Analysis of Water Solubility Data on the Basis of HYBOT Descriptors. Part 3. Solubility of Solid Neutral Chemicals and Drugs

2004 ◽  
Vol 23 (5) ◽  
pp. 327-343 ◽  
Author(s):  
Oleg A. Raevsky ◽  
Olga E. Raevskaja ◽  
Klaus-Jürgen Schaper
Keyword(s):  
Water Solubility ◽  
Solubility Data

Water Permeation through Elastomer Laminates, II. SBR/EPDM

1986 ◽  
Vol 59 (5) ◽  
pp. 779-786 ◽  
Author(s):  
Patrick E. Cassidy ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Temperature Dependence ◽  
Transport Mechanism ◽  
Water Solubility ◽  
Salt Water ◽  
Activation Energies ◽  
Permeation Rate ◽  
Solubility Data ◽  
Distilled Water ◽  
Arrhenius Behavior ◽  
Water Permeation

Abstract In summary, the measurements described here suggest that the temperature dependence of permeation rate had an Arrhenius behavior. Activation energies fall within the range expected for those membranes that follow activated transport mechanism. For all single elastomers, salt water exhibited higher permeation rates than did distilled water. The laminates show a directional behavior but more distinctly for distilled water than for salt water. Solubility data alone cannot, however, always account for this phenomenon.

Analysis of water solubility data on the basis of HYBOT descriptors

2003 ◽  
Vol 22 (9-10) ◽  
pp. 943-958 ◽  
Author(s):  
Klaus-J. Schaper ◽  
Brigitte Kunz ◽  
Oleg A. Raevsky
Keyword(s):  
Water Solubility ◽  
Solubility Data

scholarly journals Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures

2013 ◽  
Vol 17 ◽  
pp. 36-46 ◽  
Author(s):  
Shipra Baluja ◽  
Rahul Bhalodia ◽  
Mehul Bhatt ◽  
Nayan Vekariya ◽  
Ravi Gajera
Keyword(s):  
Thermodynamic Parameters ◽  
Atmospheric Pressure ◽  
Water Solubility ◽  
Chlorinated Solvents ◽  
Solubility Data ◽  
Heat Of Solution ◽  
Maximum Solubility ◽  
Carbon Tetra

The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb’s energy (ΔGsol), heat of solution (ΔHsol) and entropy of solution (ΔSsol) have also been evaluated.

scholarly journals Phase Equilibrium in 1-Butene–Water System and Correlation of Hydrocarbon-Water Solubility Data

1955 ◽  
Vol 47 (6) ◽  
pp. 1265-1271 ◽  
Author(s):  
Thomas W. Leland ◽  
John J. McKetta ◽  
Kenneth A. Kobe
Keyword(s):  
Phase Equilibrium ◽  
Water Solubility ◽  
Water System ◽  
Solubility Data

Analysis of water solubility data on the basis of HYBOT descriptors.

2003 ◽  
Vol 22 (9-10) ◽  
pp. 926-942 ◽  
Author(s):  
Oleg A. Raevsky ◽  
Klaus-J. Schaper
Keyword(s):  
Water Solubility ◽  
Solubility Data

ANALISIS FISIKA KIMIA DARI KERANG DARA (Anadara granosa) YANG BERASAL DARI KAYUTANYO KAB. BANGGAI The Analysis of physical chemical from dara shells (Anadara granosa) origin from Kayutanyo, Kab.Banggai

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
SULASMI ANGGO
Keyword(s):  
Protein Content ◽  
Water Content ◽  
Water Solubility ◽  
Gravimetric Method ◽  
Fat Content ◽  
Carbohydrate Content ◽  
Dust Content ◽  
Total Dust ◽  
Physical Chemical ◽  
Anadara Granosa

The Analysis of physical chemical from dara shells (Anadara granosa) origin from Kayutanyo, kab. Banggai, has been conducted.Dara shell meat is sleaned and dried and after that powered with blender. Determine % rendement, water bonding capacity and index water solubility with Anderson method, coarse fat content with gravimetric method and carbohydrate method with “bye difference” decrease method.The result of analysis showed rendement value is 24,35%, water bonding capacity is 1,6248 gram/ml, index water solubility is 0,202 gram/ml, water content is 79,0045%, total dust content is 1,072%, coarse protein content is 2,25%, coarse fat content is 8,47%, carbohydrate content is 9,2035%. Keyword : Dara shells, (Anadara granosa), analysis physical chemical

The solubility of calcium carbonate  in green liquor handling systems

TAPPI Journal ◽  
2019 ◽  
Vol 18 (10) ◽  
pp. 595-602
Author(s):  
ALISHA GIGLIO ◽  
VLADIMIROS G. PAPANGELAKIS ◽  
HONGHI TRAN
Keyword(s):  
Calcium Carbonate ◽  
Systematic Study ◽  
Kraft Pulp ◽  
Thermodynamic Simulation ◽  
Solubility Data ◽  
Pulp Mills ◽  
Persistent Problem ◽  
Green Liquor ◽  
Kraft Pulp Mills ◽  
Salt Systems

The formation of hard calcite (CaCO3) scale in green liquor handling systems is a persistent problem in many kraft pulp mills. CaCO3 precipitates when its concentration in the green liquor exceeds its solubility. While the solubility of CaCO3 in water is well known, it is not so in the highly alkaline green liquor environment. A systematic study was conducted to determine the solubility of CaCO3 in green liquor as a function of temperature, total titratable alkali (TTA), causticity, and sulfidity. The results show that the solubility increases with increased temperature, increased TTA, decreased causticity, and decreased sulfidity. The new solubility data was incorporated into OLI (a thermodynamic simulation program for aqueous salt systems) to generate a series of CaCO3 solubility curves for various green liquor conditions. The results help explain how calcite scale forms in green liquor handling systems.

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

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