Isolation and Analysis of Human Monocytes and Adipose Tissue Macrophages

2019 ◽  
pp. 33-48 ◽  
Author(s):  
Jean-Baptiste Julla ◽  
Raphaelle Ballaire ◽  
Tina Ejlalmanesh ◽  
Jean-François Gautier ◽  
Nicolas Venteclef ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Human Monocytes ◽  
Adipose Tissue Macrophages

scholarly journals Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yawei Wang ◽  
Binlin Tang ◽  
Lei Long ◽  
Peng Luo ◽  
Wei Xiang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Oxidative Phosphorylation ◽  
Near Infrared ◽  
Mitochondrial Metabolism ◽  
Diet Induced Obesity ◽  
Adipose Tissue Macrophages ◽  
Inflammatory Activation ◽  
Treatment Of Obesity ◽  
Pharmaceutical Agents

AbstractPro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number of studies have demonstrated the crucial role of mitochondrial metabolism in macrophage activation. However, there is a lack of pharmaceutical agents to target the mitochondrial metabolism of ATMs for the treatment of obesity-related diseases. Here, we characterize a near-infrared fluorophore (IR-61) that preferentially accumulates in the mitochondria of ATMs and has a therapeutic effect on diet-induced obesity as well as obesity-associated insulin resistance and fatty liver. IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway. Taken together, our findings indicate that specific enhancement of ATMs oxidative phosphorylation improves chronic inflammation and obesity-related disorders. IR-61 might be an anti-inflammatory agent useful for the treatment of obesity-related diseases by targeting the mitochondria of ATMs.

Leptin in the regulation of the immunometabolism of adipose tissue‐macrophages

2019 ◽  
Vol 106 (3) ◽  
pp. 703-716 ◽  
Author(s):  
Lauar Monteiro ◽  
Jéssica Aparecida da Silva Pereira ◽  
Lohanna Palhinha ◽  
Pedro Manoel M. Moraes‐Vieira
Keyword(s):  
Adipose Tissue ◽  
Adipose Tissue Macrophages

Folate receptor expression on murine and human adipose tissue macrophages

2015 ◽  
Vol 64 (9) ◽  
pp. 697-706 ◽  
Author(s):  
Michael J. Hansen ◽  
N. Achini Bandara ◽  
Philip S. Low
Keyword(s):  
Adipose Tissue ◽  
Folate Receptor ◽  
Human Adipose Tissue ◽  
Receptor Expression ◽  
Adipose Tissue Macrophages

A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity

2021 ◽  
Vol 37 (1) ◽  
pp. 549-573
Author(s):  
Conan J.O. O'Brien ◽  
Emma R. Haberman ◽  
Ana I. Domingos
Keyword(s):  
Adipose Tissue ◽  
Energy Homeostasis ◽  
Current Knowledge ◽  
Neural Circuitry ◽  
Leptin Resistance ◽  
Direct Role ◽  
Adipose Tissues ◽  
Adipose Tissue Macrophages ◽  
Prevalence Of Obesity ◽  
Established Role

The prevalence of obesity is on the rise. What was once considered a simple disease of energy imbalance is now recognized as a complex condition perpetuated by neuro- and immunopathologies. In this review, we summarize the current knowledge of the neuroimmunoendocrine mechanisms underlying obesity. We examine the pleiotropic effects of leptin action in addition to its established role in the modulation of appetite, and we discuss the neural circuitry mediating leptin action and how this is altered with obesity, both centrally (leptin resistance) and in adipose tissues (sympathetic neuropathy). Finally, we dissect the numerous causal and consequential roles of adipose tissue macrophages in obesity and highlight recent key studies demonstrating their direct role in organismal energy homeostasis.

scholarly journals INFLAMMATION, BUT NOT RECRUITMENT, OF ADIPOSE TISSUE MACROPHAGES REQUIRES SIGNALING THROUGH MAC-1 IN DIET-INDUCED OBESITY (DIO)

2015 ◽  
Vol 65 (10) ◽  
pp. A2085
Author(s):  
Dennis Wolf ◽  
Nathaly Anto Michel ◽  
Bukosza Nora ◽  
David Engel ◽  
Marjorie Poggi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Diet Induced Obesity ◽  
Adipose Tissue Macrophages
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