Phase Wave and Perception of Amoeboid Cells

1989 ◽  
pp. 223-230
Author(s):  
Yonosuke Kobatake ◽  
Tetsuo Ueda ◽  
Kenji Matsumoto
Keyword(s):  
Phase Wave ◽  
Amoeboid Cells

scholarly journals III. On the coalescence of amœboid cells into plasmodia, and on the so-called coagulation of invertebrate fluids

1880 ◽  
Vol 30 (200-205) ◽  
pp. 252-255 ◽  
Keyword(s):  
Cover Glass ◽  
Superficial Resemblance ◽  
Glass Cell ◽  
Amoeboid Cells

Whether one collects the perivisceral fluid of a sea-urehin or of a worm, or the blood of a crustacean or a mollusc, the same phenomenon is always more or less distinctly to be observed. A kind of coagulation takes place, the fluid separating sooner or later into two portions, which have considerable superficial resemblance to the clot and serum of vertebrate blood. It is easy to watch the formation of the clot by placing a drop of fresh-drawn fluid upon a cover-glass and inverting this above a glass cell, of which the edge is oiled to prevent evaporation. The drop thus hangs freely and the coagulation can go on without interference.

A Min-Max Based Hyperparameter Estimation For Domain-Adapted Segmentation Of Amoeboid Cells

2021 ◽  
Author(s):  
Suvadip Mukherjee ◽  
Rituparna Sarkar ◽  
Elisabeth Labruyere ◽  
Jean-Christophe Olivo-Marin
Keyword(s):  
Hyperparameter Estimation ◽  
Amoeboid Cells

scholarly journals Correction to: Application of Multichannel Analysis of Surface Waves to S-Phase Wave Anisotropy Estimation

2018 ◽  
Vol 66 (6) ◽  
pp. 1525-1525
Author(s):  
Iwona Stan-Kłeczek ◽  
Maciej J. Mendecki
Keyword(s):  
Surface Waves ◽  
S Phase ◽  
Phase Wave ◽  
Multichannel Analysis

scholarly journals RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis

2021 ◽  
Author(s):  
Maria Laura Tognoli ◽  
Nikola Vlahov ◽  
Sander Steenbeek ◽  
Anna M. Grawenda ◽  
Michael Eyres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Metastasis ◽  
Early Stage ◽  
Methylation Status ◽  
Target Cells ◽  
Stem Cell Markers ◽  
Breast Cancer Patients ◽  
Actomyosin Contractility ◽  
Amoeboid Cells

AbstractCell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells are similarly associated with metastasis, but how these populations arise in tumors is not fully understood. Here we show that the novel oncogene RASSF1C drives mesenchymal to amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activates Rho/ROCK via SRC mediated RhoGDI inhibition, resulting in generation of actomyosin contractility. Moreover, we demonstrate that amoeboid cells display the cancer stem cell markers CD133, ALDH1 and the pluripotent marker Nanog; are accompanied by higher invasive potential in vitro and in vivo; and employ extracellular vesicles to transfer the invasive phenotype to target cells and tissue. Importantly, the underlying RASSF1C driven biological processes concur to explain clinical data: namely, methylation of the RASSF1C promoter correlates with better survival in early stage breast cancer patients. Therefore, we propose the use of RASSF1 gene promoter methylation status as a biomarker for patient stratification.

scholarly journals Three Dimensional Traction Forces Exerted by Migrating Amoeboid Cells

2012 ◽  
Vol 102 (3) ◽  
pp. 704a
Author(s):  
Begona Alvarez-Gonzalez ◽  
Juan C. del Alamo ◽  
Ruedi Meili ◽  
Baldomero Alonso-Latorre ◽  
Richard Firtel ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Traction Forces ◽  
Amoeboid Cells

Memoirs: The Reproductive System of the Planarian Artioposthia Triangulata (Dendy)

1937 ◽  
Vol s2-80 (317) ◽  
pp. 99-125
Author(s):  
MARION L. FYFE
Keyword(s):  
Seminal Vesicle ◽  
Reproductive System ◽  
Vas Deferens ◽  
Reproductive Organs ◽  
Internal Opening ◽  
Main Subject ◽  
The Brain ◽  
Amoeboid Cells

The main subject of this paper is a detailed description of the reproductive organs of a planarian initially described by Dendy as Geoplana triangulata. Five unusual features are observed in the reproductive system: 1. The vas deferens consists of a series of wide convoluted branching tubes extending from the region of the mouth to the anterior end of the seminal vesicle. 2. The penis is very small and inconspicuous. 3. The atrium masculinum is provided with three pairs of muscular gland-organs or adenodactyli. 4. The paired ovaries are situated one on each side of the seminal vesicle, not in the region of the brain as is usual. 5. Each ovary is a long fusiform body enclosing more than one true ovary or germarium, as well as specialized parovarian and amoeboid cells which are probably nutritive, and are associated with the internal opening of the oviduct. The writer refers Geoplana triangulata Dendy to the genus Artioposthia owing to the presence of adenodactyli in the atrium masculinum. Each adenodactylus encloses a glandular reservoir from which a ciliated duct leads to the atrial cavity. The actual function of the adenodactyli is obscure, but the very small size of the penis and the fact that the adenodactyli are extrusible suggests the possibility of these latter performing the function of a penis.

Biological factors affecting enflagellation of Naegleria fowleri

1982 ◽  
Vol 152 (2) ◽  
pp. 803-808
Author(s):  
T W Woodworth ◽  
D T John ◽  
S G Bradley
Keyword(s):  
Population Density ◽  
Stationary Phase ◽  
Culture Medium ◽  
Actinomycin D ◽  
Suitable Model ◽  
Naegleria Fowleri ◽  
Biological Factors ◽  
Factors Affecting ◽  
Nægleria Fowleri ◽  
Amoeboid Cells

Naegleria fowleri is a pathogenic amoeboflagellate that can be evoked to transform from amoebae to flagellates by subculture to nonnutrient buffer. More than half of the amoebae of strains KUL, nN68, and Lovell became enflagellated 300 min after subculture to amoeba-saline, whereas no amoebae of strains NF66, NF69, and HB4 did. N. fowleri nN68 enflagellated best when grown at 32 or 37 degrees C and subcultured to amoeba-saline at 37 or 42 degrees C. Amoebae from the stationary phase of growth enflagellated more readily than did actively growing amoebae. Incubation in expended culture medium from stationary-phase cultures enhanced the capability of growing amoebae to enflagellate after subculture to amoebasaline. Enflagellation was more extensive when the population density in amoebasaline did not exceed 2 x 10(5) amoebae per ml. Cycloheximide at 1 microgram/ml and actinomycin D at 25 micrograms/ml inhibited growth of N. fowleri nN68. Cycloheximide at 0.5 microgram/ml and actinomycin D at 25 micrograms/ml completely prevented enflagellation when added at time zero. Cycloheximide at 0.5 microgram/ml, added 120 to 300 min after initiation of enflagellation, prevented further differentiation and caused existing flagellates to revert to amoeboid cells. Similarly, actinomycin D at 25 micrograms/ml, added 90 to 300 min after initiation of enflagellation, retarded differentiation and caused flagellates to revert. Radiolabeled precursors were incorporated into macromolecules during differentiation in nonnutrient buffer. Enflagellation of N. fowleri is a suitable model for studying regulation of a eucaryotic protist.

scholarly journals Lymphocytes perform reverse adhesive haptotaxis mediated by LFA-1 integrins

2020 ◽  
Vol 133 (16) ◽  
pp. jcs242883
Author(s):  
Xuan Luo ◽  
Valentine Seveau de Noray ◽  
Laurene Aoun ◽  
Martine Biarnes-Pelicot ◽  
Pierre-Olivier Strale ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lymph Nodes ◽  
Adhesion Molecules ◽  
Stromal Cells ◽  
Mesenchymal Cells ◽  
High Endothelial Venules ◽  
Integrin Ligands ◽  
Inflamed Tissue ◽  
Amoeboid Cells

ABSTRACTCell guidance by anchored molecules, or haptotaxis, is crucial in development, immunology and cancer. Adhesive haptotaxis, or guidance by adhesion molecules, is well established for mesenchymal cells such as fibroblasts, whereas its existence remains unreported for amoeboid cells that require less or no adhesion in order to migrate. We show that, in vitro, amoeboid human T lymphocytes develop adhesive haptotaxis mediated by densities of integrin ligands expressed by high endothelial venules. Moreover, lymphocytes orient towards increasing adhesion with VLA-4 integrins (also known as integrin α4β1), like all mesenchymal cells, but towards decreasing adhesion with LFA-1 integrins (also known as integrin αLβ4), which has not previously been observed. This counterintuitive ‘reverse haptotaxis’ cannot be explained by existing mechanisms of mesenchymal haptotaxis involving either competitive anchoring of cell edges under tension or differential integrin-activated growth of lamellipodia, because they both favor orientation towards increasing adhesion. The mechanisms and functions of amoeboid adhesive haptotaxis remain unclear; however, multidirectional integrin-mediated haptotaxis might operate around transmigration ports on endothelia, stromal cells in lymph nodes, and inflamed tissue where integrin ligands are spatially modulated.

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