Photodynamic Therapy as a Novel Antimicrobial Strategy Against Biofilm-Based Nosocomial Infections: Study Protocols

2014 ◽  
pp. 287-298 ◽  
Author(s):  
Francesco Giuliani
Keyword(s):  
Photodynamic Therapy ◽  
Nosocomial Infections ◽  
Study Protocols

scholarly journals Antimicrobial photodynamic therapy on Staphylococcus aureus and Escherichia coli using malachite green encapsulated mesoporous silica nanoparticles: an in vitro study

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7454 ◽  
Author(s):  
Parasuraman Paramanantham ◽  
Busi Siddhardha ◽  
Sruthil Lal SB ◽  
Alok Sharan ◽  
Abdullah A. Alyousef ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Malachite Green ◽  
Nosocomial Infections ◽  
Mesoporous Silica Nanoparticles ◽  
Healthcare Sector ◽  
E Coli

Background Rise in the number of healthcare associated or hospital acquired infections is a major problem affecting the global healthcare sector. We evaluated superior antibacterial and antibiofilm photodynamic therapy (aPDT) using malachite green encapsulated mesoporous silica nanoparticles (MG-MSN) against Staphylococcus aureus and Escherichia coli, which are known to be major causative agents of nosocomial infections. Methods Malachite green (MG) was encapsulated on mesoporous silica nanoparticles (MSN). Fourier-transform infrared spectroscopy, Transmission electron microscopy, and spectroscopic analysis were performed to characterize the MG-MSN. The antimicrobial efficacies of MSN, MG, and MG-MSN were investigated and the results were recorded. Results MG-MSN was effective against both the tested bacteria. S. aureus was more phototoxic to MG-MSN compared to E. coli. The antibiofilm efficacy of MG-MSN on E. coli and S. aureus was also studied. Biofilm inhibition was 65.68 ± 2.62% in E. coli and 79.66 ± 3.82% in S. aureus. Cell viability assay, exopolysaccharides quantification, and confocal laser scanning microscopy studies also revealed the enhanced antibiofilm activity of MG-MSN when used as a potential photosensitizer for aPDT. This study can be extended to eradicate these strains from localized superficial infections and medical appliances, preventing nosocomial infections.

scholarly journals Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 20 (14) ◽  
pp. 3585 ◽  
Author(s):  
Analú Barros de Oliveira ◽  
Túlio Morandin Ferrisse ◽  
Raquel Souza Marques ◽  
Sarah Raquel de Annunzio ◽  
Fernanda Lourenção Brighenti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Dental Caries ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Research Question ◽  
Microbial Reduction ◽  
Cochrane Library ◽  
Study Protocols

The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

2020 ◽  
Vol 49 (33) ◽  
pp. 11583-11590 ◽  
Author(s):  
Zheng-Yin Pan ◽  
Dai-Hong Cai ◽  
Liang He
Keyword(s):  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Lysosomal Dysfunction ◽  
Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

Involvement of CFTR in photodynamic therapy-mediated apoptosis

2010 ◽  
Vol 34 (8) ◽  
pp. S44-S44
Author(s):  
Juan Juan Chen ◽  
Xiao Hua Jiang ◽  
Hsiao Chang Chan
Keyword(s):  
Photodynamic Therapy

Nosocomial infections related to fibreoptic intubation

Anaesthesia ◽  
2000 ◽  
Vol 55 (8) ◽  
pp. 816-817 ◽  
Author(s):  
W. R. Garrett ◽  
M. B. Hough
Keyword(s):  
Nosocomial Infections ◽  
Fibreoptic Intubation

Apoptosis is induced by caspase activation and cytochrome c release in photodynamic therapy (PDT) of human hepatoteilular carcinoma cells

2001 ◽  
Vol 120 (5) ◽  
pp. A363-A363
Author(s):  
A OKUMURA ◽  
M HAMBLIN ◽  
T HASAN ◽  
T ISHIKAWA ◽  
S KAKUMU ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cytochrome C ◽  
Carcinoma Cells ◽  
Caspase Activation ◽  
Cytochrome C Release
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