:
Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological
properties, which could play a major role in the common mechanisms associated with various disorders
like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural
modification of this scaffold could be helpful in the generation of new therapeutically useful
agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole,
there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic
prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole
derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological
activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives
has also been incorporated. The objective of the review is to provide insights to designing and
synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.