Analytical Use of Antibodies Based on Specific Molecular Binding

1987 ◽  
pp. 291-302
Author(s):  
A. Albertini ◽  
C. Iacobello ◽  
G. Ruggeri ◽  
P. Arosio
Keyword(s):  
Molecular Binding

Visualization of molecular binding sites at the nanoscale in the lift-up mode by amplitude-modulation atomic force microscopy

Nanoscale ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 4213-4220
Author(s):  
Tatsuhiro Maekawa ◽  
Takashi Nyu ◽  
Evan Angelo Quimada Mondarte ◽  
Hiroyuki Tahara ◽  
Kasinan Suthiwanich ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Molecular Recognition ◽  
Amplitude Modulation ◽  
Binding Sites ◽  
Local Distribution ◽  
New Approach ◽  
Molecular Binding ◽  
Force Microscopy ◽  
Atomic Force ◽  
Recognition Sites

We report a new approach to visualize the local distribution of molecular recognition sites with nanoscale resolution by amplitude-modulation atomic force microscopy.

scholarly journals The fundamental role of flexibility on the strength of molecular binding

Soft Matter ◽  
2012 ◽  
Vol 8 (23) ◽  
pp. 6385 ◽  
Author(s):  
Christopher Forrey ◽  
Jack F. Douglas ◽  
Michael K. Gilson
Keyword(s):  
Molecular Binding

Localized Collection of Airborne Analytes: A Transport Driven Approach to Improve the Response Time of Existing Gas Sensor Designs including SERS based Detection of Small Molecules

2015 ◽  
Vol 1746 ◽  
Author(s):  
Jun Fang ◽  
Se-Chul Park ◽  
Leslie Schlag ◽  
Thomas Stauden ◽  
Joerg Pezoldt ◽  
...  
Keyword(s):  
Response Time ◽  
Small Molecules ◽  
Gas Sensor ◽  
Recent Trend ◽  
Active Area ◽  
Analyte Concentration ◽  
Analyte Molecule ◽  
Collection Rate ◽  
Molecular Binding ◽  
Increased Sensitivity

ABSTRACTThe detection of single molecular binding events has been a recent trend in sensor research introducing various sensor designs where the active sensing elements are nanoscopic in size. Currently, diffusion-only-transport is often used and it becomes increasingly unlikely for an analyte molecule to “find” and interact with sensing structures where the active area is shrunk in size, trading an increased sensitivity with a long response time. This report introduces electrodynamic nanolens based analyte concentration concepts to transport airborne analytes to nanoscopic sensing points to improve the response time of existing gas sensor designs. In all cases we find that the collection rate is several orders of magnitudes higher than in the case where the collection is driven by diffusion.

scholarly journals Molecular binding in interacting quantum walks

2012 ◽  
Vol 14 (7) ◽  
pp. 073050 ◽  
Author(s):  
Andre Ahlbrecht ◽  
Andrea Alberti ◽  
Dieter Meschede ◽  
Volkher B Scholz ◽  
Albert H Werner ◽  
...  
Keyword(s):  
Quantum Walks ◽  
Molecular Binding

scholarly journals Molecular docking analysis of compounds from Justica adhatoda L with the MUC1 oncoprotein

2020 ◽  
Vol 16 (11) ◽  
pp. 937-941
Author(s):  
Ramajayam Govindan ◽  
Keyword(s):  
Molecular Docking ◽  
Drug Discovery ◽  
Docking Analysis ◽  
Molecular Binding ◽  
Different Types ◽  
Molecular Docking Analysis

The MUC1 oncoprotein is known to be linked with different types of cancer. Therefore, it is of interest to document the molecular docking analysis of compounds from Justica adhatoda L with the MUC1 oncoprotein. We report the structure based molecular binding features compounds such as amrinone, ethambutol, pyrazinamide and vasicoline the MUC1 oncoprotein for further consideration in drug discovery.

scholarly journals Possible Anti-viral effects of Neem (Azadirachta indica) on Dengue virus

2020 ◽  
Author(s):  
Vikas B Rao ◽  
Kalidas Yeturu
Keyword(s):  
Dengue Virus ◽  
Small Molecules ◽  
Azadirachta Indica ◽  
Antiviral Drug ◽  
Experimental Studies ◽  
Major Health ◽  
Molecular Binding ◽  
Scientific Curiosity ◽  
Mosquito Breeding ◽  
Health Complications

Dengue virus (DENV) has become a major health threat worldwide accounting for 50-100 million infections every year and keeping 2.5 billion people at a risk of the infection. Seriousness of the viral infection can be attributed to its lethality when not treated in time and potential to cause health complications post infection. Currently there are only preventive strategies and development of vaccination is still in its infancy of research. It is therefore highly necessary to discover newer drugs and therapies for this deadly virus. In this paper we report important insights we have obtained through a computational analysis of small molecules of Neem (Azadirachta indica) against dengue viral proteins and its required proteins in human. Our study involves identification of the effect of specific small molecules of Neem on proteins of human and virus corresponding to different pathways using simulated molecular binding analyses. We report here Gedunin and Pongamol contained in naturally occurring Neem as potential drugs against the Dengue virus.Significance StatementWe report important ligands in Neem that have potential antiviral activity against Dengue. Our selection of Neem for testing for antiviral properties has been inspired from Ayurveda. Due to unhygienic living conditions that facilitate mosquito breeding, Dengue is a major threat in developing countries causing millions of deaths. Despite the severity of the infection, no specific antiviral drug is available. The results obtained, in terms of newer potential ligands against Dengue are significant as this provides a basis for experimentally verifying and extending the same to develop a cure.We hope that this study would would spur scientific curiosity and undertaking of further elaborate experimental studies.

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