Catheters for Chronic Administration of Drugs into Brain Tissue

2008 ◽  
pp. 109-117 ◽  
Author(s):  
Michael Guarnieri ◽  
Benjamin S. Carson ◽  
George I. Jallo
Keyword(s):  
Brain Tissue ◽  
Chronic Administration

scholarly journals Author Correction: Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ahmed Mohsen Hamdan ◽  
Mohammed M. Al-Gayyar ◽  
Mohamed E. E. Shams ◽  
Udai Salamh Alshaman ◽  
Kousalya Prabahar ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Inflammatory Mediators ◽  
Chronic Administration ◽  
Food Preservatives

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

EFFECTS OF CHRONIC ADMINISTRATION OF METH-AMPHETAMINE IN ENZYMIC PATTERNS IN BRAIN TISSUE

1959 ◽  
Vol 4 (2) ◽  
pp. 161-169 ◽  
Author(s):  
H. Utena ◽  
T. Ezoe ◽  
N. Kato ◽  
H. Hada
Keyword(s):  
Brain Tissue ◽  
Chronic Administration

scholarly journals Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ahmed Mohsen Hamdan ◽  
Mohammed M. Al-Gayyar ◽  
Mohamed E. E. Shams ◽  
Udai Salamh Alshaman ◽  
Kousalya Prabahar ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Inflammatory Mediators ◽  
Chronic Administration ◽  
Food Preservatives

scholarly journals NEUROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF SARGASSUM WIGHTII ON HALOPERIDOL INDUCED CATALEPSY AND TARDIVE DYSKINESIA IN ALBINO RATS

2020 ◽  
pp. 1-6
Author(s):  
S. ROUT ◽  
B. RATH ◽  
S. K. BHATTAMISRA ◽  
A. KUMAR ◽  
S. RATH
Keyword(s):  
Tardive Dyskinesia ◽  
Brain Tissue ◽  
Methanolic Extract ◽  
Neuroprotective Effect ◽  
Chronic Administration ◽  
Albino Rats ◽  
Sargassum Wightii ◽  
Stress Markers ◽  
Brain Oxidative Stress ◽  
Wistar Albino Rats

Objective: The present study was designed to evaluate the neuroprotective effect of methanolic extract of Sargassum wightii on haloperidol-induced catalepsy and tardive dyskinesia in Wistar albino rats. Methods: In this study, thirty Wistar albino rats were randomly divided into six groups. Gr-I served as control. Haloperidol (1 mg/kg intraperitoneally) was administered to rats of Gr-II to Gr-V for twenty-one consecutive days to induce catalepsy and tardive dyskinesia. Animals of Gr-II to Gr-V were orally administered with vehicle, levodopa carbidopa combination (30 mg/kg), Sargassum extract 200 and 400 mg/kg respectively. All the drugs and vehicles were given orally one hour before haloperidol injection for twenty one consecutive days. The cataleptic scores were recorded using standard bar test. Tardive dyskinesia was assessed in terms of vacuous chewing movement (VCM) and tongue protrusion (TP) scores. After behavioural testing, all animals were sacrificed on twenty-second day and various biochemical parameters like MDA, SOD and GSH were estimated in brain tissue. Results: Chronic administration of haloperidol significantly increased cataleptic scores, VCM and TP scores. (p<0.001) Sargassum wightii extract (400 mg/kg) significantly inhibited haloperidol-induced catalepsy, VCM and TP (p<0.001) Haloperidol increased MDA and decreased SOD and GSH in brain tissue to a highly significant extent (p<0.001) Sargassum extract at 400 mg/kg also significantly reversed the haloperidol-induced alteration in brain oxidative stress markers. Conclusion: Sargassum wightii inhibits haloperidol-induced catalepsy and tardive dyskinesia. Thus it may be used as a unique therapeutic adjunct for the prevention of neuroleptic-induced extrapyramidal symptoms, however, it has to be explored more.

scholarly journals Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

2013 ◽  
Vol 71 (5) ◽  
pp. 313-319 ◽  
Author(s):  
Fatimeh Khodabandehloo ◽  
Mahmoud Hosseini ◽  
Ziba Rajaei ◽  
Mohammad Soukhtanloo ◽  
Esmaeil Farrokhi ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Brain Tissue ◽  
Deleterious Effect ◽  
Escape Latency ◽  
Chronic Administration ◽  
Ovariectomized Rats ◽  
Estradiol Valerate ◽  
High Dose ◽  
Antioxidative Effects ◽  
The Brain

In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p≪0.01 and p≪0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q1 compared to Sham and OVX groups (p≪0.05 and p≪0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p≪0.05 and p≪0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.

scholarly journals Effect of chronic administration of haloperidol and risperidone on the number of dopamine receptors in rat brain tissue

2019 ◽  
Vol 14 (4) ◽  
Author(s):  
Mariya Baturina ◽  
Eduard Beyer ◽  
Alexey Popov ◽  
Vladimir Baturin ◽  
Vladimir Baturin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Dopamine Receptors ◽  
Brain Tissue ◽  
Chronic Administration ◽  
Rat Brain Tissue

Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans

1993 ◽  
Vol 74 (6) ◽  
pp. 2724-2728 ◽  
Author(s):  
M. Nishimura ◽  
A. Yoshioka ◽  
M. Yamamoto ◽  
Y. Akiyama ◽  
K. Miyamoto ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Tissue Oxygenation ◽  
Jugular Vein ◽  
Chronic Administration ◽  
Brain Tissue Oxygenation ◽  
Adenosine Receptor Antagonist ◽  
Wide Range ◽  
Before And After ◽  
Arterial Po2 ◽  
Gas Pressures

Although theophylline, an adenosine receptor antagonist, is known to reduce cerebral blood flow, little clinical attention has been paid to this adverse effect. This study was designed to examine the effect of theophylline on brain tissue oxygenation for a wide range of arterial PO2 in healthy volunteers. Partial gas pressures and O2 saturation in an artery (SaO2) and the internal jugular vein (SjO2) were simultaneously measured while subjects (n = 6) were breathing room air and then exposed to two levels of isocapnic hypoxia (arterial PO2 = 60 and 45 Torr) before and after infusion of theophylline (6 mg/kg of aminophylline). For the same levels of arterial oxygenation, jugular vein PO2 markedly dropped, by 3–5 Torr, after theophylline infusion, as did SjO2, by as much as 6–10%, under the arterial PCO2, which was slightly lower by 1–2 Torr in the theophylline study. By use of the linear regression lines obtained from the relationship between SaO2 and SjO2 in each study, it was calculated that the SjO2 with theophylline, while SaO2 was 95, 90, and 80%, was comparable to that without theophylline when SaO2 was 81, 78, and 73%, respectively. On the basis of the assumption that partial gas pressures and SjO2 reflect brain tissue oxygenation, these data suggest that the effect of theophylline on brain tissue oxygenation should not be ignored in some clinical settings. The effects of chronic administration remain to be studied.

scholarly journals EFFECT OF CHRONIC ADMINISTRATION OF BARBITAFSODIUM ON CAFCIUM CONTENT IN RAT BRAIN TISSUE

1979 ◽  
Vol 29 (2) ◽  
pp. 316-318
Author(s):  
Heitaroh IWATA ◽  
Sadaaki MAEDA ◽  
Yoshihisa HIRATA ◽  
Toshio MATSU DA
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Chronic Administration ◽  
Rat Brain Tissue
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