Effect of Losartan and Furosemide on the Urinary Excretion of Oxypurinol and Uric Acid

2006 ◽  
pp. 185-188 ◽  
Author(s):  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Zenta Tsutsumi ◽  
Toshikazu Hada
Keyword(s):  
Uric Acid ◽  
Urinary Excretion

Tests of Urinary Excretion of Uric Acid

1979 ◽  
Vol 91 (6) ◽  
pp. 925 ◽  
Author(s):  
STEPHEN M. SELTZER
Keyword(s):  
Uric Acid ◽  
Urinary Excretion

Basal urinary excretion of purine derivatives in sheep

1990 ◽  
Vol 1990 ◽  
pp. 109-109 ◽  
Author(s):  
J. Balcells ◽  
J.A. Guada ◽  
C. Castrillo ◽  
J.I. Bonafonte
Keyword(s):  
Uric Acid ◽  
Nucleic Acids ◽  
Urinary Excretion ◽  
Purine Derivatives ◽  
Exogenous Supply

In ruminants duodenal purines,mainly derived from microbial nucleic acids, are catabolised and excreted in the urine as xanthine, hypoxanthine, uric acid and allantoin. The use of purine derivatives as an index of net microbial syntesis in the rumen requires a better understanding of the contribution of endogenus losses to total urinary excretion.Similar levels of basal excretion of purine derivatives has been determined in ruminants maintained by intragastric nutrition (Giesecke et al. 1984, Fujihara et al. 1987) and preruminants fed on liquid diets (Linberg, 1989). However, lower excretion of allantoin and uric acid were recorded when exogenous supply was reduced by fasting (Rys et al. 1975).

Effects of Thermal Conditioning on Metabolic Responses of Rats to Altitude

1958 ◽  
Vol 195 (3) ◽  
pp. 735-738 ◽  
Author(s):  
Roy B. Mefferd ◽  
Henry B. Hale
Keyword(s):  
Weight Loss ◽  
Uric Acid ◽  
Urinary Excretion ◽  
Glutamic Acid ◽  
Strong Influence ◽  
Urine Volume ◽  
Barometric Pressure ◽  
Metabolic Responses ◽  
Different Temperatures ◽  
Per Se

The metabolic responses of rats acclimated to different temperatures (3°, 24° and 35°C) were compared during a 24-hour fasting exposure to low barometric pressure (380 mm Hg). Determinations included fasting weight loss, water intake, urine volume and urinary excretion of Na, K, Mg, Ca, PO4, urea, uric acid, creatinine, creatine, taurine, ß-alanine, glycine, α-alanine, valine + methionine, serine, threonine, tyrosine, glutamic acid, aspartic acid, lysine, arginine and histidine. Since the altitude tests were made at a neutral temperature (25°C) the altitude responses, per se, were determined by comparing the ground and altitude responses of each acclimated group at neutral temperatures. These comparisons revealed that the acclimated state of the rats exercised a strong influence on the altitude response for most of the variables. There were significant intergroup differences in this response for all variables except phosphate, urea, taurine, valine + methionine, serine, histidine and the Mg/Ca ratio.

Effects of somatotropin in rats acutely exposed to adverse environments

1961 ◽  
Vol 16 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Henry B. Hale ◽  
Roy B. Mefferd
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Barometric Pressure ◽  
Metabolic Effects ◽  
Subcutaneous Injections ◽  
Suggestive Evidence ◽  
Temperature And Pressure ◽  
Induced Changes ◽  
Neutral Conditions ◽  
Adverse Environments

Metabolic effects of acute (24-hr.) exposure to low barometric pressure (380 mm Hg), heat (35°C), or cold (2°C) were determined in fasting rats which had received subcutaneous injections of somatotropin (0.5 mg/100 gm b.wt.) 24 hours before and immediately before exposure. Comparison was made with rats exposed to the same conditions without pretreatment with somatotropin and with controls held under neutral conditions of temperature and pressure (24°C, 750 mm Hg). Somatotropin modified environmentally induced changes in 24-hour urinary excretion of urea, uric acid and phosphate and the urinary Na/K, Ca/P and uric acid/creatinine ratios. Suggestive evidence was thus obtained to support the hypothesis that somatotropin contributes to homeostasis. Submitted on October 26, 1959

scholarly journals Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid

2019 ◽  
Vol 3 (4) ◽  
pp. 448-460
Author(s):  
Erin B. Ware ◽  
Jennifer A. Smith ◽  
Wei Zhao ◽  
Ron T. Ganesvoort ◽  
Gary C. Curhan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Calcium Magnesium

Renal and salivary clearance of purine derivatives in sheep

1997 ◽  
Vol 65 (1) ◽  
pp. 83-91 ◽  
Author(s):  
J. C. Surra ◽  
J. A. Guada ◽  
J. Balcells ◽  
C. Castrillo
Keyword(s):  
Uric Acid ◽  
Plasma Concentration ◽  
Urinary Excretion ◽  
Buccal Cavity ◽  
Salivary Flow ◽  
Salivary Secretion ◽  
Purine Derivatives ◽  
Urinary Recovery ◽  
Fresh Matter ◽  
Saline Solutions

AbstractFour adult ewes (mean weight 42·6 kg) fitted with oesophageal fistulae were given 5 mmol/day ofallantoin or saline solutions by intrajugular continuous infusion. The experiment was a randomized cross-over design, with two consecutive 3-day infusion periods. One kg/day fresh matter of either chopped or pelleted fescue hay was distributed over 12 meals and salivary flow estimated from dilution of Co-EDTA infused into the buccal cavity. Allantoin infusion resulted in a rapid increase in its plasma concentration (84 to 128 (s.e. 1·5) μmol/l) and urinary excretion (9·6 to 13·3 (s.e. 0·18) mmol/day) without significant differences between diets. Salivary allantoin also increased (4·6 to 6·4 (s.e. 0·60) ymol/1) in response to infusion, although the concentration of total purine derivatives in saliva was only proportionately 0·08 that of plasma. Renal and salivary clearance of oxypurines, allantoin (78 (s.e. 5·0) ml/min and 13 (s.e. 0·7) ml/h), uric acid (466 (s.e. 98·0) ml/min and 45 (s.e. 9·8) ml/h) and creatinine (104 (s.e. 3·0) ml/min and 14 (s.e. 1·1) ml/h) were constant, irrespective of diet and infusion treatments. Urinary recovery of infused allantoin averaged 0·78 (s.e. 0·031) but salivary secretion, equivalent to about 0·003 of urinary losses, was not the explanation for the incomplete recovery.

Effect of amino acids on the plasma concentration and urinary excretion of uric acid and uridine

Metabolism ◽  
1999 ◽  
Vol 48 (8) ◽  
pp. 1023-1027 ◽  
Author(s):  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Zenta Tsutsumi ◽  
Hiroyuki Ohata ◽  
...  
Keyword(s):  
Amino Acids ◽  
Uric Acid ◽  
Plasma Concentration ◽  
Urinary Excretion

THE EFFECT OF LARGE DOSES OF THIOUREA ON THE COMPOSITION OF THE LIVER AND URINE OF RATS

1956 ◽  
Vol 13 (2) ◽  
pp. 141-149 ◽  
Author(s):  
F. DOLJANSKI ◽  
Z. ESHKOL ◽  
D. GIVOL ◽  
E. KAUFMANN ◽  
E. MARGOLIASH
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Ribonucleic Acid ◽  
Acid Content ◽  
Catalase Activity ◽  
Deoxyribonucleic Acid ◽  
Liver Weight ◽  
Liver Glycogen ◽  
Chemical Changes ◽  
Thiourea Treatment

SUMMARY Following the observation that large daily doses of thiourea induced numerous mitoses in the liver of rats [Rachmilewitz, Rosin & Doljanski, 1950], the concomitant chemical changes in the liver and urine of thiourea-treated rats were investigated. It was found that: (1) The mitogenetic reaction, which occurred on the 3rd day of treatment with the drug, was preceded by (a) a decrease in liver catalase activity to 30–50% of the normal within 12 hr; (b) an increase in total liver weight and concentration of liver ribonucleic acid within 2 days. The enlarged liver was normal with respect to protein, lipid, water and deoxyribonucleic acid content. (2) The concentration of liver glycogen decreased markedly on the 1st day of thiourea treatment but returned to normal by the 2nd or 3rd day. (3) During the period of treatment with thiourea there was an increase in the urinary excretion of uric acid, allantoin, and phosphate, as well as glucosuria and polyuria. There was no change in the excretion of urea and total sulphate. (4) All these changes, both in the liver and the urine, were fully reversible on withdrawing the drug.

THE EFFECT OF EPHEDRINE ON THE EXCRETION OF REDUCING STEROIDS, 17-KETOSTEROIDS AND URIC ACID IN HEALTHY MEN

1952 ◽  
Vol 8 (1) ◽  
pp. 27-31 ◽  
Author(s):  
BARBARA M. BRAY ◽  
W. H. H. MERIVALE ◽  
D. R. C. WILLCOX
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Inverse Relationship ◽  
Control Period ◽  
Acid Excretion ◽  
Normal Range ◽  
Healthy Men ◽  
Uric Acid Excretion ◽  
Upper Limit ◽  
Consistent Change

The urinary excretion in five healthy men of 17-ketosteroids, reducing steroids, uric acid and creatinine was studied for a 3-day control period, a period of 2 days during which 6 grains (390 mg.) of ephedrine were given by mouth, and for 1 day immediately thereafter. In all five men the excretion of reducing steroids rose to levels outside the normal range on one of the days on which ephedrine was given. There was an abrupt return to normal, even in the men who showed the increased excretion, on the first day of the administration of ephedrine. In two men 17-ketosteroid excretion rose above the upper limit of normal, but in two others there was no significant alteration, while in one the 17-ketosteroid excretion bore an inverse relationship to that of the reducing steroids. No consistent change occurred in the uric acid excretion.

Sign in / Sign up

Export Citation Format

Share Document