Characterization of LH/hCG Receptor Binding Inhibitor in Corpora Lutea of Human and Sheep Ovaries

1982 ◽  
pp. 283-301 ◽  
Author(s):  
G. L. Kumari ◽  
Narender Kumar ◽  
S. Duraiswami ◽  
J. K. Datta ◽  
I. C. Vidyasagar ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Corpora Lutea ◽  
Hcg Receptor

scholarly journals Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Thomas A. Johnson ◽  
Ville Paakinaho ◽  
Sohyoung Kim ◽  
Gordon L. Hager ◽  
Diego M. Presman
Keyword(s):  
Receptor Binding ◽  
Site Response ◽  
Physiological Role ◽  
Binding Potential ◽  
Open Chromatin ◽  
Imaging Data ◽  
Response Elements ◽  
Genome Wide ◽  
Genomic Studies

AbstractA widely regarded model for glucocorticoid receptor (GR) action postulates that dimeric binding to DNA regulates unfavorable metabolic pathways while monomeric receptor binding promotes repressive gene responses related to its anti-inflammatory effects. This model has been built upon the characterization of the GRdim mutant, reported to be incapable of DNA binding and dimerization. Although quantitative live-cell imaging data shows GRdim as mostly dimeric, genomic studies based on recovery of enriched half-site response elements suggest monomeric engagement on DNA. Here, we perform genome-wide studies on GRdim and a constitutively monomeric mutant. Our results show that impairing dimerization affects binding even to open chromatin. We also find that GRdim does not exclusively bind half-response elements. Our results do not support a physiological role for monomeric GR and are consistent with a common mode of receptor binding via higher order structures that drives both the activating and repressive actions of glucocorticoids.

Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice

2006 ◽  
Vol 529 (1-3) ◽  
pp. 157-163 ◽  
Author(s):  
Tomomi Oki ◽  
Shuji Maruyama ◽  
Yukiko Takagi ◽  
Henry I. Yamamura ◽  
Shizuo Yamada
Keyword(s):  
Oral Administration ◽  
Muscarinic Receptor ◽  
Receptor Binding

Characterization of peripheral blood acetylcholine receptor-binding B cells in experimental myasthenia gravis

2011 ◽  
Vol 271 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Windy Allman ◽  
Shamsher S. Saini ◽  
Erdem Tuzun ◽  
Premkumar Christadoss
Keyword(s):  
B Cells ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Binding ◽  
Peripheral Blood
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