Quercetin inhibiting the PD ‐1/ PD‐L1 interaction for immune‐enhancing cancer chemopreventive agent

2021 ◽  
Author(s):  
Lei Jing ◽  
Jieru Lin ◽  
Yang Yang ◽  
Li Tao ◽  
Yuyin Li ◽  
...  
Keyword(s):  
Chemopreventive Agent

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

[6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process

2014 ◽  
Vol 14 (4) ◽  
pp. 313-321 ◽  
Author(s):  
Juliana Poltronieri ◽  
Amanda Becceneri ◽  
Angelina Fuzer ◽  
Julio Filho ◽  
Ana Martin ◽  
...  
Keyword(s):  
Chemopreventive Agent ◽  
Metastatic Process

scholarly journals Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers

2016 ◽  
Vol 68 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Hyun-Seuk Moon
Keyword(s):  
Risk Factor ◽  
Lipoic Acid ◽  
Octanoic Acid ◽  
Scattered Data ◽  
Alpha Lipoic Acid ◽  
Chemopreventive Agent ◽  
Anti Cancer ◽  
In Vivo Animal Models

Background: It has been generally accepted that being overweight or obese is a risk factor for several types of cancers, including breast, thyroid, colon, pancreatic and liver. In fact, people who are obese have more fat tissues that can produce hormones, such as insulin or estrogen, which may cause cancer cells to grow. Alpha lipoic acid (ALA) is anorganosulfur compound derived from octanoic acid, which is produced in animals normally, and is essential for aerobic metabolism. Summary: Studies in both in vitro cells and in vivo animal models have shown that ALA inhibits the initiation and promotion stages of carcinogenesis, suggesting that ALA has considerable attention as a chemopreventive agent. This brief review collects the scattered data available in the literature concerning ALA and highlights its anti-cancer properties, intermediary metabolism and exploratory implications. Key Messages: Based on scientific evidences so far, ALA might be useful agents in the management or chemoprevention of obesity-related cancers.

scholarly journals An Unprecedented High Content of the Bioactive Flavone Tricin in Huperzia Medicinal Species Used by the Saraguro in Ecuador

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100
Author(s):  
Chabaco Armijos ◽  
Jorge Ponce ◽  
Jorge Ramírez ◽  
Davide Gozzini ◽  
Paola Vita Finzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Traditional Medicine ◽  
Cell Lines ◽  
Cancer Cell ◽  
Potent Inhibitor ◽  
Community Living ◽  
Medicinal Species ◽  
Chemopreventive Agent ◽  
Southern Ecuador

The flavone tricin (5,7,4′-trihydroxy-3′,5′-dimethoxyflavone) is considered to be a selective potent inhibitor of different cancer cell lines and a potential colorectal cancer chemopreventive agent. In this paper we describe a reliable UHPLC-UV-ESIMS method for the determination of tricin in Huperzia plants used in the traditional medicine of the Saraguro community living in Southern Ecuador. An unusually high amount of tricin was found in H. brevifolia and H. compacta, which exceeded the content of this flavone determined so far in other plants.

scholarly journals The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

Oncogene ◽  
2003 ◽  
Vol 22 (40) ◽  
pp. 6220-6230 ◽  
Author(s):  
Patricia Boya ◽  
Maria Celia Morales ◽  
Rosa-Ana Gonzalez-Polo ◽  
Karine Andreau ◽  
Isabelle Gourdier ◽  
...  
Keyword(s):  
Mitochondrial Pathway ◽  
Chemopreventive Agent

scholarly journals Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors

2018 ◽  
Vol 435 ◽  
pp. 121-126 ◽  
Author(s):  
Eva Juengel ◽  
Holger H.H. Erb ◽  
Axel Haferkamp ◽  
Jochen Rutz ◽  
Felix K.-H. Chun ◽  
...  
Keyword(s):  
Hdac Inhibitor ◽  
Chemopreventive Agent

scholarly journals Characterization of a Stem-like Subpopulation in Basal-like Ductal Carcinoma in Situ (DCIS) Lesions

2013 ◽  
Vol 289 (3) ◽  
pp. 1303-1312 ◽  
Author(s):  
Qinglin Li ◽  
Gabriel Eades ◽  
Yuan Yao ◽  
Yongshu Zhang ◽  
Qun Zhou
Keyword(s):  
Cancer Cells ◽  
Aldehyde Dehydrogenase ◽  
Breast Cancer Cells ◽  
Ductal Carcinoma ◽  
Chemopreventive Agent ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression ◽  
Migration Potential

Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells. Here, we characterize stem-like subpopulations in a model of basal-like DCIS and identify subpopulations of CD49f+/CD24− stem-like cells that possess aldehyde dehydrogenase 1 activity. We found that these cells show enhanced migration potential compared with non-stem DCIS cells. We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation. Furthermore, we characterized exosomal trafficking of microRNAs in DCIS and found that several microRNAs (miRs) including miR-140, miR-29a, and miR-21 are differentially expressed in exosomes from DCIS stem-like cells. We found that SFN treatment could reprogram DCIS stem-like cells as evidenced by significant changes in exosomal secretion more closely resembling that of non-stem cancer cells. Finally, we demonstrated that exosomal secretion of miR-140 might impact signaling in nearby breast cancer cells.

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