Discovery of Antimicrobial Agent Targeting Tryptophan Synthase

Protein Science ◽

10.1002/pro.4236 ◽

2021 ◽

Author(s):

Yuliana K. Bosken ◽

Rizi Ai ◽

Eduardo Hilario ◽

Rittik K. Ghosh ◽

Michael F. Dunn ◽

...

Keyword(s):

Antimicrobial Agent ◽

Tryptophan Synthase

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Silver Nano-Particles from Diesel Particulate Matter: An Environmental Pollutant to a Potential Antimicrobial Agent and a Photocatalyst

International Journal of Scientific and Research Publications (IJSRP) ◽

10.29322/ijsrp.9.05.2019.p8992 ◽

2019 ◽

Vol 9 (5) ◽

pp. p8992

Author(s):

L. Palliyaguru ◽

M.U.S. Kulatunga ◽

K.G.U.R. Kumarasinghe ◽

S.S.N. Fernando ◽

T.D.C.P. Gunasekara ◽

...

Keyword(s):

Particulate Matter ◽

Antimicrobial Agent ◽

Environmental Pollutant ◽

Nano Particles ◽

Diesel Particulate Matter ◽

Diesel Particulate

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Faculty Opinions recommendation of A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727772309.793534094 ◽

2017 ◽

Author(s):

Andrea Mozzarelli

Keyword(s):

Mycobacterium Tuberculosis ◽

Small Molecule ◽

Tryptophan Synthase ◽

Allosteric Inhibitor

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APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

Knowledge International Journal ◽

10.35120/kij2802429z ◽

2018 ◽

Vol 28 (2) ◽

pp. 429-432

Author(s):

Dilyana Zvezdova

Keyword(s):

Wound Healing ◽

Antibacterial Activity ◽

Fourier Transform ◽

Infrared Spectroscopy ◽

Antimicrobial Agent ◽

Defense Mechanisms ◽

Solvent Casting ◽

Casting Method ◽

Gram Negative ◽

Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

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Enzymatic Synthesis of L-Tryptophan Catalyzed by Tryptophan Synthase in a Water/Organic Solvent Biphase System

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) ◽

10.3724/sp.j.1088.2011.10349 ◽

2014 ◽

Vol 32 (8) ◽

pp. 1405-1410

Author(s):

Lisheng XU ◽

Junzhong LIU ◽

Zhiyuan WANG ◽

Hongjuan ZHANG ◽

Wei LIU ◽

...

Keyword(s):

Organic Solvent ◽

Enzymatic Synthesis ◽

Tryptophan Synthase

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Screening compounds of Chinese herbal medicine and antimicrobial agent for controlling bacterial diseases of eels

Journal of Fishery Sciences of China ◽

10.3724/sp.j.1118.2011.00230 ◽

2013 ◽

Vol 18 (1) ◽

pp. 230-236 ◽

Author(s):

Wenshu HUANG ◽

Xuehao CHEN ◽

Ying LIANG ◽

Songlin GUO ◽

Ruizhang GUAN

Keyword(s):

Herbal Medicine ◽

Antimicrobial Agent ◽

Chinese Herbal Medicine ◽

Bacterial Diseases ◽

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Purification and Biological Evaluation of Some Bioactive Metabolomics as Antimicrobial Agent

Letters in Drug Design & Discovery ◽

10.2174/1570180811310050011 ◽

2013 ◽

Vol 10 (5) ◽

pp. 437-443

Author(s):

Ramar Perumal Samy ◽

Gautam Sethi ◽

Vincent T.K Chow

Keyword(s):

Antimicrobial Agent ◽

Biological Evaluation

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The effect of free amino acids and related compounds on the activity of plant enzymes. I. Effect of DL-threonine, L-proline, γ-aminobutyric acid, L-asparagine and L-cysteine on the activity of tryptophan synthase (4.2.1.20) in living bean leaf (Phaseolus vulgaris L.)

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19713323 ◽

1971 ◽

Vol 36 (9) ◽

pp. 3323-3331

Author(s):

M. Štefl ◽

I. Trčka

Keyword(s):

Amino Acids ◽

Phaseolus Vulgaris ◽

Free Amino Acids ◽

Aminobutyric Acid ◽

Tryptophan Synthase ◽

Phaseolus Vulgaris L ◽

Plant Enzymes ◽

Related Compounds

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Isomerization of (3S)-2,3-dihydro-5-fluoro-L-tryptophan and of 5-fluoro-L-tryptophan catalyzed by tryptophan synthase: studies using fluorine-19 nuclear magnetic resonance and difference spectroscopy

Biochemistry ◽

10.1021/bi00363a011 ◽

1986 ◽

Vol 25 (15) ◽

pp. 4240-4249 ◽

Author(s):

Edith Wilson Miles ◽

Robert S. Phillips ◽

Herman J. C. Yeh ◽

Louis A. Cohen

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Tryptophan Synthase ◽

Difference Spectroscopy ◽

Nuclear Magnetic

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Thermal inactivation of tryptophan synthase. Stabilization by protein-protein interaction and protein-ligand interaction.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)32629-7 ◽

1994 ◽

Vol 269 (16) ◽

pp. 11703-11706

Author(s):

S.B. Ruvinov ◽

E.W. Miles

Keyword(s):

Protein Interaction ◽

Thermal Inactivation ◽

Tryptophan Synthase ◽

Ligand Interaction ◽

Protein Protein Interaction ◽

Protein Ligand Interaction

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Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42377-0 ◽

1992 ◽

Vol 267 (18) ◽

pp. 13028-13038

Author(s):

P.S. Brzović ◽

Y Sawa ◽

C.C. Hyde ◽

E.W. Miles ◽

M.F. Dunn

Keyword(s):

Alpha Subunit ◽

Tryptophan Synthase ◽

Closed Conformation ◽

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