Detection of high molecular weight starburst dendrimers by electrospray ionization mass spectometry

1995 ◽  
Vol 9 (15) ◽  
pp. 1552-1555 ◽  
Author(s):  
Brenda L. Schwartz ◽  
Alan L. Rockwood ◽  
Richard D. Smith ◽  
Donald A. Tomalia ◽  
Ralph Spindler
Keyword(s):  
Molecular Weight ◽  
Electrospray Ionization ◽  
High Molecular Weight ◽  
Ionization Mass ◽  
Mass Spectometry

A novel trityl/acridine derivatization agent for analysis of thiols by (matrix-assisted)(nanowire-assisted)laser desorption/ionization and electrospray ionization mass spectrometry

2017 ◽  
Vol 9 (45) ◽  
pp. 6335-6340 ◽  
Author(s):  
Artyom P. Topolyan ◽  
Maria A. Belyaeva ◽  
Mariya S. Slyundina ◽  
Valentina V. Ilyushenkova ◽  
Andrey A. Formanovsky ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Laser Desorption ◽  
Fixed Charge ◽  
Low Molecular Weight ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

A new agent was used for fixed-charge derivatization of low molecular weight thiols.

scholarly journals A straightforward electrospray ionization high resolution mass spectrometry method for underivatized long chain polysaccharides

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Roxana M. Ghiulai ◽  
Mirela Sarbu ◽  
Constantin Ilie ◽  
Alina D. Zamfir
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Electrospray Ionization ◽  
High Resolution Mass Spectrometry ◽  
Average Molecular Weight ◽  
Ionization Mass ◽  
Esi Ms ◽  
Singly Charged ◽  
Charged Ions ◽  
Long Chain

AbstractStructural analysis of long chain polysaccharides by electrospray ionization mass spectrometry (ESI-MS) is challenging since these molecules do not contain readily ionizable groups. Their mass spectra are dominated by singly charged ions, limiting the detection of high molecular weight species. Derivatization can enhance ionization, but analyte loss on purification decreases sensitivity. We report a method based on nanoESI-MS and MS/MS by collision induced dissociation (CID) for underivatized long chain polysaccharides. The procedure was tested on underivatized polydisperse dextrans (average molecular weight 4,000) at 2.6 kV ESI voltage and CID MS/MS at energies between 30-60 eV. 113 ions corresponding to species from Glc2 to Glc35 were detected. Ions at m/z 1,409.48, 1,107.35 and 1,438.47, assigned to [G17+2Na]2+,[G20+H+Na+K]3+ and [G35+2H+Na+K]4+, were sequenced and characterized by MS/MS. The component containing 35 Glc repeats is the longest polysaccharide chain detected by ESI-MS and structurally analyzed by MS/MS without prior derivatization and/or separation.

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