency expressed as antibacterial activity against different bacterial strains was evaluated. Propranolol HCl as model drug was used to evaluate the potential efficiency of the obtained (acrylic acid/polyethylene glycol)-Agº nanocomposites as mucoadhesive drug carrier. The obtained results showed that the (acrylic acid/polyethylene glycol)-Agº nanocomposites show a promising self-disinfection property, and the propranolol HCl–loaded composites were able to deliver the loaded drug in a sustainable manner that lasts for about 600 min.

Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86361-86372 ◽  
Author(s):  
Hyun Jin Lee ◽  
Seung-Hae Kwon ◽  
Kwang-Suk Jang
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Size Distribution ◽  
Thermodynamic Stability ◽  
Drug Carrier ◽  
Potential Drug ◽  
Narrow Size Distribution ◽  
High Thermodynamic Stability ◽  
Delivery Platform

Ultrasmall polymersomes are suggested as a drug delivery platform based on their suitable size, narrow size distribution, uniform morphology, and high thermodynamic stability.

Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Release Mechanism ◽  
Innovative Drug ◽  
Pharmaceutical Excipients ◽  
Weight Variation

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

Nanostructured Lipid Carriers (NLCs) for drug delivery: Role of Liquid lipid (oil)

2020 ◽  
Vol 17 ◽  
Author(s):  
Anisha D’Souza ◽  
Ranjita Shegokar
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Drug Carrier ◽  
Drug Loading ◽  
Performance Criteria ◽  
Long Term Stability ◽  
Natural Oils ◽  
Optimal Drug

: In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

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