Gene Therapy Strategies to Augment Contractile Function in Heart Failure

2001 ◽  
pp. 181-199
Author(s):  
Michael J. Davidson ◽  
Walter J. Koch
Keyword(s):  
Heart Failure ◽  
Gene Therapy ◽  
Contractile Function ◽  
Therapy Strategies

scholarly journals Recent advances in cardiac gene therapy strategies targeting advanced heart failure

2017 ◽  
Vol 3 (4) ◽  
pp. 163-169 ◽  
Author(s):  
C. Chen ◽  
T. Seeger ◽  
V. Termglinchan ◽  
I. Karakikes
Keyword(s):  
Heart Failure ◽  
Gene Therapy ◽  
Advanced Heart Failure ◽  
Recent Advances ◽  
Cardiac Gene ◽  
Therapy Strategies

Gene Therapy Strategies in Prostate Cancer

2005 ◽  
Vol 5 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Iris Eder ◽  
Petra Haag ◽  
Georg Bartsch ◽  
Helmut Klocker
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Therapy Strategies

scholarly journals Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art

2021 ◽  
Author(s):  
Aida Nourbakhsh ◽  
Brett M. Colbert ◽  
Eric Nisenbaum ◽  
Aziz El-Amraoui ◽  
Derek M. Dykxhoorn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Hearing Loss ◽  
Treatment Modalities ◽  
Versus Gene ◽  
Vitro Model ◽  
New Treatment ◽  
Induced Pluripotent ◽  
Therapy Strategies

AbstractProgressive non-syndromic sensorineural hearing loss (PNSHL) is the most common cause of sensory impairment, affecting more than a third of individuals over the age of 65. PNSHL includes noise-induced hearing loss (NIHL) and inherited forms of deafness, among which is delayed-onset autosomal dominant hearing loss (AD PNSHL). PNSHL is a prime candidate for genetic therapies due to the fact that PNSHL has been studied extensively, and there is a potentially wide window between identification of the disorder and the onset of hearing loss. Several gene therapy strategies exist that show potential for targeting PNSHL, including viral and non-viral approaches, and gene editing versus gene-modulating approaches. To fully explore the potential of these therapy strategies, a faithful in vitro model of the human inner ear is needed. Such models may come from induced pluripotent stem cells (iPSCs). The development of new treatment modalities by combining iPSC modeling with novel and innovative gene therapy approaches will pave the way for future applications leading to improved quality of life for many affected individuals and their families.

scholarly journals Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions

2021 ◽  
Vol 20 ◽  
pp. 483-496
Author(s):  
Mitchel J.R. Ruigrok ◽  
Henderik W. Frijlink ◽  
Barbro N. Melgert ◽  
Peter Olinga ◽  
Wouter L.J. Hinrichs
Keyword(s):  
Gene Therapy ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Future Directions ◽  
Recent Advances ◽  
Therapy Strategies

scholarly journals AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome

2020 ◽  
Vol 126 (8) ◽  
pp. 1024-1039 ◽  
Author(s):  
Suya Wang ◽  
Yifei Li ◽  
Yang Xu ◽  
Qing Ma ◽  
Zhiqiang Lin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gene Therapy ◽  
Barth Syndrome ◽  
Knockout Model

scholarly journals Evidence of an endothelin-1 autocrine loop in cardiac myocytes: Relation to contractile function with congestive heart failure

1996 ◽  
Vol 27 (2) ◽  
pp. 56
Author(s):  
Patrick B. Thomas ◽  
Eddie C.K. Liu ◽  
Maria L. Webb ◽  
Rupak Mukherjee ◽  
Francis G. Spinale
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Myocytes ◽  
Contractile Function ◽  
Autocrine Loop ◽  
Endothelin 1

Regulatory considerations for gene-therapy strategies and products

1993 ◽  
Vol 11 (5) ◽  
pp. 189-191 ◽  
Author(s):  
Nelson A. Wivel
Keyword(s):  
Gene Therapy ◽  
Therapy Strategies
Sign in / Sign up

Export Citation Format

Share Document