A Cell-Type-Specific Transcription Enhancer of Type 16 Human Papillomavirus (HPV 16)-P97 Promoter Is Defined with HPV-Associated Cellular Events in Human Epithelial Cell Lines

Virology ◽  
1993 ◽  
Vol 195 (2) ◽  
pp. 500-510 ◽  
Author(s):  
Akiyoshi Taniguchi ◽  
Keiji Kikuchi ◽  
Kyosuke Nagata ◽  
Shigeru Yasumoto
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cell ◽  
Cell Lines ◽  
Cell Type ◽  
Human Epithelial Cell ◽  
Cellular Events ◽  
Epithelial Cell Lines ◽  
A Cell ◽  
Cell Type Specific ◽  
Transcription Enhancer

Infection of Human Epithelial Cell Lines by Epstein-Barr Virus

ORL ◽  
1984 ◽  
Vol 46 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Tom Takimoto ◽  
Kazuo Morishita ◽  
Ryozo Umeda ◽  
Hisashi Ogura ◽  
Motoichi Hatano
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Human Epithelial Cell ◽  
Barr Virus ◽  
Epithelial Cell Lines ◽  
Epstein Barr

Bcl-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines

1994 ◽  
Vol 107 (2) ◽  
pp. 363-371
Author(s):  
Q.L. Lu ◽  
A.M. Hanby ◽  
M.A. Nasser Hajibagheri ◽  
S.E. Gschmeissner ◽  
P.J. Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Lines ◽  
Cytoplasmic Localization ◽  
Human Epithelial Cell ◽  
Daughter Cells ◽  
Epithelial Cell Lines ◽  
Cell Immortalization

bcl-2 gene expression confers a survival advantage by preventing cells from entering apoptosis. In contrast to the previously described cytoplasmic localization of Bcl-2 in epithelial cells in vivo, in this study we have demonstrated, in a series of human epithelial cell lines, that Bcl-2 also localizes to mitotic nuclei. Both immunocytochemical and immunoelectron microscopical examinations localize this protein to nuclei and in particular to chromosomes. Nuclear Bcl-2 expression in these cell lines is correlated with the cell cycle. There is relatively strong expression during mitosis, most intense during prophase and metaphase, declining in telophase and then the protein becomes undetectable soon after separation of the two daughter cells. The expression and distribution of Bcl-2 is influenced by treatment with excessive thymidine. These results indicate that Bcl-2 may protect the cells from apoptosis occurring during mitosis and suggest a possible role for the protein in cell immortalization.

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