Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study

2019 ◽  
Vol 63 (19) ◽  
pp. 1900167 ◽  
Author(s):  
Carolina Gutiérrez‐Repiso ◽  
Carmen Hernández‐García ◽  
José Manuel García‐Almeida ◽  
Diego Bellido ◽  
Gracia María Martín‐Núñez ◽  
...  
2020 ◽  
Vol 17 ◽  
pp. 101061 ◽  
Author(s):  
Lauren P. Cleveland ◽  
Michael W. Seward ◽  
Denise Simon ◽  
Sheryl L. Rifas-Shiman ◽  
Kristina H. Lewis ◽  
...  

Nutrients ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 337 ◽  
Author(s):  
Diego Moreno-Pérez ◽  
Carlo Bressa ◽  
María Bailén ◽  
Safa Hamed-Bousdar ◽  
Fernando Naclerio ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1829
Author(s):  
Silvio Buscemi ◽  
Carola Buscemi ◽  
Davide Corleo ◽  
Giovanni De Pergola ◽  
Rosalia Caldarella ◽  
...  

Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40; p < 0.05) and body mass index (r = −0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss.


2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Jennifer E Lambert ◽  
Jill A Parnell ◽  
Jay Han ◽  
Troy Sturzenegger ◽  
Heather A Paul ◽  
...  

2021 ◽  
Vol 70 (12) ◽  
Author(s):  
Tingting Tu ◽  
Changlin Zhao

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders with a high prevalence in childhood. The gut microbiota can affect human cognition and moods and has a strong correlation with ASD. Microbiota transplantation, including faecal microbiota transplantation (FMT), probiotics, breastfeeding, formula feeding, gluten-free and casein-free (GFCF) diet and ketogenic diet therapy, may provide satisfying effects for ASD and its related various symptoms. For instance, FMT can improve the core symptoms of ASD and gastrointestinal symptoms. Probiotics, breastfeeding and formula feeding, and GFCF diet can improve gastrointestinal symptoms. The core symptom score still needs to be confirmed by large-scale clinical randomized controlled studies. It is recommended to use a ketogenic diet to treat patients with epilepsy in ASD. At present, the unresolved problems include which of gut the microbiota are beneficial, which of the microorganisms are harmful, how to safely and effectively implant beneficial bacteria into the human body, and how to extract and eliminate harmful microorganisms before transplantation. In future studies, large sample and randomized controlled clinical studies are needed to confirm the mechanism of intestinal microorganisms in the treatment of ASD and the method of microbial transplantation.


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