scholarly journals Long non-coding RNA AGER-1 functionally upregulates the innate immunity gene AGER and approximates its anti-tumor effect in lung cancer

2017 ◽  
Vol 57 (3) ◽  
pp. 305-318 ◽  
Author(s):  
Zihua Pan ◽  
Li Liu ◽  
Wenjing Nie ◽  
Sinead Miggin ◽  
Fuman Qiu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Innate Immunity ◽  
Immunity Gene ◽  
Non Coding Rna ◽  
Innate Immunity Gene ◽  
Long Non Coding Rna

scholarly journals Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene

2007 ◽  
Vol 99 (18) ◽  
pp. 1401-1409 ◽  
Author(s):  
Sharon R. Pine ◽  
Leah E. Mechanic ◽  
Stefan Ambs ◽  
Elise D. Bowman ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Innate Immunity ◽  
Cancer Survival ◽  
Immunity Gene ◽  
Functional Polymorphisms ◽  
Innate Immunity Gene ◽  
Lung Cancer Survival

scholarly journals Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Yu Zhong ◽  
Liting Yang ◽  
Fang Xiong ◽  
Yi He ◽  
Yanyan Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Cancer Metastasis ◽  
Lung Cancer Cells ◽  
Migration And Invasion ◽  
Lung Cancer Patients ◽  
Lung Cancer Metastasis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

AbstractActin filament associated protein 1 antisense RNA 1 (named AFAP1-AS1) is a long non-coding RNA and overexpressed in many cancers. This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer. The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization. The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells. To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer, we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses. AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients’ poor prognosis. In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis. AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1 (named SNIP1), which inhibited ubiquitination and degradation of c-Myc protein. Upregulation of c-Myc molecule in turn promoted the expression of ZEB1, ZEB2, and SNAIL gene, which ultimately enhanced epithelial to mesenchymal transition (EMT) and lung cancer metastasis. Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer’s migration and invasion may provide novel therapeutic targets for lung cancer patients’ early diagnosis and therapy.

scholarly journals Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis in human lung cancer cells

2018 ◽  
Author(s):  
Yang Guo ◽  
Ying Hu ◽  
Mingming Hu ◽  
Jiabei He ◽  
Baolan Li
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Non Coding Rna ◽  
Human Lung Cancer Cells ◽  
Long Non Coding Rna

Long non-coding RNA DARS-AS1 promotes tumorigenesis of non-small cell lung cancer via targeting miR-532-3p

2021 ◽  
Vol 112 (3) ◽  
Author(s):  
Dongguo LIU ◽  
Haibo LIU ◽  
Zongpeng JIANG ◽  
Minglian CHEN ◽  
Shuncui GAO
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA AK001796 contributes to cisplatin resistance of non-small cell lung cancer

2017 ◽  
Vol 16 (4) ◽  
pp. 4107-4112 ◽  
Author(s):  
Bin Liu ◽  
Chun-Feng Pan ◽  
Teng Ma ◽  
Jun Wang ◽  
Guo-Liang Yao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cisplatin Resistance ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Yafeng Fan ◽  
Hongxia Li ◽  
Zhongping Yu ◽  
Wen Dong ◽  
Xiaoyan Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Small Cell ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Long non-coding RNA (lncRNA) FYVE, RhoGEF and PH domain containing 5 antisense RNA 1 (FGD5-AS1) has been reported as an oncogene in colorectal cancer, promoting its tumorgenesis. The present paper focused on searching the potential function of FGD5-AS1 in non-small cell lung carcinoma (NSCLC). There are connections between the expression of lncRNA FGD5-AS1 and human NSCLC tumor growth and progression. Also, the relationships between FGD5-AS1, hsa-miR-107 and mRNA fibroblast growth factor receptor like 1 (FGFRL1) are going to test their interaction in NSCLC cell lines, which may cause a series of biological behaviors of NSCLC cells. qRT-PCR analysis was conducted to test the expression of RNAs in different situation. CCK-8 experiment and clone formation assay were performed to assess proliferation of NSCLC cells. Also, connection between FGD5-AS1 and hsa-miR-107 were investigated by luciferase reporter assay and RNA pull-down assay. Rescue experiments were performed to verify the modulating relationship between FGD5-AS1, hsa-miR-107 and FGFRL1. High-level expression of FGD5-AS1 was found in NSCLC. FGD5-AS1 may promote the proliferation of NSCLC cells. Also, the combination between hsa-miR-107, FGD5-AS1 and NSCLC have been proved, which means they can play an interaction function in NSCLC cells. Thence, we concluded that lncRNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1.

Long non-coding RNA functions in lung cancer

Tumor Biology ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 4027-4037 ◽  
Author(s):  
Haiwei Sang ◽  
Haihong Liu ◽  
Peng Xiong ◽  
Min Zhu
Keyword(s):  
Lung Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2

Cell Cycle ◽  
2018 ◽  
Vol 17 (10) ◽  
pp. 1188-1198 ◽  
Author(s):  
Yuheng Tian ◽  
Nali Zhang ◽  
Shuwen Chen ◽  
Yuan Ma ◽  
Yanyan Liu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA AFAP1-AS1 plays an oncogenic role in promoting cell migration in non-small cell lung cancer

2018 ◽  
Vol 75 (24) ◽  
pp. 4667-4681 ◽  
Author(s):  
Juan He ◽  
Ke Wu ◽  
Chenglin Guo ◽  
Jian-Kang Zhou ◽  
Wenchen Pu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Migration ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals A Human Long Non-coding RNA LncATV Promotes Virus Replication Through Restricting RIG-I–Mediated Innate Immunity

2019 ◽  
Vol 10 ◽  
Author(s):  
Jingjing Fan ◽  
Min Cheng ◽  
Xiaojing Chi ◽  
Xiuying Liu ◽  
Wei Yang
Keyword(s):  
Innate Immunity ◽  
Virus Replication ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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