Polychlorinated Biphenyl-Induced Effects on Metabolic Enzymes, AP-1 Binding, Vitamin E, and Oxidative Stress in the Rat Liver

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.

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The protective effects of Δ9 -tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia

Journal of Pharmacy and Pharmacology ◽

10.1111/jphp.13042 ◽

2018 ◽

Vol 71 (3) ◽

pp. 408-416 ◽

Cited By ~ 1

Author(s):

Alisa Bahar Beydogan ◽

Zeynep Mine Coskun ◽

Sema Bolkent

Keyword(s):

Oxidative Stress ◽

Rat Liver ◽

Protective Effects ◽

And Oxidative Stress

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Role of vitamin E and oxidative stress in exercise

Nutrition ◽

10.1016/s0899-9007(01)00639-6 ◽

2001 ◽

Vol 17 (10) ◽

pp. 809-814 ◽

Cited By ~ 75

Author(s):

Jennifer M. Sacheck ◽

Jeffrey B. Blumberg

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

And Oxidative Stress

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The severity of rat liver injury by fructose and high fat depends on the degree of respiratory dysfunction and oxidative stress induced in mitochondria

Lipids in Health and Disease ◽

10.1186/s12944-019-1024-5 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 9

Author(s):

Claudia Isabel García-Berumen ◽

Omar Ortiz-Avila ◽

Manuel Alejandro Vargas-Vargas ◽

Bricia A. del Rosario-Tamayo ◽

Clotilde Guajardo-López ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Injury ◽

Rat Liver ◽

High Fat ◽

Respiratory Dysfunction ◽

And Oxidative Stress

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Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons

Medicina ◽

10.3390/medicina44050051 ◽

2008 ◽

Vol 44 (5) ◽

pp. 392 ◽

Cited By ~ 2

Author(s):

Liucija Černiauskienė ◽

Dalia Lukšienė ◽

Abdonas Tamošiūnas ◽

Regina Rėklaitienė ◽

Lilija Margevičienė

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Heart Disease ◽

Vitamin E ◽

Ischemic Heart Disease ◽

Odds Ratio ◽

Ischemic Heart ◽

Middle Aged ◽

Men And Women ◽

And Oxidative Stress

The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45–64 years). Material and methods. In this study, we have used data of 533 persons (247 men and 286 women) aged 45– 64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001–2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (≥5 mmol/L) and decreased level of lipid-standardized vitamin E (<20 mmol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods. Results. Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age. Conclusion. Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45–64-year-old persons.

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