The visual system is human know the important sensory system of the external world, due to a variety of diseases or other injury, leading to the increasing number of blind visual loss, the visual cortex prosthesis research is expected to provide a way of blind sight. Based on unique information transfer mechanism of the biological visual system, the visual cortex prosthesis framework is designed, and for the core module of the prosthesis, it is proposed based on the simple cell selective characteristics of visual system, sparse response characteristics, synchronous oscillations and other image information coding strategy of the mechanism. The algorithm is used for the actual image analysis, to compared with conventional sparse representation method, under the prerequisite of assuring image quality, the strategy can be used as little as possible neuronal to characterize the important information of natural images, thus effectively reducing the prosthesis embedded cortex stimulation electrode quantity, to achieve better information transfer effect.