scholarly journals A Novel Microfluidic Device for Isolation of Circulating Tumor Cells from Pancreatic Cancer Blood Samples

Author(s):  
Jose I. Varillas ◽  
Kangfu Chen ◽  
Jinling Zhang ◽  
Thomas J. George ◽  
Z. Hugh Fan
PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147400 ◽  
Author(s):  
Priya Gogoi ◽  
Saedeh Sepehri ◽  
Yi Zhou ◽  
Michael A. Gorin ◽  
Carmela Paolillo ◽  
...  

2019 ◽  
Vol Volume 11 ◽  
pp. 7405-7425 ◽  
Author(s):  
Lianyuan Tao ◽  
Li Su ◽  
Chunhui Yuan ◽  
Zhaolai Ma ◽  
Lingfu Zhang ◽  
...  

Lab on a Chip ◽  
2019 ◽  
Vol 19 (20) ◽  
pp. 3427-3437 ◽  
Author(s):  
Chia-Heng Chu ◽  
Ruxiu Liu ◽  
Tevhide Ozkaya-Ahmadov ◽  
Mert Boya ◽  
Brandi E. Swain ◽  
...  

A monolithic 3D-printed microfluidic device integrated with stacked layers of functionalized leukodepletion channels and microfiltration for the negative enrichment of circulating tumor cells directly from clinically relevant volumes of whole blood.


Small ◽  
2019 ◽  
Vol 15 (14) ◽  
pp. 1970075
Author(s):  
Mahlet Fasil Abate ◽  
Shasha Jia ◽  
Metages Gashaw Ahmed ◽  
Xingrui Li ◽  
Li Lin ◽  
...  

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1659 ◽  
Author(s):  
Verena Martini ◽  
Sylvia Timme-Bronsert ◽  
Stefan Fichtner-Feigl ◽  
Jens Hoeppner ◽  
Birte Kulemann

Pancreatic cancer is the fourth leading cause of cancer-related death in the USA and Europe; early symptoms and screenings are lacking, and it is usually diagnosed late with a poor prognosis. Circulating tumor cells (CTCs) have been promising new biomarkers in solid tumors. In the last twenty years (1999–2019), 140 articles have contained the key words “Circulating tumor cells, pancreatic cancer, prognosis and diagnosis.” Articles were evaluated for the use of CTCs as prognostic markers and their correlation to survival in pancreatic ductal adenocarcinoma (PDAC). In the final selected 17 articles, the CTC detection rate varied greatly between different enrichment methodologies and ranged from 11% to 92%; the majority of studies used the antigen-dependent CellSearch© system for CTC detection. Fifteen of the reviewed studies showed a correlation between CTC presence and a worse overall survival. The heterogeneity of CTC-detection methods and the lack of uniform results hinder a comparison of the evaluated studies. However, CTCs can be detected in pancreatic cancer and harbor a hope to serve as an early detection tool. Larger studies are needed to corroborate CTCs as valid biomarkers in pancreatic cancer.


2017 ◽  
Vol 66 (1) ◽  
pp. 172-178 ◽  
Author(s):  
Mao Lin ◽  
Mohammed Alnaggar ◽  
Shu-Zhen Liang ◽  
Jian Shi ◽  
Li-Zhi Niu ◽  
...  

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