Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging

1991 ◽  
pp. 29-35 ◽  
Author(s):  
Mauro Magnani ◽  
Luigia Rossi ◽  
Marzia Bianchi ◽  
Giordano Serafini ◽  
Vilberto Stocchi
Keyword(s):  
Cell Aging ◽  
Reticulocyte Maturation

Kinetics of cell age-dependent decline of insulin receptors in human red cells

1984 ◽  
Vol 247 (5) ◽  
pp. E667-E674
Author(s):  
G. Baumann ◽  
J. G. MacCart
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Lactate Production ◽  
Insulin Receptors ◽  
Red Cells ◽  
Cell Aging ◽  
Rapid Decline ◽  
Cell Age ◽  
Reticulocyte Maturation ◽  
Kinetics Of

Insulin receptors are present in human erythrocytes and correlate negatively with cellular age. Little is known about the function of these receptors, about the precise kinetics of their decline during cell aging or about their fate after disappearance from the cells. To elucidate some of these questions, we have prepared red blood cell populations of widely varying cellular ages (ranging from the erythroblast stage to senescent mature erythrocytes) by isopycnic centrifugation on isosmolar density gradients. In addition, young red cells were cultured for 4 days in vitro to permit observation of short-term changes. In mature erythrocytes, insulin receptors decreased as an exponential function of cell age with an estimated half time of 40 days. A more rapid decline of insulin receptors occurred coincident with reticulocyte maturation. Loss of receptors from cultured cells was accompanied by appearance of a soluble insulin receptor in the medium. The effect of insulin on glucose utilization in erythroblast and reticulocyte preparations was negligible, as assessed by CO2 and lactate production. We conclude that 1) insulin receptors are progressively lost from the red blood cell after the erythroblast stage; 2) receptor loss is particularly rapid during reticulocyte maturation; 3) shedding of receptors into the extracellular environment is one reason for their depletion from cells; and 4) in basophilic erythroblasts and reticulocytes, insulin exhibits little metabolic action despite the relatively high receptor complement present in these cells.

Adenine and pyridine nucleotides during rabbit reticulocyte maturation and cell aging

1987 ◽  
Vol 39 (1) ◽  
pp. 29-44 ◽  
Author(s):  
Vilberto Stocchi ◽  
Nada Kolb ◽  
Luigi Cucchiarini ◽  
Maria Segni ◽  
Mauro Magnani ◽  
...  
Keyword(s):  
Cell Aging ◽  
Pyridine Nucleotides ◽  
Reticulocyte Maturation

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors

2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2116-P
Author(s):  
JEEYEON CHA ◽  
EMILY M. WALKER ◽  
XIN TONG ◽  
MIN GUO ◽  
JIN HUA LIU ◽  
...  
Keyword(s):  
Beta Cell ◽  
Missense Mutation ◽  
Cell Aging ◽  
Islet Beta Cell

scholarly journals Extracellular Vesicles of Mesenchymal Stem Cells: Therapeutic Properties Discovered with Extraordinary SuccessOK

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 667
Author(s):  
Gabriella Racchetti ◽  
Jacopo Meldolesi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Responses ◽  
Extracellular Vesicles ◽  
Immune Regulation ◽  
Great Increase ◽  
The Body ◽  
Cell Aging ◽  
Therapeutic Effects ◽  
Therapeutic Properties

Mesenchymal stem cells (MSCs), the cells distributed in the stromas of the body, are known for various properties including replication, the potential of various differentiations, the immune-related processes including inflammation. About two decades ago, these cells were shown to play relevant roles in the therapy of numerous diseases, dependent on their immune regulation and their release of cytokines and growth factors, with ensuing activation of favorable enzymes and processes. Such discovery induced great increase of their investigation. Soon thereafter, however, it became clear that therapeutic actions of MSCs are risky, accompanied by serious drawbacks and defects. MSC therapy has been therefore reduced to a few diseases, replaced for the others by their extracellular vesicles, the MSC-EVs. The latter vesicles recapitulate most therapeutic actions of MSCs, with equal or even better efficacies and without the serious drawbacks of the parent cells. In addition, MSC-EVs are characterized by many advantages, among which are their heterogeneities dependent on the stromas of origin, the alleviation of cell aging, the regulation of immune responses and inflammation. Here we illustrate the MSC-EV therapeutic effects, largely mediated by specific miRNAs, covering various diseases and pathological processes occurring in the bones, heart and vessels, kidney, and brain. MSC-EVs operate also on the development of cancers and on COVID-19, where they alleviate the organ lesions induced by the virus. Therapy by MSC-EVs can be improved by combination of their innate potential to engineering processes inducing precise targeting and transfer of drugs. The unique properties of MSC-EVs explain their intense studies, carried out with extraordinary success. Although not yet developed to clinical practice, the perspectives for proximal future are encouraging.

Hallmarks of T cell aging

2021 ◽  
Author(s):  
Maria Mittelbrunn ◽  
Guido Kroemer
Keyword(s):  
T Cell ◽  
Cell Aging

Glutathione-linked enzyme activities in red cell aging

1986 ◽  
Vol 159 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Hitoshi Imanishi ◽  
Tetsuro Nakai ◽  
Tatsuo Abe ◽  
Tatsuro Takino
Keyword(s):  
Enzyme Activities ◽  
Cell Aging ◽  
Red Cell
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