scholarly journals Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI

2018 ◽  
Vol 80 (6) ◽  
pp. 2655-2669 ◽  
Author(s):  
Feng Wang ◽  
Daisuke Katagiri ◽  
Ke Li ◽  
Keiko Takahashi ◽  
Suwan Wang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Fibrosis ◽  
Magnetization Transfer ◽  
Magnetization Transfer Mri

scholarly journals Protective Effects of Ethanolic Extract from Rhizome of Polygoni avicularis against Renal Fibrosis and Inflammation in a Diabetic Nephropathy Model

2021 ◽  
Vol 22 (13) ◽  
pp. 7230
Author(s):  
Jung-Joo Yoon ◽  
Ji-Hun Park ◽  
Yun-Jung Lee ◽  
Hye-Yoom Kim ◽  
Byung-Hyuk Han ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Renal Dysfunction ◽  
Renal Fibrosis ◽  
Mesangial Cells ◽  
Resistance Index ◽  
Ethanolic Extract ◽  
Glomerular Sclerosis ◽  
Oral Glucose ◽  
Inflammatory Factor

Progressive diabetic nephropathy (DN) in diabetes leads to major morbidity and mortality. The major pathological alterations of DN include mesangial expansion, extracellular matrix alterations, tubulointerstitial fibrosis, and glomerular sclerosis. Polygoni avicularis is widely used in traditional oriental medicine and has long been used as a diuretic, astringent, insecticide and antihypertensive. However, to the best of the authors’ knowledge, the effects of the ethanolic extract from rhizome of Polygoni avicularis (ER-PA) on DN have not yet been assessed. The present study aimed to identify the effect of ER-PA on renal dysfunction, which has been implicated in DN in human renal mesangial cells and db/db mice and investigate its mechanism of action. The in vivo experiment was performed using Polygoni avicularis-ethanol soluble fraction (ER-PA) and was administrated to db/db mice at 10 and 50 mg/kg dose. For the in vitro experiments, the human renal mesangial cells were induced by high glucose (HG, 25 mM). The ER-PA group showed significant amelioration in oral glucose tolerance, and insulin resistance index. ER-PA significantly improved the albumin excretion and markedly reduced plasma creatinine, kidney injury molecule-1 and C-reactive protein. In addition, ER-PA significantly suppressed inflammatory cytokines. Histopathologically, ER-PA attenuated glomerular expansion and tubular fibrosis in db/db mice. Furthermore, ER-PA suppressed the expression of renal fibrosis biomarkers (TGF and Collagen IV). ER-PA also reduced the NLR family pyrin domain containing 3 inflammatory factor level. These results suggest that ER-PA has a protective effect against renal dysfunction through improved insulin resistance as well as the inhibition of nephritis and fibrosis in DN.

scholarly journals Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI

2009 ◽  
Vol 29 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Francesca Schiavone ◽  
Rebecca Ann Charlton ◽  
Thomas Richard Barrick ◽  
Robin Guy Morris ◽  
Hugh Stephen Markus
Keyword(s):  
Cognitive Decline ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Age Related ◽  
Magnetization Transfer Mri ◽  
Age Related Cognitive Decline

scholarly journals LncRNA lnc‐ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR‐486‐5p/NFAT5

2021 ◽  
Author(s):  
Yu‐Rui Duan ◽  
Bao‐Ping Chen ◽  
Fang Chen ◽  
Su‐Xia Yang ◽  
Chao‐Yang Zhu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Fibrosis ◽  
Akt Phosphorylation

scholarly journals Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy

2018 ◽  
Vol Volume 12 ◽  
pp. 3517-3524 ◽  
Author(s):  
Na Du ◽  
Zhiping Xu ◽  
Mingyue Gao ◽  
Peng Liu ◽  
Bo Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Renal Fibrosis ◽  
Signaling Cascade ◽  
Ginsenoside Rg1 ◽  
Tgf Beta ◽  
Astragaloside Iv

scholarly journals The combination of ursolic acid and empagliflozin relieves diabetic nephropathy by reducing inflammation, oxidative stress and renal fibrosis

2021 ◽  
Vol 144 ◽  
pp. 112267
Author(s):  
Xiaohan Wu ◽  
He Li ◽  
Zhijie Wan ◽  
Ran Wang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Ursolic Acid ◽  
Renal Fibrosis
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