scholarly journals Normobaric Hyperoxia Does Not Change Optical Scattering or Pathlength but Does Increase Oxidised Cytochrome c Oxidase Concentration in Patients with Brain Injury

2012 ◽  
pp. 67-72 ◽  
Author(s):  
Arnab Ghosh ◽  
Ilias Tachtsidis ◽  
Christina Kolyva ◽  
David Highton ◽  
Clare Elwell ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Optical Scattering ◽  
Normobaric Hyperoxia

scholarly journals Hyperoxia results in increased aerobic metabolism following acute brain injury

2016 ◽  
Vol 37 (8) ◽  
pp. 2910-2920 ◽  
Author(s):  
Arnab Ghosh ◽  
David Highton ◽  
Christina Kolyva ◽  
Ilias Tachtsidis ◽  
Clare E Elwell ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Tissue Oxygenation ◽  
Cerebral Blood Flow Velocity ◽  
Oxygenation Index ◽  
Aerobic Metabolism ◽  
Acute Brain Injury ◽  
Cerebral Microdialysis ◽  
Terminal Electron Acceptor

Acute brain injury is associated with depressed aerobic metabolism. Below a critical mitochondrial pO2 cytochrome c oxidase, the terminal electron acceptor in the mitochondrial respiratory chain, fails to sustain oxidative phosphorylation. After acute brain injury, this ischaemic threshold might be shifted into apparently normal levels of tissue oxygenation. We investigated the oxygen dependency of aerobic metabolism in 16 acutely brain-injured patients using a 120-min normobaric hyperoxia challenge in the acute phase (24–72 h) post-injury and multimodal neuromonitoring, including transcranial Doppler ultrasound-measured cerebral blood flow velocity, cerebral microdialysis-derived lactate-pyruvate ratio (LPR), brain tissue pO2 (pbrO2), and tissue oxygenation index and cytochrome c oxidase oxidation state (oxCCO) measured using broadband spectroscopy. Increased inspired oxygen resulted in increased pbrO2 [ΔpbrO2 30.9 mmHg p < 0.001], reduced LPR [ΔLPR −3.07 p = 0.015], and increased cytochrome c oxidase (CCO) oxidation (Δ[oxCCO] + 0.32 µM p < 0.001) which persisted on return-to-baseline (Δ[oxCCO] + 0.22 µM, p < 0.01), accompanied by a 7.5% increase in estimated cerebral metabolic rate for oxygen ( p = 0.038). Our results are consistent with an improvement in cellular redox state, suggesting oxygen-limited metabolism above recognised ischaemic pbrO2 thresholds. Diffusion limitation or mitochondrial inhibition might explain these findings. Further investigation is warranted to establish optimal oxygenation to sustain aerobic metabolism after acute brain injury.

scholarly journals Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Ajay Rajaram ◽  
Daniel Milej ◽  
Marianne Suwalski ◽  
Lilian Kebaya ◽  
Matthew Kewin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Preterm Infants ◽  
Near Infrared ◽  
Correlation Spectroscopy ◽  
The Impact ◽  
The Brain

AbstractA major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a significant role in the etiology of preterm brain injury, with the first three days of life considered the period when the brain is most vulnerable. This study focused on monitoring cerebral perfusion and metabolism during the first 72 h after birth in preterm infants weighing less than 1500 g. Brain monitoring was performed by combining hyperspectral near-infrared spectroscopy to assess oxygen saturation and the oxidation state of cytochrome c oxidase (oxCCO), with diffuse correlation spectroscopy to monitor cerebral blood flow (CBF). In seven of eight patients, oxCCO remained independent of CBF, indicating adequate oxygen delivery despite any fluctuations in cerebral hemodynamics. In the remaining infant, a significant correlation between CBF and oxCCO was found during the monitoring periods on days 1 and 3. This infant also had the lowest baseline CBF, suggesting the impact of CBF instabilities on metabolism depends on the level of blood supply to the brain. In summary, this study demonstrated for the first time how continuous perfusion and metabolic monitoring can be achieved, opening the possibility to investigate if CBF/oxCCO monitoring could help identify preterm infants at risk of brain injury.

Cognitive improvement of mice induced by exercise prior to traumatic brain injury is associated with cytochrome c oxidase

2014 ◽  
Vol 570 ◽  
pp. 86-91 ◽  
Author(s):  
Ying li Gu ◽  
Li wei Zhang ◽  
Ning Ma ◽  
Lin lin Ye ◽  
De xin Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Cognitive Improvement

Relationship Between Cerebral Cytochrome-C-Oxidase and Oxygenation is Associated with Brain Injury Severity in Birth Asphyxiated Infants

2016 ◽  
Author(s):  
Gemma Bale ◽  
Subhabrata Mitra ◽  
Judith Meek ◽  
Nicola Robertson ◽  
Ilias Tachtsidis
Keyword(s):  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Injury Severity

scholarly journals A new broadband near-infrared spectroscopy system for in-vivo measurements of cerebral cytochrome-c-oxidase changes in neonatal brain injury

2014 ◽  
Vol 5 (10) ◽  
pp. 3450 ◽  
Author(s):  
Gemma Bale ◽  
Subhabrata Mitra ◽  
Judith Meek ◽  
Nicola Robertson ◽  
Ilias Tachtsidis
Keyword(s):  
Infrared Spectroscopy ◽  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Spectroscopy System

Traumatic Brain Injury-Induced Changes in Gene Expression and Functional Activity of Mitochondrial Cytochrome C Oxidase

2001 ◽  
Vol 18 (10) ◽  
pp. 993-1009 ◽  
Author(s):  
L.K. Harris ◽  
R.T. Black ◽  
K.M. Golden ◽  
T.M. Reeves ◽  
J.T. Povlishock ◽  
...  
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Functional Activity ◽  
Mitochondrial Cytochrome ◽  
Induced Changes ◽  
Mitochondrial Cytochrome C

scholarly journals Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea

2011 ◽  
pp. 9-14 ◽  
Author(s):  
Ilias Tachtsidis ◽  
Martin M. Tisdall ◽  
Caroline Pritchard ◽  
Terence S. Leung ◽  
Arnab Ghosh ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Brain Tissue
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