Solute Carriers

2013 ◽  
pp. 401-442
Author(s):  
Richard H. Ho ◽  
Richard B. Kim
Keyword(s):  
Solute Carriers

Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics

MedChemComm ◽  
2016 ◽  
Vol 7 (8) ◽  
pp. 1462-1478 ◽  
Author(s):  
Margarida Estudante ◽  
Graça Soveral ◽  
José G. Morais ◽  
Leslie Z. Benet
Keyword(s):  
Drug Toxicity ◽  
Physiological Functions ◽  
Solute Carriers ◽  
Exogenous Compounds

SLCs transport many endogenous and exogenous compounds including drugs; SLCs dysfunction has implications in pharmacokinetics, drug toxicity or lack of efficacy.

scholarly journals Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression

Open Biology ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 170142 ◽  
Author(s):  
Emelie Perland ◽  
Sonchita Bagchi ◽  
Axel Klaesson ◽  
Robert Fredriksson
Keyword(s):  
Lipid Bilayers ◽  
Markov Models ◽  
Phylogenetic Analyses ◽  
Molecular Transport ◽  
Major Facilitator Superfamily ◽  
Proximity Ligation Assay ◽  
Sequence Comparisons ◽  
Altered Expression ◽  
Solute Carriers ◽  
Major Facilitator

Solute carriers (SLCs) are vital as they are responsible for a major part of the molecular transport over lipid bilayers. At present, there are 430 identified SLCs, of which 28 are called atypical SLCs of major facilitator superfamily (MFS) type. These are MFSD1, 2A, 2B, 3, 4A, 4B, 5, 6, 6 L, 7, 8, 9, 10, 11, 12, 13A, 14A and 14B; SV2A, SV2B and SV2C; SVOP and SVOPL; SPNS1, SPNS2 and SPNS3; and UNC93A and UNC93B1. We studied their fundamental properties, and we also included CLN3, an atypical SLC not yet belonging to any protein family (Pfam) clan, because its involvement in the same neuronal degenerative disorders as MFSD8. With phylogenetic analyses and bioinformatic sequence comparisons, the proteins were divided into 15 families, denoted atypical MFS transporter families (AMTF1-15). Hidden Markov models were used to identify orthologues from human to Drosophila melanogaster and Caenorhabditis elegans . Topology predictions revealed 12 transmembrane segments (for all except CLN3), corresponding to the common MFS structure. With single-cell RNA sequencing and in situ proximity ligation assay on brain cells, co-expressions of several atypical SLCs were identified. Finally, the transcription levels of all genes were analysed in the hypothalamic N25/2 cell line after complete amino acid starvation, showing altered expression levels for several atypical SLCs.

scholarly journals Energetic Evolution of Cellular Transportomes

2017 ◽  
Author(s):  
Behrooz Darbani ◽  
Douglas B. Kell ◽  
Irina Borodina
Keyword(s):  
Ion Channels ◽  
Bacterial Species ◽  
Living Cells ◽  
Energetic Efficiency ◽  
Cellular Functions ◽  
Transporter Proteins ◽  
Genome Wide Analysis ◽  
Solute Carriers ◽  
Genome Wide ◽  
A Genome

ABSTRACTTransporter proteins mediate the translocation of substances across the membranes of living cells. We performed a genome-wide analysis of the compositional reshaping of cellular transporters (the transportome) across the kingdoms of bacteria, archaea, and eukarya. We show that the transportomes of eukaryotes evolved strongly towards a higher energetic efficiency, as ATP-dependent transporters diminished and secondary transporters and ion channels proliferated. This change has likely been important in the development of tissues performing energetically costly cellular functions. The transportome analysis also indicated seven bacterial species, includingNeorickettsia risticiiandNeorickettsia sennetsu, as likely origins of the mitochondrion in eukaryotes, due to the restricted presence therein of clear homologues of modern mitochondrial solute carriers.

Solute carriers involved in energy transfer of mitochondria form a homologous protein family

FEBS Letters ◽  
1987 ◽  
Vol 212 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Heinrich Aquila ◽  
Thomas A. Link ◽  
Martin Klingenberg
Keyword(s):  
Energy Transfer ◽  
Protein Family ◽  
Homologous Protein ◽  
Solute Carriers

scholarly journals Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters

FEBS Letters ◽  
2020 ◽  
Author(s):  
Ludwik Gorczyca ◽  
Jianyao Du ◽  
Kristin M. Bircsak ◽  
Xia Wen ◽  
Anna M. Vetrano ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Abc Transporters ◽  
Low Oxygen ◽  
Solute Carriers ◽  
Low Oxygen Tension

Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology

2020 ◽  
Author(s):  
Stephen J. Fairweather ◽  
Nishank Shah ◽  
Stefan Brӧer
Keyword(s):  
Function Structure ◽  
Solute Carriers

scholarly journals The combined expression of solute carriers is associated with a poor prognosis in highly proliferative ER+ breast cancer

2019 ◽  
Vol 175 (1) ◽  
pp. 27-38 ◽  
Author(s):  
Rokaya El-Ansari ◽  
Madeleine L. Craze ◽  
Lutfi Alfarsi ◽  
Daniele Soria ◽  
Maria Diez-Rodriguez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Poor Prognosis ◽  
Solute Carriers
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