Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution

Gut microbiota is well known as playing a critical role in inflammation and asthma development. The very low-calorie ketogenic diet (VLCKD) is suggested to affect gut microbiota; however, the effects of VLCKD during pregnancy and lactation on the infant gut microbiota are unclear. The VLCKD appears to be more effective than caloric/energy restriction diets for the treatment of several diseases, such as obesity and diabetes. However, whether adherence to VLCKD affects the infant gut microbiota and the protective effects thereof on asthma remains uncertain. The exact mechanisms underlying this process, and in particular the potential role of short chain fatty acids (SCFAs), are still to be unravelled. Thus, the aim of this review is to identify the potential role of SCFAs that underlie the effects of VLCKD during pregnancy and lactation on the infant gut microbiota, and explore whether it incurs significant implications for reducing asthma.

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Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201900167 ◽

2019 ◽

Vol 63 (19) ◽

pp. 1900167 ◽

Cited By ~ 3

Author(s):

Carolina Gutiérrez‐Repiso ◽

Carmen Hernández‐García ◽

José Manuel García‐Almeida ◽

Diego Bellido ◽

Gracia María Martín‐Núñez ◽

...

Keyword(s):

Weight Loss ◽

Pilot Study ◽

Gut Microbiota ◽

Ketogenic Diet ◽

Low Calorie ◽

Randomized Controlled ◽

Synbiotic Supplementation

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The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity

Nutrients ◽

10.3390/nu13113702 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3702

Author(s):

Naser A. Alsharairi

Keyword(s):

Gut Microbiota ◽

Ketogenic Diet ◽

Therapeutic Potential ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Protective Effects ◽

Low Calorie ◽

Pregnancy And Lactation ◽

Gut Microbiota Composition

As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic approach for many diseases, little is known about its therapeutic use in childhood obesity. Indeed, the role of VLCKD during pregnancy and lactation in influencing short chain fatty acid (SCFA)-producing bacteria and the potential mechanisms involved in the protective effects on obesity are still unclear. Infants are characterized by a diverse gut microbiota composition with higher abundance of SCFA-producing bacteria. Maternal VLCKD during pregnancy and lactation stimulates the growth of diverse species of SCFA-producing bacteria, which may induce epigenetic changes in infant obese gene expression and modulate adipose tissue inflammation in obesity. Therefore, this review aims to determine the mechanistic role of SCFAs in mediating VLCKD-infant gut microbiota relationships and its protective effects on obesity.

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