External Control of a Shift in Antibody Synthesis

Author(s):  
S. Hinchman ◽  
J. R. Battisto
Author(s):  
P. Hagemann

The use of computers in the analytical electron microscopy today shows three different trends (1) automated image analysis with dedicated computer systems, (2) instrument control by microprocessors and (3) data acquisition and processing e.g. X-ray or EEL Spectroscopy.While image analysis in the T.E.M. usually needs a television chain to get a sequential transmission suitable as computer input, the STEM system already has this necessary facility. For the EM400T-STEM system therefore an interface was developed, that allows external control of the beam deflection in TEM as well as the control of the STEM probe and video signal/beam brightness on the STEM screen.The interface sends and receives analogue signals so that the transmission rate is determined by the convertors in the actual computer periphery.


2010 ◽  
Vol 69 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Samantha Perrin ◽  
Benoît Testé

Research into the norm of internality ( Beauvois & Dubois, 1988 ) has shown that the expression of internal causal explanations is socially valued in social judgment. However, the value attributed to different types of internal explanations (e.g., efforts vs. traits) is far from homogeneous. This study used the Weiner (1979 ) tridimensional model to clarify the factors explaining the social utility attached to internal versus external explanations. Three dimensions were manipulated: locus of causality, controllability, and stability. Participants (N = 180 students) read the explanations expressed by appliants during a job interview. They then described the applicants on the French version of the revised causal dimension scale and rated their future professional success. Results indicated that internal-controllable explanations were the most valued. In addition, perceived internal and external control of explanations were significant predictors of judgments.


2007 ◽  
pp. 4-10 ◽  
Author(s):  
G. Satarov

Two aspects of the problem of corruption are discussed in the article. The first one concerns the evaluation of the level of corruption. The method of measuring the size of business corruption market is described. The specifics of its estimation as well as its relation with the main macroeconomic indexes are discussed. The second aspect regards the strategies of corruption reduction. The importance of establishing external control over the bureaucracy is noted. The failure of institutions transplantation as the main method of economic transformations is pointed out. The gaps in social knowledge are discussed, which decrease effectiveness of institutional borrowings.


1997 ◽  
Vol 3 (3-4) ◽  
pp. 50-53
Author(s):  
O.D. Fedorovskyi ◽  
◽  
V.I. Kononov ◽  
K.Yu. Sukhanov ◽  
◽  
...  

Author(s):  
L.G. Khludova ◽  
I.A. Manto ◽  
E.A. Latysheva ◽  
T.V. Latysheva ◽  
M.R. Khaitov

Актуальность. Заместительная терапия иммуноглобулинами человека является ведущим патогенетическим методом лечения первичных иммунодефицитов с нарушением синтеза антител. В настоящее время в России доступно несколько препаратов иммуноглобулинов человека нормальных для внутривенного введения. Цель. Оценить эффективность и безопасность препарата Привиджен (10 раствор иммуноглобулина для внутривенного введения) в реальной клинической практике в течение 12 клинических месяцев. Материалы и методы. 20 взрослых с диагнозом общая вариабельная иммунная недостаточности и Х-сцепленная агаммаглобулинемия получали внутривенный иммуноглобулин Привиджен к интервалом 243 дня в течение 12 мес. Первичными критериями оценки была частота инфекционных осложнений и нежелательных явлений. Результаты. У большинства пациентов в ходе исследования достигнут удовлетворительный претранс-фузионный уровень IgG. Тяжелых нежелательных явлений, связанных с введением препарата, не зарегистрировано. Заключение. В ходе исследования препарат продемонстрировал высокую эффективность и безопасность у пациентов, нуждающихся в ежемесячной заместительной терапииRelevance. Replacement therapy with human immunoglobulins is the leading pathogenetic method of treatment of primary immunodeficiency with impaired antibody synthesis. Currently, several preparations of human immunoglobulins for intravenous administration are available in Russia. Purposes. Evaluation of the efficacy and safety of Privigen immunoglobulin intravenous 10 liquid in real clinical practice within 12 clinical months. Methods. Twenty adults diagnosed with common variable immunodeficiency or X-linked agammaglobulinemia received intravenous Privigen infusions (0.2-0.4 mg/kg) at 243 intervals over a 12-month period. The primary endpoint was the annual rate of infections and adverse events. Results. Sufficient level of IgG was achieved in most patients during the study. Severe adverse reactions during the treatment were not registered. Conclusions. High efficacy and safety of monthly replacement therapy in patients with primary immunodeficiency with impaired antibody synthesis has been demonstrated.


Author(s):  
José Capmany ◽  
Daniel Pérez

Programmable Integrated Photonics (PIP) is a new paradigm that aims at designing common integrated optical hardware configurations, which by suitable programming can implement a variety of functionalities that, in turn, can be exploited as basic operations in many application fields. Programmability enables by means of external control signals both chip reconfiguration for multifunction operation as well as chip stabilization against non-ideal operation due to fluctuations in environmental conditions and fabrication errors. Programming also allows activating parts of the chip, which are not essential for the implementation of a given functionality but can be of help in reducing noise levels through the diversion of undesired reflections. After some years where the Application Specific Photonic Integrated Circuit (ASPIC) paradigm has completely dominated the field of integrated optics, there is an increasing interest in PIP justified by the surge of a number of emerging applications that are and will be calling for true flexibility, reconfigurability as well as low-cost, compact and low-power consuming devices. This book aims to provide a comprehensive introduction to this emergent field covering aspects that range from the basic aspects of technologies and building photonic component blocks to the design alternatives and principles of complex programmable photonics circuits, their limiting factors, techniques for characterization and performance monitoring/control and their salient applications both in the classical as well as in the quantum information fields. The book concentrates and focuses mainly on the distinctive features of programmable photonics as compared to more traditional ASPIC approaches.


1981 ◽  
Vol 15 (1) ◽  
pp. 43-48
Author(s):  
Dick R. Gourley ◽  
David E. Kapel ◽  
John W. Hill

The locus of control dimensions among senior Pharm.D. students electing post-Pharm.D. residencies (N=15) are compared with first (N = 60) and second year (N = 55) Pharm.D. students, as well as with senior Pharm.D. students not electing residencies (N=14). Volunteer clinical faculty [hospital (N=27) and community (N = 23) pharmacy preceptors] and full-time clinical faculty (N = 22) are also compared. The Reid-Ware three-factor internal-external scale was completed by the study population. The dimensions measured were: self-control, social systems control, and fatalism. This study was undertaken to: 1. compare the locus of control dimensions among senior pharmacy students electing post-Pharm.D. residencies with senior pharmacy students not electing post-Pharm.D. residencies (and with other pharmacy students) and 2. compare the locus of control dimensions among senior pharmacy students electing and not electing post-Pharm. D. residencies (and with other pharmacy students) with their clinical, hospital, and community faculty to identify personality congruence (i.e., similarities, differences) which might facilitate the development of patient oriented-interactive behaviors necessary for clinical practice. Self-control (SC) was the major factor that generated the significant difference in the seven groups. The clinical (full-time) faculty group is significantly different from the student groups with the exception of the P-3, residency students. Over 50 percent of the P-3 residency group responded more like the faculty groups than like other students, with more P-3 residency students responding like clinical faculty than any other student or faculty group. The implication is that a similar personality profile exists in terms of internal/external control for the P-3 residency and full-time clinical faculty groups. Professors may have influenced, stimulated, or motivated those students most like themselves to enter a residency program. Based on the data, it would appear desirable to profile pharmacy students and give those who have a strong internal self-control factor encouragement to pursue post-graduate academic or residency programs and to retain as many of those individuals as possible in the areas of pharmacy that directly influence patient care and the pharmacist's role on the health care team.


2021 ◽  
Vol 13 (2) ◽  
pp. 22
Author(s):  
Xavier Boulet ◽  
Mahdi Zargayouna ◽  
Gérard Scemama ◽  
Fabien Leurent

Modeling and simulation play an important role in transportation networks analysis. In the literature, authors have proposed many traffic and mobility simulations, with different features and corresponding to different contexts and objectives. They notably consider different scales of simulations. The scales refer to the represented entities, as well as to the space and the time representation of the transportation environment. However, we often need to represent different scales in the same simulation, for instance to represent a neighborhood interacting with a wider region. In this paper, we advocate for the reuse of existing simulations to build a new multi-scale simulation. To do so, we propose a middleware model to couple independent mobility simulations, working at different scales. We consider all the necessary processing and workflow to allow for a coherent orchestration of these simulations. We also propose a prototype implementation of the middleware. The results show that such a middleware is capable of creating a new multi-scale mobility simulation from existing ones, while minimizing the incoherence between them. They also suggest that, to have a maximal benefit from the middleware, existing mobility simulation platforms should allow for an external control of the simulations, allowing for executing a time step several times if necessary.


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