APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

scholarly journals PVP Based Materials: Biodegradation in Different Environments

2017 ◽  
Vol 24 (2) ◽  
pp. 299-309 ◽  
Author(s):  
Ludmila Vanharova ◽  
Marketa Julinova ◽  
Roman Slavik
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Polylactic Acid ◽  
Fourier Transform Infrared ◽  
Solvent Casting ◽  
Casting Technique ◽  
Scanning Electron

AbstractThe research deals with biodegradation of films prepared from polyvinylpyrrolidone and polylactic acid (PVP/PLA). Biodegradation of PVP/PLA films was supported by the following additives: 1-methyl-2-pyrrolidone, 1-octyl-2-pyrrolidone, acrylamide and N-acetyl-L-phenylalanine according to the previous study. The films were prepared by a solvent casting technique. Biodegradation was observed using the respirometric method in different environments. The films subjected to biodegradation were analyzed by scanning electron microscopy and Fourier transform infrared spectroscopy. It was found that the films are substantially degraded, but not in the biological way; PVP was quickly removed in presence of water because of its easy solubility. In contrast, this fact could support biodegradation of PLA, which becomes more available for microorganisms when PVP leaves PLA matrix.

Easy Preparation of Bacterial Cellulose/Triamcinolone Acetonide Composites and their Inhibition for Fibroblasts

2018 ◽  
Vol 913 ◽  
pp. 707-713
Author(s):  
Miao Ying Jin ◽  
Shi Yan Chen ◽  
Bao Xiu Wang ◽  
Hua Ping Wang
Keyword(s):  
Wound Healing ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Drug Release ◽  
Sustained Release ◽  
Bacterial Cellulose ◽  
Triamcinolone Acetonide ◽  
Wound Dressing ◽  
Impregnation Method ◽  
Relieve Pain

Wound healing is accompanied by keloids, it is important to develop a wound dressing which can inhibit keloid and relieve pain and pruritus in patients. In this paper, bacterial cellulose/triamcinolone acetonide (BC/TA) composites are prepared by easy solution impregnation method, which the structures of BC/TA composites were analyzed by fourier transform infrared spectroscopy (FTIR). The drug release and inhibition of L929 cells were also analyzed. It can be concluded that BC/TA composites have a sustained release effect on TA and can effectively inhibit proliferation of L929 in the range of 0.5-2.0 mg/cm2.

scholarly journals Using least angular regression to model the antibacterial potential of metronidazole complexes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tahir Mehmood ◽  
Mudassir Iqbal ◽  
Bushra Rafique
Keyword(s):  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Mean Square ◽  
E Coli ◽  
Asymmetric Least Squares ◽  
Selection Operators ◽  
Antitumor Properties ◽  
Antibacterial Medication ◽  
Antibacterial Potential

AbstractImidazole has anti-inflammatory, antituberculotic, antimicrobial, antimycotic, antiviral, and antitumor properties in the human body, to name a few. Metronidazole [1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole] is a widely used antiprotozoan and antibacterial medication. Using fourier transform infrared spectroscopy, the current study models the antibacterial activity of already synthesised Metronidazole (MTZ) complexes ($$MTZ-Benz$$ M T Z - B e n z , $$MTZ-Benz-Cu$$ M T Z - B e n z - C u , $$MTZ-Benz-Cu-Cl_2CHCOOH$$ M T Z - B e n z - C u - C l 2 C H C O O H , $$MTZ$$ MTZ , $$MTZ-Cu$$ M T Z - C u , $$MTZ-Cu-Cl_2CHCOOH$$ M T Z - C u - C l 2 C H C O O H , $$MTZ-Benz-Ag$$ M T Z - B e n z - A g , $$MTZ-Benz-Ag-Cl_2CHCOOH$$ M T Z - B e n z - A g - C l 2 C H C O O H , $$MTZ-Ag$$ M T Z - A g and $$MTZ-Ag-Cl_2CHCOOH$$ M T Z - A g - C l 2 C H C O O H ) against E. coli, B. bronceptica, S. epidermidis, B. pumilus and S. aureus. To characterise the Metronidazole complexes for antibacterial activity against 05 microbes, the least angular regression and least absolute shrinkage selection operators were used. Asymmetric Least Squares was used to correct the spectrum baseline. Least angular regression outperforms cross-validated root mean square error in the fitted models. Using Least angular regression, influential wavelengths that explain the variation in antibacterial activity of Metronidazole complexes were identified and mapped against functional groups.

scholarly journals Antibacterial activity and effects of aromatic derivatives on denture base polymerization.

2019 ◽  
Vol S (1) ◽  
pp. 24-27
Author(s):  
Ammar AG. Alhamdani ◽  
◽  
Arjwan M. Shuker ◽  
Inas A. Jawad ◽  
◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Oral Cavity ◽  
Polymerization Process ◽  
Negative Effects ◽  
Denture Base ◽  
Plant Extraction ◽  
Methacrylate Monomer ◽  
Methyl Methacrylate Monomer

This study assessed the effect of copolymerization on the microbiota of the oral cavity. The plant extraction was converted into aromatic derivatives, which were added to methyl methacrylate monomer. Fourier transform infrared spectroscopy spectra showed no negative effects of these additives on the polymerization process. All the assayed derivatives displayed some degree of antibacterial activity.

Straightforward Synthesis of Cost-Effective, Flexible, and Hydrophobic Polyaniline-Chitosan (PAni-Cs) Films Produced with Lactic Acid as Solvent

2021 ◽  
Vol 1041 ◽  
pp. 29-35
Author(s):  
Bianca Rae Pasela ◽  
Rayda P. Gammag ◽  
Acelle Pearl T. Castillo ◽  
Doebner von C. Tumacder ◽  
Kathrina Lois Taaca
Keyword(s):  
Acetic Acid ◽  
Fourier Transform ◽  
Lactic Acid ◽  
Physical Properties ◽  
Ftir Spectroscopy ◽  
Cost Effective ◽  
Solvent Casting ◽  
Casting Method ◽  
Surface Energies ◽  
Facile Preparation

In this study, facile preparation using a new solvent – lactic acid and physical properties of PAni-Cs films are observed. The main goal of the study is to easily synthesize PAni-Cs films using lactic acid as solvent through the solvent casting method and investigate if producing PAni-Cs with lactic acid will enhance its properties. The presence of PAni-Cs was confirmed by observing its structure using Fourier transform infrared (FTIR) spectroscopy. The wettability of the films showed that films produced with lactic acid are less hydrophobic than those produced with acetic acid. Consequently, the computed surface energies revealed PAni-Cs films produced using lactic acid were higher. Water uptake of the films showed deviations when PAni and the solvents (lactic acid and acetic acid) were introduced. Furthermore, films produced with lactic acid were observed to be more flexible. These characterizations revealed that PAni-Cs produced with lactic acid are comparable to the properties of those produced with acetic acid showing that lactic acid helps in the improvement of PAni-Cs surface properties.

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