In the field of heterocyclic medicinal chemistry, especially five-membered ring
structures containing a nitrogen atom, imidazole core is an imperative aromatic heterocycle which
is usually present in naturally occurring products and synthetic bioactive molecules. The
occurrence of imidazole moiety in therapeutic compounds may be beneficial in terms of improving
water-soluble properties due to its two nitrogen atoms which leads to the creation of hydrogen
bonds. The imidazole nucleus has also been recognized as an important isostere of triazole,
pyrazole, thiazole, tetrazole, oxazole, amide etc. for the purpose of designing and development of
various biologically active molecules. Moreover, imidazole core as an attractive binding site could
interact with diverse cations and anions as well as biomolecules through different reactions in the
human biological system thus displaying extensive biological activities. This effort thoroughly
provides a wide-ranging assessment in current drug discovery and developments of imidazolebased
analogues in the entire series of synthetic medicinal chemistry as antibacterial and
antifungal, anticancer, anti-tubercular, analgesic and anti-inflammatory, anti-neuropathic,
antihypertensive, anti-allergic, anti-parasitic, antiviral, antidepressant, anti-obesity and so on,
altogether with their prospective approaches in diagnostic and pathological field. It is expected
that the present review will be supportive on behalf of new opinions in the search for rational
strategies of more efficacious and less toxic medicinal agents and drugs containing imidazole core.
Expanding Roles for Organoboron Compounds – Versatile and Valuable Molecules for Synthetic, Biological and Medicinal Chemistry
